{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:41:05Z","timestamp":1788543665492,"version":"build-2803163510"},"reference-count":95,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T00:00:00Z","timestamp":1598572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Florida State University Research Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Perinatal nicotine exposure (PNE) produces frontal cortical hypo-dopaminergic state and attention and working memory deficits consistent with neurodevelopmental disorders such as attention deficit hyperactivity disorder (ADHD). Methylphenidate alleviates ADHD symptoms by increasing extracellular dopamine and noradrenaline. Kappa opioid receptor (KOR) antagonism may be another mechanism to achieve the same results because KOR activation inhibits frontal cortical dopamine release. We administered the selective KOR antagonist norbinaltorphimine (norBNI) (20\u00a0mg\/kg; intraperitoneal) or methylphenidate (0.75\u00a0mg\/kg; intraperitoneal) to PNE mouse model and examined frontal cortical monoamine release, attention, and working memory. Both compounds increased dopamine and noradrenaline release but neither influenced serotonin release. Both compounds improved object-based attention and working memory in the PNE group, with norBNI\u2019s effects evident at 2.5\u00a0h and 5.5\u00a0h but absent at 24\u00a0h. Methylphenidate\u2019s effects were evident at 0.5\u00a0h but not at 2.5\u00a0h. norBNI\u2019s effects temporally coincided with frontal cortical c-Jun N-terminal kinase phosphorylation. norBNI did not alter tissue dopamine content in the nucleus accumbens, offering preliminary support for lack of reinforcement.<\/jats:p>","DOI":"10.1093\/cercor\/bhaa238","type":"journal-article","created":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T11:25:40Z","timestamp":1596540340000},"page":"483-496","source":"Crossref","is-referenced-by-count":18,"title":["Frontal Cortical Monoamine Release, Attention, and Working Memory in a Perinatal Nicotine Exposure Mouse Model Following Kappa Opioid Receptor Antagonism"],"prefix":"10.1093","volume":"31","author":[{"given":"Lin","family":"Zhang","sequence":"first","affiliation":[{"name":"Biomedical Sciences, Florida State University College of Medicine, Tallahassee, FL 32306, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deirdre M","family":"McCarthy","sequence":"additional","affiliation":[{"name":"Biomedical Sciences, Florida State University College of Medicine, Tallahassee, FL 32306, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen L","family":"Eskow Jaunarajs","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Alabama at Birmingham, Birmingham, AL 35294, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Biederman","sequence":"additional","affiliation":[{"name":"Pediatric Psychopharmacology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J","family":"Spencer","sequence":"additional","affiliation":[{"name":"Pediatric Psychopharmacology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4236-9415","authenticated-orcid":false,"given":"Pradeep G","family":"Bhide","sequence":"additional","affiliation":[{"name":"Biomedical Sciences, Florida State University College of Medicine, Tallahassee, FL 32306, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,8,28]]},"reference":[{"key":"2020121009235956000_ref1","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/npp.2017.133","article-title":"Kappa-opioid receptor activation in dopamine neurons disrupts Behavioral inhibition","volume":"43","author":"Abraham","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"2020121009235956000_ref2","doi-asserted-by":"crossref","first-page":"8031","DOI":"10.1523\/JNEUROSCI.0653-18.2018","article-title":"Estrogen regulation of GRK2 inactivates kappa opioid receptor Signaling mediating analgesia, but not 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