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Here, we investigated the causal role of mPPC (putatively, human area V6A\u2013hV6A) in encoding depth and direction of reaching. Specifically, we applied single-pulse transcranial magnetic stimulation (TMS) over the left hV6A at different time points while 15 participants were planning immediate, visually guided reaching by using different eye-hand configurations. We found that TMS delivered over hV6A 200\u00a0ms after the Go signal affected the encoding of the depth of reaching by decreasing the accuracy of movements toward targets located farther with respect to the gazed position, but only when they were also far from the body. The effectiveness of both retinotopic (farther with respect to the gaze) and spatial position (far from the body) is in agreement with the presence in the monkey V6A of neurons employing either retinotopic, spatial, or mixed reference frames during reach plan. This work provides the first causal evidence of the critical role of hV6A in the planning of visually guided reaching movements in depth.<\/jats:p>","DOI":"10.1093\/cercor\/bhaa224","type":"journal-article","created":{"date-parts":[[2020,7,25]],"date-time":"2020-07-25T19:08:52Z","timestamp":1595704132000},"page":"267-280","source":"Crossref","is-referenced-by-count":20,"title":["Transcranial Magnetic Stimulation Over the Human Medial Posterior Parietal Cortex Disrupts Depth Encoding During Reach Planning"],"prefix":"10.1093","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5059-1441","authenticated-orcid":false,"given":"Rossella","family":"Breveglieri","sequence":"first","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences, University of Bologna, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3032-9571","authenticated-orcid":false,"given":"Annalisa","family":"Bosco","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences, University of Bologna, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4959-6442","authenticated-orcid":false,"given":"Sara","family":"Borgomaneri","sequence":"additional","affiliation":[{"name":"Center for studies and research in Cognitive Neuroscience, University of Bologna, 47521 Cesena, Italy"},{"name":"IRCCS, Santa Lucia Foundation, 00179 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6616-2454","authenticated-orcid":false,"given":"Alessia","family":"Tessari","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Bologna, 40127 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8927-3408","authenticated-orcid":false,"given":"Claudio","family":"Galletti","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences, University of Bologna, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1139-9996","authenticated-orcid":false,"given":"Alessio","family":"Avenanti","sequence":"additional","affiliation":[{"name":"Center for studies and research in Cognitive Neuroscience, University of Bologna, 47521 Cesena, Italy"},{"name":"Center for research in Neuropsychology and Cognitive Neurosciences, Catholic University of Maule, 3460000 Talca, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0079-3755","authenticated-orcid":false,"given":"Patrizia","family":"Fattori","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences, University of Bologna, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,9,30]]},"reference":[{"key":"2020121009243376000_ref1","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/0168-5597(89)90036-1","article-title":"Suppression of visual perception by magnetic coil stimulation of human occipital cortex","volume":"74","author":"Amassian","year":"1989","journal-title":"Electroencephalogr Clin Neurophysiol Evoked Potentials"},{"key":"2020121009243376000_ref2","doi-asserted-by":"crossref","first-page":"40937","DOI":"10.1038\/srep40937","article-title":"Visual area V5\/hMT+ contributes to perception of tactile motion 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