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However, we know little about either the onset of this phenomenon or its early effects on functional brain networks. We studied functional connectivity (FC) on 127 participants (92 middle-age relatives of AD patients and 35 age-matched nonrelatives) using magnetoencephalography. FC was estimated in the alpha band in areas known both for early amyloid accumulation and disrupted FC in MCI converters to AD. We found a frontoparietal network (anterior cingulate cortex, dorsal frontal, and precuneus) where relatives of AD patients showed hypersynchronization in high alpha (not modulated by APOE-\u03b54 genotype) in comparison to age-matched nonrelatives. These results represent the first evidence of neurophysiological events causing early network disruption in humans, opening a new perspective for intervention on the excitation\/inhibition unbalance.<\/jats:p>","DOI":"10.1093\/cercor\/bhaa286","type":"journal-article","created":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T11:09:30Z","timestamp":1599476970000},"page":"1201-1210","source":"Crossref","is-referenced-by-count":46,"title":["Functional Connectivity Hypersynchronization in Relatives of Alzheimer\u2019s Disease Patients: An Early E\/I Balance Dysfunction?"],"prefix":"10.1093","volume":"31","author":[{"given":"F","family":"Ram\u00edrez-Tora\u00f1o","sequence":"first","affiliation":[{"name":"Laboratory of Cognitive and Computational Neuroscience, Center for Biomedical Technology, Technical University of Madrid, Madrid, Comunidad de Madrid 28223, Spain"},{"name":"Department of Experimental Psychology, Universidad Complutense de Madrid, Madrid, Comunidad de Madrid 28223, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Bru\u00f1a","sequence":"additional","affiliation":[{"name":"Laboratory of Cognitive and Computational Neuroscience, Center for Biomedical Technology, Technical University of Madrid, Madrid, Comunidad de Madrid 28223, Spain"},{"name":"Department of Experimental Psychology, Universidad Complutense de Madrid, Madrid, Comunidad de Madrid 28223, Spain"},{"name":"Networking Research Center on Bioengineering, Biomaterials, and Nanomedicine (CIBER-BBN), Madrid, Comunidad de Madrid 28029, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"de Frutos-Lucas","sequence":"additional","affiliation":[{"name":"Laboratory of Cognitive and Computational Neuroscience, Center for Biomedical Technology, Technical University of Madrid, Madrid, Comunidad de Madrid 28223, Spain"},{"name":"Biological and Health Psychology Department, Universidad Autonoma de Madrid, Madrid, Comunidad de Madrid 28049, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I C","family":"Rodr\u00edguez-Rojo","sequence":"additional","affiliation":[{"name":"Laboratory of Cognitive and Computational Neuroscience, Center for Biomedical Technology, Technical University of Madrid, Madrid, Comunidad de Madrid 28223, Spain"},{"name":"Facultad de Psicolog\u00eda, Centro Universitario Villanueva, Madrid, Comunidad de Madrid 28034, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Marcos de Pedro","sequence":"additional","affiliation":[{"name":"Laboratory of Cognitive and Computational Neuroscience, Center for Biomedical Technology, Technical University of Madrid, Madrid, Comunidad de Madrid 28223, Spain"},{"name":"Facultad de Educaci\u00f3n y Salud, Universidad Camilo Jos\u00e9 Cela, Madrid, Comunidad de Madrid 28010, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M L","family":"Delgado-Losada","sequence":"additional","affiliation":[{"name":"Department of Experimental Psychology, Universidad Complutense de Madrid, Madrid, Comunidad de Madrid 28223, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"G\u00f3mez-Ruiz","sequence":"additional","affiliation":[{"name":"Secci\u00f3n Neurorradiolog\u00eda, Servicio de Diagn\u00f3stico por Imagen, Hospital Cl\u00ednico San Carlos, Madrid, Comunidad de Madrid 28040, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Barabash","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Department, Hospital Clinico San Carlos and Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos, Madrid, Comunidad de Madrid 28040, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Diabetes y Enfermedades Metab\u00f3licas Asociadas, Madrid, Comunidad de Madrid 28029, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Marcos","sequence":"additional","affiliation":[{"name":"Neurology Department, Hospital Clinico San Carlos and Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos, Madrid, Comunidad de Madrid 28040, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"L\u00f3pez Higes","sequence":"additional","affiliation":[{"name":"Department of Experimental Psychology, Universidad Complutense de Madrid, Madrid, Comunidad de Madrid 28223, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Maest\u00fa","sequence":"additional","affiliation":[{"name":"Laboratory of Cognitive and Computational Neuroscience, Center for Biomedical Technology, Technical University of Madrid, Madrid, Comunidad de Madrid 28223, Spain"},{"name":"Department of Experimental Psychology, Universidad Complutense de Madrid, Madrid, Comunidad de Madrid 28223, 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