{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:33:54Z","timestamp":1787502834196,"version":"build-2736575974"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T00:00:00Z","timestamp":1597363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We investigated in a longitudinal multicenter cohort study functional cortical connectivity changes along the course of frontotemporal dementia (FTD) and Alzheimer\u2019s disease (AD) from the prodromal stage of the diseases.<\/jats:p>\n                  <jats:p>Electroencephalography (EEG) was recorded in 18 FTD and 18 AD patients at the prodromal stage of dementia, at dementia onset, and 3\u00a0years after dementia onset. Twenty healthy controls (HC) underwent EEG recordings at the same time interval as the patients.<\/jats:p>\n                  <jats:p>Mutual information (MI) analysis measured the strength of functional network connectivity.<\/jats:p>\n                  <jats:p>FTD and AD patients showed greater MI at the prodromal stage of dementia (FTD vs. HC P\u2009=\u20092\u2009\u00d7\u200910\u22128; AD vs. HC P\u2009=\u20094\u2009\u00d7\u200910\u20133). Local connectivity was higher in left and right frontal areas of FTD (P\u2009=\u20097\u2009\u00d7\u200910\u22125 and 0.03) and in left and right posterior areas in AD (P\u2009=\u20093\u2009\u00d7\u200910\u22125 and 5\u2009\u00d7\u200910\u22125) versus HC.<\/jats:p>\n                  <jats:p>We showed cortical hyperconnectivity at the prodromal stage of dementia in areas involved in the specific pathological process of FTD (frontal regions) and AD (posterior regions). Hyperconnectivity disappeared during follow-up, thus suggesting that it is an early electrophysiological feature of dementia, potentially useful to identify prodromal FTD and AD.<\/jats:p>","DOI":"10.1093\/cercor\/bhaa209","type":"journal-article","created":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T15:12:05Z","timestamp":1594912325000},"page":"97-105","source":"Crossref","is-referenced-by-count":41,"title":["Hyperconnectivity in Dementia Is Early and Focal and Wanes with Progression"],"prefix":"10.1093","volume":"31","author":[{"given":"Laura","family":"Bonanni","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Imaging and Clinical Sciences, University G. d\u2019Annunzio of Chieti-Pescara, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Moretti","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Alzheimer Unit, 25125 Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Benussi","sequence":"additional","affiliation":[{"name":"Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, 25040 Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Ferri","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Imaging and Clinical Sciences, University G. d\u2019Annunzio of Chieti-Pescara, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirella","family":"Russo","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Imaging and Clinical Sciences, University G. d\u2019Annunzio of Chieti-Pescara, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Carrarini","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Imaging and Clinical Sciences, University G. d\u2019Annunzio of Chieti-Pescara, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filomena","family":"Barbone","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Imaging and Clinical Sciences, University G. d\u2019Annunzio of Chieti-Pescara, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Arnaldi","sequence":"additional","affiliation":[{"name":"Dipartimento di Neuroscienze (DINOGMI), University of Genova, 16132 Genoa, Italy"},{"name":"U.O. Clinica Neurologica, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola Walter","family":"Falasca","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Imaging and Clinical Sciences, University G. d\u2019Annunzio of Chieti-Pescara, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Koch","sequence":"additional","affiliation":[{"name":"Non Invasive Brain Stimulation Unit\/Department of Behavioral and Clinical Neurology, Santa Lucia Foundation IRCCS, 00179 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annachiara","family":"Cagnin","sequence":"additional","affiliation":[{"name":"Stroke Unit, Department of Neuroscience, Tor Vergata Policlinic, 00184 Rome, Italy"},{"name":"Department of Neurosciences, University of Padua, 35128 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavio","family":"Nobili","sequence":"additional","affiliation":[{"name":"Dipartimento di Neuroscienze (DINOGMI), University of Genova, 16132 Genoa, Italy"},{"name":"U.O. Clinica Neurologica, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Babiloni","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology \u201cV. Erspamer\u201d, Sapienza University of Rome, 00185 Rome, Italy"},{"name":"Hospital San Raffaele Cassino (FR), 03043 Cassino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Borroni","sequence":"additional","affiliation":[{"name":"Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, 25040 Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Padovani","sequence":"additional","affiliation":[{"name":"Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, 25040 Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Onofrj","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Imaging and Clinical Sciences, University G. d\u2019Annunzio of Chieti-Pescara, 66100 Chieti, 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