{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T13:06:23Z","timestamp":1784811983707,"version":"3.55.0"},"reference-count":134,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T00:00:00Z","timestamp":1606694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003176","name":"Ministerio de Educaci\u00f3n, Cultura y Deporte","doi-asserted-by":"publisher","award":["FPU14\/02245"],"award-info":[{"award-number":["FPU14\/02245"]}],"id":[{"id":"10.13039\/501100003176","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Union\u2019s Horizon 2020 Research and Innovation Programme","award":["785907"],"award-info":[{"award-number":["785907"]}]},{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["PGC2018-094307-B-I00"],"award-info":[{"award-number":["PGC2018-094307-B-I00"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015496","name":"CIBERNED","doi-asserted-by":"publisher","award":["CB06\/05\/0066"],"award-info":[{"award-number":["CB06\/05\/0066"]}],"id":[{"id":"10.13039\/501100015496","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Centro de Investigaci\u00f3n en Red sobre Enfermedades Neurodegenerativas"},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","award":["JUST-2017-AG-DRUGS-806996-JUSTSO"],"award-info":[{"award-number":["JUST-2017-AG-DRUGS-806996-JUSTSO"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UNED-Banco Santander","award":["2017-VICE-0012"],"award-info":[{"award-number":["2017-VICE-0012"]}]},{"DOI":"10.13039\/501100005367","name":"UNED","doi-asserted-by":"publisher","award":["2014-040-UNED-POST"],"award-info":[{"award-number":["2014-040-UNED-POST"]}],"id":[{"id":"10.13039\/501100005367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016658","name":"Plan Nacional sobre Drogas","doi-asserted-by":"publisher","award":["2016I073"],"award-info":[{"award-number":["2016I073"]}],"id":[{"id":"10.13039\/100016658","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003751","name":"Ministerio de Sanidad, Servicios Sociales e Igualdad","doi-asserted-by":"publisher","award":["RTA-RD16\/0017\/0022"],"award-info":[{"award-number":["RTA-RD16\/0017\/0022"]}],"id":[{"id":"10.13039\/501100003751","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PSI2016-80541-P"],"award-info":[{"award-number":["PSI2016-80541-P"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The hippocampus plays a key role in contextual conditioning and has been proposed as an important component of the cocaine addiction brain circuit. To gain knowledge about cocaine-induced alterations in this circuit, we used focused ion beam milling\/scanning electron microscopy to reveal and quantify the three-dimensional synaptic organization of the neuropil of the stratum radiatum of the rat CA1, under normal circumstances and after cocaine-self administration (SA). Most synapses are asymmetric (excitatory), macular-shaped, and in contact with dendritic spine heads. After cocaine-SA, the size and the complexity of the shape of both asymmetric and symmetric (inhibitory) synapses increased but no changes were observed in the synaptic density. This work constitutes the first detailed report on the 3D synaptic organization in the stratum radiatum of the CA1 field of cocaine-SA rats. Our data contribute to the elucidation of the normal and altered synaptic organization of the hippocampus, which is crucial for better understanding the neurobiological mechanisms underlying cocaine addiction.<\/jats:p>","DOI":"10.1093\/cercor\/bhaa331","type":"journal-article","created":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T15:34:25Z","timestamp":1602776065000},"page":"1927-1952","source":"Crossref","is-referenced-by-count":7,"title":["3D Synaptic Organization of the Rat CA1 and Alterations Induced by Cocaine Self-Administration"],"prefix":"10.1093","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4865-8974","authenticated-orcid":false,"given":"L","family":"Blazquez-Llorca","sequence":"first","affiliation":[{"name":"Departamento de Psicobiolog\u00eda, Facultad de Psicolog\u00eda, Universidad Nacional de Educaci\u00f3n a Distancia (UNED), 28040 Madrid, Spain"},{"name":"Laboratorio Cajal de Circuitos Corticales, Centro de Tecnolog\u00eda Biom\u00e9dica, Universidad Polit\u00e9cnica de Madrid, 28223 Madrid, Spain"},{"name":"Secci\u00f3n Departamental de Anatom\u00eda y Embriolog\u00eda (Veterinaria), Facultad de Veterinaria, Universidad Complutense de Madrid, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Migu\u00e9ns","sequence":"additional","affiliation":[{"name":"Departamento de Psicolog\u00eda B\u00e1sica I, Facultad de Psicolog\u00eda, Universidad Nacional de Educaci\u00f3n a Distancia (UNED), 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Montero-Crespo","sequence":"additional","affiliation":[{"name":"Laboratorio Cajal de Circuitos Corticales, Centro de Tecnolog\u00eda Biom\u00e9dica, Universidad Polit\u00e9cnica de Madrid, 28223 Madrid, Spain"},{"name":"Instituto Cajal, Consejo Superior de Investigaciones Cient\u00edficas, 28002 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Selvas","sequence":"additional","affiliation":[{"name":"Departamento de Psicobiolog\u00eda, Facultad de Psicolog\u00eda, Universidad Nacional de Educaci\u00f3n a Distancia (UNED), 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Gonzalez-Soriano","sequence":"additional","affiliation":[{"name":"Secci\u00f3n Departamental de Anatom\u00eda y Embriolog\u00eda (Veterinaria), Facultad de Veterinaria, Universidad Complutense de Madrid, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Ambrosio","sequence":"additional","affiliation":[{"name":"Departamento de Psicobiolog\u00eda, Facultad de Psicolog\u00eda, Universidad Nacional de Educaci\u00f3n a Distancia (UNED), 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"DeFelipe","sequence":"additional","affiliation":[{"name":"Laboratorio Cajal de Circuitos Corticales, Centro de Tecnolog\u00eda Biom\u00e9dica, Universidad Polit\u00e9cnica de Madrid, 28223 Madrid, Spain"},{"name":"Instituto Cajal, Consejo Superior de Investigaciones Cient\u00edficas, 28002 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,11,30]]},"reference":[{"key":"2021031013283163300_ref1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3389\/fnana.2014.00085","article-title":"Three-dimensional distribution of cortical synapses: a replicated point pattern-based analysis","volume":"8","author":"Anton-Sanchez","year":"2014","journal-title":"Front Neuroanat"},{"key":"2021031013283163300_ref2","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.neuroscience.2006.12.015","article-title":"Non-synaptic dendritic spines in neocortex","volume":"145","author":"Arellano","year":"2007","journal-title":"Neuroscience"},{"key":"2021031013283163300_ref3","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nrn2402","article-title":"Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex","volume":"9","author":"Ascoli","year":"2008","journal-title":"Nat Rev Neurosci"},{"key":"2021031013283163300_ref4","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1002\/hipo.22533","article-title":"Food restriction modifies ultrastructure of hippocampal synapses: food restriction induced synaptic changes in CA1","volume":"26","author":"Babits","year":"2016","journal-title":"Hippocampus"},{"key":"2021031013283163300_ref5","doi-asserted-by":"crossref","DOI":"10.1201\/b19708","volume-title":"Spatial point patterns: methodology and applications with R","author":"Baddeley","year":"2015"},{"key":"2021031013283163300_ref6","doi-asserted-by":"crossref","DOI":"10.18637\/jss.v012.i06","article-title":"Spatstat: an R package for analyzing spatial point patterns","volume":"12","author":"Baddeley","year":"2005","journal-title":"J Stat Softw"},{"key":"2021031013283163300_ref7","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1093\/cercor\/bhj142","article-title":"The effects of morphine self-administration on cortical pyramidal cell structure in addiction-prone Lewis rats","volume":"17","author":"Ballesteros-Y\u00e1\u00f1ez","year":"2007","journal-title":"Cereb Cortex"},{"key":"2021031013283163300_ref8","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1016\/j.neuroscience.2007.03.017","article-title":"Chronic cocaine treatment alters dendritic arborization in the adult motor cortex through a CB1 cannabinoid receptor-dependent mechanism","volume":"146","author":"Ballesteros-Y\u00e1\u00f1ez","year":"2007","journal-title":"Neuroscience"},{"key":"2021031013283163300_ref9","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/cne.902310206","article-title":"A laminar analysis of the number of round-asymmetrical and flat-symmetrical synapses on spines, dendritic trunks, and cell bodies in area 17 of the cat","volume":"231","author":"Beaulieu","year":"1985","journal-title":"J Comp Neurol"},{"key":"2021031013283163300_ref10","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1093\/cercor\/2.4.295","article-title":"Quantitative distribution of GABA-immunopositive and -immunonegative neurons and synapses in the monkey striate cortex (area 17)","volume":"2","author":"Beaulieu","year":"1992","journal-title":"Cereb Cortex"},{"key":"2021031013283163300_ref11","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/j.1460-9568.1990.tb00421.x","article-title":"Targets and quantitative distribution of GABAergic synapses in the visual cortex of the cat","volume":"2","author":"Beaulieu","year":"1990","journal-title":"Eur J Neurosci"},{"key":"2021031013283163300_ref12","first-page":"730","article-title":"Differential structure of hippocampal CA1 pyramidal neurons in the human and mouse","volume":"30","author":"Benavides-Piccione","year":"2020","journal-title":"Cereb Cortex"},{"key":"2021031013283163300_ref13","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1152\/jn.1983.50.5.1197","article-title":"Single-unit analysis of different hippocampal cell types during classical conditioning of rabbit nictitating membrane response","volume":"50","author":"Berger","year":"1983","journal-title":"J Neurophysiol"},{"key":"2021031013283163300_ref14","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.neuron.2017.10.006","article-title":"Transcellular Nanoalignment of synaptic function","volume":"96","author":"Biederer","year":"2017","journal-title":"Neuron"},{"key":"2021031013283163300_ref15","doi-asserted-by":"crossref","first-page":"5840","DOI":"10.1523\/JNEUROSCI.22-14-05840.2002","article-title":"Presynaptic mitochondrial calcium sequestration influences transmission at mammalian central synapses","volume":"22","author":"Billups","year":"2002","journal-title":"J Neurosci"},{"key":"2021031013283163300_ref16","doi-asserted-by":"crossref","first-page":"995","DOI":"10.3233\/JAD-122038","article-title":"FIB\/SEM technology and Alzheimer\u2019s disease: three-dimensional analysis of human cortical synapses","volume":"34","author":"Blazquez-Llorca","year":"2013","journal-title":"J Alzheimers Dis"},{"key":"2021031013283163300_ref17","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/361031a0","article-title":"A synaptic model of memory: long-term potentiation in the hippocampus","volume":"361","author":"Bliss","year":"1993","journal-title":"Nature"},{"key":"2021031013283163300_ref18","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1038\/npp.2017.153","article-title":"Accumbens mechanisms for cued sucrose seeking","volume":"42","author":"Bobadilla","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"2021031013283163300_ref19","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1126\/science.1237059","article-title":"Cocaine disinhibits dopamine neurons by potentiation of GABA transmission in the ventral tegmental area","volume":"341","author":"Bocklisch","year":"2013","journal-title":"Science"},{"key":"2021031013283163300_ref20","doi-asserted-by":"crossref","first-page":"4282","DOI":"10.1093\/cercor\/bhw216","article-title":"Reelin regulates the maturation of dendritic spines, synaptogenesis and glial ensheathment of newborn granule cells","volume":"26","author":"Bosch","year":"2016","journal-title":"Cereb Cortex"},{"key":"2021031013283163300_ref21","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.conb.2011.10.019","article-title":"Nanoscale analysis of structural synaptic plasticity","volume":"22","author":"Bourne","year":"2012","journal-title":"Curr Opin Neurobiol"},{"key":"2021031013283163300_ref22","doi-asserted-by":"crossref","first-page":"E2410","DOI":"10.1073\/pnas.1716189115","article-title":"Long-term potentiation expands information content of hippocampal dentate gyrus synapses","volume":"115","author":"Bromer","year":"2018","journal-title":"Proc Natl Acad Sci USA"},{"key":"2021031013283163300_ref23","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1152\/japplphysiol.00063.2013","article-title":"Skeletal muscle mitochondrial and lipid droplet content assessed with standardized grid sizes for stereology","volume":"115","author":"Broskey","year":"2013","journal-title":"J Appl Physiol"},{"key":"2021031013283163300_ref24","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3389\/fnins.2016.00013","article-title":"Fischer 344 and Lewis rat strains as a model of genetic vulnerability to drug addiction","volume":"10","author":"Cadoni","year":"2016","journal-title":"Front Neurosci"},{"key":"2021031013283163300_ref25","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.pharep.2013.09.002","article-title":"Cocaine-induced glutamate receptor trafficking is abrogated by extinction training in the rat hippocampus","volume":"66","author":"Caffino","year":"2014","journal-title":"Pharmacol Rep"},{"key":"2021031013283163300_ref26","doi-asserted-by":"crossref","first-page":"e0198131","DOI":"10.1371\/journal.pone.0198131","article-title":"The effects of aging on neuropil structure in mouse somatosensory cortex\u2014a 3D electron microscopy analysis of layer 1","volume":"13","author":"Cal\u00ec","year":"2018","journal-title":"PLoS One"},{"key":"2021031013283163300_ref27","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/nrn3258","article-title":"Structural plasticity upon learning: regulation and functions","volume":"13","author":"Caroni","year":"2012","journal-title":"Nat Rev Neurosci"},{"key":"2021031013283163300_ref28","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.neubiorev.2016.03.030","article-title":"A place for the hippocampus in the cocaine addiction circuit: potential roles for adult hippocampal neurogenesis","volume":"66","author":"Castilla-Ortega","year":"2016","journal-title":"Neurosci Biobehav Rev"},{"key":"2021031013283163300_ref29","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.neuron.2008.05.024","article-title":"Cocaine but not natural reward self-administration nor passive cocaine infusion produces persistent LTP in the VTA","volume":"59","author":"Chen","year":"2008","journal-title":"Neuron"},{"key":"2021031013283163300_ref30","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3389\/fncel.2014.00093","article-title":"Modulating excitation through plasticity at inhibitory synapses","volume":"8","author":"Chevaleyre","year":"2014","journal-title":"Front Cell Neurosci"},{"key":"2021031013283163300_ref31","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1073\/pnas.0915059107","article-title":"Plastic modifications induced by object recognition memory processing","volume":"107","author":"Clarke","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"2021031013283163300_ref32","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0893-133X(01)00221-4","article-title":"Extinction of cocaine self-administration produces a differential time-related regulation of proenkephalin gene expression in rat brain","volume":"25","author":"Crespo","year":"2001","journal-title":"Neuropsychopharmacology"},{"key":"2021031013283163300_ref33","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/S0169-328X(03)00316-4","article-title":"Extinction of cocaine self-administration produces alterations in corticotropin releasing factor gene expression in the paraventricular nucleus of the hypothalamus","volume":"117","author":"Crespo","year":"2003","journal-title":"Brain Res Mol Brain Res"},{"key":"2021031013283163300_ref34","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3389\/fnana.2015.00014","article-title":"The dendritic spine story: an intriguing process of discovery","volume":"9","author":"DeFelipe","year":"2015","journal-title":"Front Neuroanat"},{"key":"2021031013283163300_ref35","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1177\/41.5.8468459","article-title":"A simple and reliable method for correlative light and electron microscopic studies","volume":"41","author":"DeFelipe","year":"1993","journal-title":"J Histochem Cytochem"},{"key":"2021031013283163300_ref36","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/BF00247532","article-title":"A light and electron microscopic study of serotonin-immunoreactive fibers and terminals in the monkey sensory-motor cortex","volume":"71","author":"DeFelipe","year":"1988","journal-title":"Exp Brain Res"},{"key":"2021031013283163300_ref37","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1093\/cercor\/9.7.722","article-title":"Estimation of the number of synapses in the cerebral cortex: methodological considerations","volume":"9","author":"DeFelipe","year":"1999","journal-title":"Cereb Cortex"},{"key":"2021031013283163300_ref37a","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1023\/A:1024130211265","article-title":"Microstructure of the neocortex: comparative aspects","volume":"31","author":"DeFelipe","year":"2002","journal-title":"J Neurocytol"},{"key":"2021031013283163300_ref38","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.brainres.2006.07.001","article-title":"Enhancement of hippocampal long-term potentiation induced by cocaine self-administration is maintained during the extinction of this behavior","volume":"1116","author":"Del Olmo","year":"2006","journal-title":"Brain Res"},{"key":"2021031013283163300_ref39","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00213-007-0873-1","article-title":"Cocaine self-administration improves performance in a highly demanding water maze task","volume":"195","author":"Del Olmo","year":"2007","journal-title":"Psychopharmacology (Berl)"},{"key":"2021031013283163300_ref40","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0079-6123(00)25005-X","article-title":"Ultrastructural evidence for diffuse transmission by monoamine and acetylcholine neurons of the central nervous system","volume":"125","author":"Descarries","year":"2000","journal-title":"Prog Brain Res"},{"key":"2021031013283163300_ref41","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0140-19.2019","article-title":"3D electron microscopy study of synaptic Organization of the Normal Human Transentorhinal Cortex and its possible alterations in Alzheimer\u2019s disease","volume":"6","author":"Dom\u00ednguez-\u00c1lvaro","year":"2019","journal-title":"eNeuro"},{"key":"2021031013283163300_ref42","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s40478-018-0520-6","article-title":"Three-dimensional analysis of synapses in the transentorhinal cortex of Alzheimer\u2019s disease patients","volume":"6","author":"Dom\u00ednguez-\u00c1lvaro","year":"2018","journal-title":"Acta Neuropathol Commun"},{"key":"2021031013283163300_ref43","first-page":"838","article-title":"Development of synaptic boutons in layer 4 of the barrel field of the rat somatosensory cortex: a quantitative analysis","volume":"26","author":"Dufour","year":"2015","journal-title":"Cereb Cortex"},{"key":"2021031013283163300_ref44","doi-asserted-by":"crossref","first-page":"6957","DOI":"10.1523\/JNEUROSCI.5718-11.2012","article-title":"Subregional, dendritic compartment, and spine subtype specificity in cocaine regulation of dendritic spines in the nucleus accumbens","volume":"32","author":"Dumitriu","year":"2012","journal-title":"J Neurosci"},{"key":"2021031013283163300_ref45","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/0006-8993(95)00327-M","article-title":"Rat brain neurotransmitter turnover rates altered during withdrawal from chronic cocaine administration","volume":"682","author":"Dworkin","year":"1995","journal-title":"Brain Res"},{"key":"2021031013283163300_ref46","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3389\/fnana.2016.00075","article-title":"Opposing effects of neuronal activity on structural plasticity","volume":"10","author":"Fauth","year":"2016","journal-title":"Front Neuroanat"},{"key":"2021031013283163300_ref47","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1093\/cercor\/bhx011","article-title":"When and where learning is taking place: multisynaptic changes in strength during different behaviors related to the acquisition of an operant conditioning task by behaving rats","volume":"28","author":"Fern\u00e1ndez-Lamo","year":"2018","journal-title":"Cereb Cortex"},{"key":"2021031013283163300_ref48","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.nlm.2011.02.012","article-title":"Effects of chronic cocaine administration on spatial learning and hippocampal spine density in two genetically different strains of rats","volume":"95","author":"Fole","year":"2011","journal-title":"Neurobiol Learn Mem"},{"key":"2021031013283163300_ref49","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.euroneuro.2013.10.013","article-title":"Cocaine facilitates protein synthesis-dependent LTP: the role of metabotropic glutamate receptors","volume":"24","author":"Fole","year":"2014","journal-title":"Eu Neuropsychopharmacol"},{"key":"2021031013283163300_ref50","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.pnpbp.2017.02.024","article-title":"Lewis and Fischer 344 rats as a model for genetic differences in spatial learning and memory: cocaine effects","volume":"76","author":"Fole","year":"2017","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"2021031013283163300_ref51","volume-title":"Spatial statistics and modeling","author":"Gaetan","year":"2009"},{"key":"2021031013283163300_ref52","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/cne.10950","article-title":"Differences in the expression of AMPA and NMDA receptors between axospinous perforated and nonperforated synapses are related to the configuration and size of postsynaptic densities","volume":"468","author":"Ganeshina","year":"2004","journal-title":"J Comp Neurol"},{"key":"2021031013283163300_ref53","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.neuroscience.2004.02.025","article-title":"Synapses with a segmented, completely partitioned postsynaptic density express more AMPA receptors than other axospinous synaptic junctions","volume":"125","author":"Ganeshina","year":"2004","journal-title":"Neuroscience"},{"key":"2021031013283163300_ref54","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.biopsych.2019.03.982","article-title":"Extracellular matrix Signaling through \u03b23 integrin mediates cocaine cue\u2013induced transient synaptic plasticity and relapse","volume":"86","author":"Garcia-Keller","year":"2019","journal-title":"Biol Psychiatry"},{"key":"2021031013283163300_ref55","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/0006-8993(86)91486-1","article-title":"Aged rats need a preserved complement of perforated axospinous synapses per hippocampal neuron to maintain good spatial memory","volume":"398","author":"Geinisman","year":"1986","journal-title":"Brain Res"},{"key":"2021031013283163300_ref56","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.neuron.2013.01.005","article-title":"Relapse induced by cues predicting cocaine depends on rapid, transient synaptic potentiation","volume":"77","author":"Gipson","year":"2013","journal-title":"Neuron"},{"key":"2021031013283163300_ref57","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1523\/JNEUROSCI.2834-05.2006","article-title":"Involvement of the CA3-CA1 synapse in the acquisition of associative learning in behaving mice","volume":"26","author":"Gruart","year":"2006","journal-title":"J Neurosci"},{"key":"2021031013283163300_ref58","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1093\/cercor\/bhu054","article-title":"A differential and timed contribution of identified hippocampal synapses to associative learning in mice","volume":"25","author":"Gruart","year":"2015","journal-title":"Cereb Cortex"},{"key":"2021031013283163300_ref59","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1111\/j.1699-0463.1988.tb00954.x","article-title":"The new stereological tools: Disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis","volume":"96","author":"Gundersen","year":"1988","journal-title":"APMIS"},{"key":"2021031013283163300_ref60","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/nature11405","article-title":"An anatomically comprehensive atlas of the adult human brain transcriptome","volume":"489","author":"Hawrylycz","year":"2012","journal-title":"Nature"},{"key":"2021031013283163300_ref61","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s002130050365","article-title":"Differences in extracellular dopamine concentrations in the nucleus accumbens during response-dependent and response-independent cocaine administration in the rat","volume":"133","author":"Hemby","year":"1997","journal-title":"Psychopharmacology (Berl)"},{"key":"2021031013283163300_ref62","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1038\/nn.3137","article-title":"Release probability of hippocampal glutamatergic terminals scales with the size of the active zone","volume":"15","author":"Holderith","year":"2012","journal-title":"Nat Neurosci"},{"key":"2021031013283163300_ref63","volume-title":"Unbiased stereology: three-dimensional measurement in microscopy","author":"Howard","year":"2005"},{"key":"2021031013283163300_ref64","volume-title":"Statistical analysis and modelling of spatial point patterns","author":"Illian","year":"2008"},{"key":"2021031013283163300_ref65","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0006-8993(91)90312-J","article-title":"Perforated and non-perforated synapses in rat neocortex: three-dimensional reconstructions","volume":"556","author":"Jones","year":"1991","journal-title":"Brain Res"},{"key":"2021031013283163300_ref66","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1523\/JNEUROSCI.1013-12.2013","article-title":"Differential contribution of hippocampal circuits to appetitive and consummatory behaviors during operant conditioning of behaving mice","volume":"33","author":"Jurado-Parras","year":"2013","journal-title":"J Neurosci"},{"key":"2021031013283163300_ref67","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.cell.2015.06.054","article-title":"Saturated reconstruction of a volume of neocortex","volume":"162","author":"Kasthuri","year":"2015","journal-title":"Cell"},{"key":"2021031013283163300_ref68","doi-asserted-by":"crossref","first-page":"e05793","DOI":"10.7554\/eLife.05793","article-title":"Ultrastructural analysis of adult mouse neocortex comparing aldehyde perfusion with cryo fixation","volume":"4","author":"Korogod","year":"2015","journal-title":"Elife"},{"key":"2021031013283163300_ref69","doi-asserted-by":"crossref","first-page":"e25639","DOI":"10.1371\/journal.pone.0025639","article-title":"Dopamine-induced plasticity, phospholipase D (PLD) activity and cocaine-cue behavior depend on PLD-linked metabotropic glutamate receptors in amygdala","volume":"6","author":"Krishnan","year":"2011","journal-title":"PLoS One"},{"key":"2021031013283163300_ref70","doi-asserted-by":"crossref","first-page":"e46356","DOI":"10.7554\/eLife.46356","article-title":"Structural plasticity of dendritic secretory compartments during LTP-induced synaptogenesis","volume":"8","author":"Kulik","year":"2019","journal-title":"Elife"},{"key":"2021031013283163300_ref71","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1101\/lm.042192.116","article-title":"Effects of drugs of abuse on hippocampal plasticity and hippocampus-dependent learning and memory: contributions to development and maintenance of addiction","volume":"23","author":"Kutlu","year":"2016","journal-title":"Learn Mem"},{"key":"2021031013283163300_ref72","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1038\/nn1486","article-title":"Hebbian LTP in feed-forward inhibitory interneurons and the temporal fidelity of input discrimination","volume":"8","author":"Lamsa","year":"2005","journal-title":"Nat Neurosci"},{"key":"2021031013283163300_ref73","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1007\/s00213-006-0496-y","article-title":"Differential neurochemical and behavioral adaptation to cocaine after response contingent and noncontingent exposure in the rat","volume":"191","author":"Lecca","year":"2007","journal-title":"Psychopharmacology (Berl)"},{"key":"2021031013283163300_ref74","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1146\/annurev.psych.093008.100359","article-title":"Structural plasticity and hippocampal function","volume":"61","author":"Leuner","year":"2010","journal-title":"Annu Rev Psychol"},{"key":"2021031013283163300_ref75","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.cell.2004.11.003","article-title":"The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses","volume":"119","author":"Li","year":"2004","journal-title":"Cell"},{"key":"2021031013283163300_ref76","doi-asserted-by":"crossref","first-page":"20160260","DOI":"10.1098\/rstb.2016.0260","article-title":"Glutamatergic synapses are structurally and biochemically complex because of multiple plasticity processes: long-term potentiation, long-term depression, short-term potentiation and scaling","volume":"372","author":"Lisman","year":"2017","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"2021031013283163300_ref77","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1038\/nature04050","article-title":"Repeated cocaine exposure in vivo facilitates LTP induction in midbrain dopamine neurons","volume":"437","author":"Liu","year":"2005","journal-title":"Nature"},{"key":"2021031013283163300_ref78","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1093\/cercor\/bht336","article-title":"Age-related changes to layer 3 pyramidal cells in the rhesus monkey visual cortex","volume":"25","author":"Luebke","year":"2015","journal-title":"Cereb Cortex"},{"key":"2021031013283163300_ref79","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1126\/science.1204622","article-title":"Linking context with reward: a functional circuit from hippocampal CA3 to ventral tegmental area","volume":"333","author":"Luo","year":"2011","journal-title":"Science"},{"key":"2021031013283163300_ref80","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/s41583-020-0289-z","article-title":"The transition to compulsion in addiction","volume":"21","author":"L\u00fcscher","year":"2020","journal-title":"Nat Rev Neurosci"},{"key":"2021031013283163300_ref81","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1042\/AN20130015","article-title":"Drug-primed reinstatement of cocaine seeking in mice: increased excitability of medium-sized spiny neurons in the nucleus accumbens","volume":"5","author":"Ma","year":"2013","journal-title":"ASN Neuro"},{"key":"2021031013283163300_ref82","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1152\/jn.01009.2011","article-title":"Enhanced intrinsic excitability and EPSP-spike coupling accompany enriched environment-induced facilitation of LTP in hippocampal CA1 pyramidal neurons","volume":"107","author":"Malik","year":"2012","journal-title":"J Neurophysiol"},{"key":"2021031013283163300_ref83","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1152\/jn.1997.78.2.1030","article-title":"Sequence of single neuron changes in CA1 hippocampus of rabbits during acquisition of trace eyeblink conditioned responses","volume":"78","author":"McEchron","year":"1997","journal-title":"J Neurophysiol"},{"key":"2021031013283163300_ref84","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0306-4522(00)00496-6","article-title":"Total number and distribution of inhibitory and excitatory synapses on hippocampal CA1 pyramidal cells","volume":"102","author":"Meg\u00edas","year":"2001","journal-title":"Neuroscience"},{"key":"2021031013283163300_ref85","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3389\/neuro.05.018.2009","article-title":"Counting synapses using FIB\/SEM microscopy: a true revolution for ultrastructural volume reconstruction","volume":"3","author":"Merch\u00e1n-P\u00e9rez","year":"2009","journal-title":"Front Neuroanat"},{"key":"2021031013283163300_ref86","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1093\/cercor\/bht018","article-title":"Three-dimensional spatial distribution of synapses in the neocortex: a dual-beam electron microscopy study","volume":"24","author":"Merch\u00e1n-P\u00e9rez","year":"2014","journal-title":"Cereb Cortex"},{"key":"2021031013283163300_ref87","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1002\/(SICI)1096-9861(19960923)373:3<340::AID-CNE3>3.0.CO;2-2","article-title":"Quantitative aspects of synaptogenesis in the rat barrel field cortex with special reference to GABA circuitry","volume":"373","author":"Micheva","year":"1996","journal-title":"J Comp Neurol"},{"key":"2021031013283163300_ref88","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.neuroscience.2011.04.056","article-title":"Depotentiation of hippocampal long-term potentiation depends on genetic background and is modulated by cocaine self-administration","volume":"187","author":"Migu\u00e9ns","year":"2011","journal-title":"Neuroscience"},{"key":"2021031013283163300_ref89","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.neuropharm.2008.06.042","article-title":"Differential cocaine-induced modulation of glutamate and dopamine transporters after contingent and non-contingent administration","volume":"55","author":"Migu\u00e9ns","year":"2008","journal-title":"Neuropharmacology"},{"key":"2021031013283163300_ref90","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1093\/cercor\/bht200","article-title":"The effects of cocaine self-administration on dendritic spine density in the rat hippocampus are dependent on genetic background","volume":"25","author":"Migu\u00e9ns","year":"2015","journal-title":"Cereb Cortex"},{"key":"2021031013283163300_ref91","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.neubiorev.2012.01.002","article-title":"The persistence of maladaptive memory: addiction, drug memories and anti-relapse treatments","volume":"36","author":"Milton","year":"2012","journal-title":"Neurosci Biobehav Rev"},{"key":"2021031013283163300_ref92","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1080\/01913123.2016.1272665","article-title":"Stereological morphometric grids for ImageJ","volume":"41","author":"Mironov","year":"2017","journal-title":"Ultrastruct Pathol"},{"key":"2021031013283163300_ref93","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.neuron.2010.08.014","article-title":"Ultrastructural analysis of hippocampal neuropil from the connectomics perspective","volume":"67","author":"Mishchenko","year":"2010","journal-title":"Neuron"},{"key":"2021031013283163300_ref94","doi-asserted-by":"crossref","first-page":"e57013","DOI":"10.7554\/eLife.57013","article-title":"Three-dimensional synaptic organization of the human hippocampal CA1 field","volume":"9","author":"Montero-Crespo","year":"2020","journal-title":"Elife"},{"key":"2021031013283163300_ref95","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3389\/fnana.2011.00018","article-title":"Espina: a tool for the automated segmentation and counting of synapses in large stacks of electron microscopy images","volume":"5","author":"Morales","year":"2011","journal-title":"Front Neuroanat"},{"key":"2021031013283163300_ref96","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3389\/fnana.2013.00020","article-title":"Characterization and extraction of the synaptic apposition surface for synaptic geometry analysis","volume":"7","author":"Morales","year":"2013","journal-title":"Front Neuroanat"},{"key":"2021031013283163300_ref97","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1146\/annurev.neuro.31.061307.090723","article-title":"Place cells, grid cells, and the brain\u2019s spatial representation system","volume":"31","author":"Moser","year":"2008","journal-title":"Annu Rev Neurosci"},{"key":"2021031013283163300_ref98","doi-asserted-by":"crossref","first-page":"eaay3134","DOI":"10.1126\/science.aay3134","article-title":"Dense connectomic reconstruction in layer 4 of the somatosensory cortex","volume":"366","author":"Motta","year":"2019","journal-title":"Science"},{"key":"2021031013283163300_ref99","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1037\/bne0000079","article-title":"Hippocampectomy disrupts trace eye-blink conditioning in rabbits","volume":"129","author":"Moyer","year":"1990","journal-title":"Behav Neurosci"},{"key":"2021031013283163300_ref100","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/nn.3498","article-title":"Cocaine-induced structural plasticity in frontal cortex correlates with conditioned place preference","volume":"16","author":"Mu\u00f1oz-Cuevas","year":"2013","journal-title":"Nat Neurosci"},{"key":"2021031013283163300_ref101","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/nrn2303","article-title":"Synaptic plasticity, memory and the hippocampus: a neural network approach to causality","volume":"9","author":"Neves","year":"2008","journal-title":"Nat Rev Neurosci"},{"key":"2021031013283163300_ref102","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.neuropharm.2011.03.010","article-title":"Natural rewards, neuroplasticity, and non-drug addictions","volume":"61","author":"Olsen","year":"2011","journal-title":"Neuropharmacology"},{"key":"2021031013283163300_ref103","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/0301-0082(91)90007-N","article-title":"Neurite growth from, and neuronal survival within, cultured explants of the nervous system: a critical review of morphometric and stereological methods, and suggestions for the future","volume":"37","author":"Oorschot","year":"1991","journal-title":"Prog Neurobiol"},{"key":"2021031013283163300_ref104","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1523\/JNEUROSCI.18-04-01270.1998","article-title":"D1\/D5 dopamine receptors inhibit depotentiation at CA1 synapses via cAMP-dependent mechanism","volume":"18","author":"Otmakhova","year":"1998","journal-title":"J Neurosci"},{"key":"2021031013283163300_ref105","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1007\/s00213-017-4798-z","article-title":"Contributions of prolonged contingent and non-contingent cocaine exposure to escalation of cocaine intake and glutamatergic gene expression","volume":"235","author":"Ploense","year":"2018","journal-title":"Psychopharmacology (Berl)"},{"key":"2021031013283163300_ref106","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.pharep.2017.04.016","article-title":"Neuroadaptive changes in metabotropic glutamate mGlu2\/3R expression during different phases of cocaine addiction in rats","volume":"69","author":"Pomierny-Chamiolo","year":"2017","journal-title":"Pharmacol Rep"},{"key":"2021031013283163300_ref107","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1007\/s12640-014-9502-z","article-title":"Withdrawal from cocaine self-administration and yoked cocaine delivery dysregulates glutamatergic mGlu5 and NMDA receptors in the rat brain","volume":"27","author":"Pomierny-Chamiolo","year":"2015","journal-title":"Neurotox Res"},{"key":"2021031013283163300_ref108","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.neuroscience.2009.03.061","article-title":"Genetic differences in hippocampal synaptic plasticity","volume":"161","author":"Prakash","year":"2009","journal-title":"Neuroscience"},{"key":"2021031013283163300_ref109","doi-asserted-by":"crossref","first-page":"11897","DOI":"10.1523\/JNEUROSCI.4961-14.2015","article-title":"The contingency of cocaine administration accounts for structural and functional medial prefrontal deficits and increased adrenocortical activation","volume":"35","author":"Radley","year":"2015","journal-title":"J Neurosci"},{"key":"2021031013283163300_ref110","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/1098-2396(20010301)39:3<257::AID-SYN1007>3.0.CO;2-1","article-title":"Cocaine self-administration alters the morphology of dendrites and dendritic spines in the nucleus accumbens and neocortex","volume":"39","author":"Robinson","year":"2001","journal-title":"Synapse"},{"key":"2021031013283163300_ref111","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.neuropharm.2004.06.025","article-title":"Structural plasticity associated with exposure to drugs of abuse","volume":"47","author":"Robinson","year":"2004","journal-title":"Neuropharmacology"},{"key":"2021031013283163300_ref112","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.tins.2010.02.002","article-title":"The addicted synapse: mechanisms of synaptic and structural plasticity in nucleus accumbens","volume":"33","author":"Russo","year":"2010","journal-title":"Trends Neurosci"},{"key":"2021031013283163300_ref113","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s00429-017-1470-7","article-title":"Volume electron microscopy of the distribution of synapses in the neuropil of the juvenile rat somatosensory cortex","volume":"223","author":"Santuy","year":"2018","journal-title":"Brain Struct Funct"},{"key":"2021031013283163300_ref114","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0377-17.2017","article-title":"Study of the size and shape of synapses in the juvenile rat somatosensory cortex with 3D electron microscopy","volume":"5","author":"Santuy","year":"2018","journal-title":"eNeuro"},{"key":"2021031013283163300_ref115","doi-asserted-by":"crossref","first-page":"14014","DOI":"10.1038\/s41598-020-70859-5","article-title":"Estimation of the number of synapses in the hippocampus and brain-wide by volume electron microscopy and genetic labeling","volume":"10","author":"Santuy","year":"2020","journal-title":"Sci Rep"},{"key":"2021031013283163300_ref116","doi-asserted-by":"crossref","first-page":"3673","DOI":"10.1093\/cercor\/bhy159","article-title":"A quantitative study on the distribution of mitochondria in the neuropil of the juvenile rat somatosensory cortex","volume":"28","author":"Santuy","year":"2018","journal-title":"Cereb Cortex"},{"key":"2021031013283163300_ref117","doi-asserted-by":"crossref","first-page":"5858","DOI":"10.1523\/JNEUROSCI.17-15-05858.1997","article-title":"Quantitative ultrastructural analysis of hippocampal excitatory synapses","volume":"17","author":"Schikorski","year":"1997","journal-title":"J Neurosci"},{"key":"2021031013283163300_ref118","doi-asserted-by":"crossref","first-page":"4107","DOI":"10.1073\/pnas.96.7.4107","article-title":"Quantitative fine-structural analysis of olfactory cortical synapses","volume":"96","author":"Schikorski","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"2021031013283163300_ref119","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/adb.12294","article-title":"Rat-strain dependent changes of dendritic and spine morphology in the hippocampus after cocaine self-administration","volume":"22","author":"Selvas","year":"2017","journal-title":"Addict Biol"},{"key":"2021031013283163300_ref120","article-title":"Your Chi-Square test is statistically significant: now what?","volume":"20","author":"Sharpe","year":"2015","journal-title":"Pract Assess Res Eval"},{"key":"2021031013283163300_ref121","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s00429-011-0322-0","article-title":"Hippocampal pyramidal cells: the reemergence of cortical lamination","volume":"216","author":"Slomianka","year":"2011","journal-title":"Brain Struct Funct"},{"key":"2021031013283163300_ref122","doi-asserted-by":"crossref","first-page":"247","DOI":"10.31887\/DCNS.2017.19.3\/rspanagel","article-title":"Animal models of addiction","volume":"19","author":"Spanagel","year":"2017","journal-title":"Dialogues Clin Neurosci"},{"key":"2021031013283163300_ref123","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/452420a","article-title":"Neuroscience: strength in numbers","volume":"452","author":"Spruston","year":"2008","journal-title":"Nature"},{"key":"2021031013283163300_ref124","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2007.04.074","article-title":"Active versus passive cocaine administration: differences in the neuroadaptive changes in the brain dopaminergic system","volume":"1157","author":"Stefa\u0144ski","year":"2007","journal-title":"Brain Res"},{"key":"2021031013283163300_ref125","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1038\/npp.2015.345","article-title":"Cell-type specific insertion of GluA2-lacking AMPARs with cocaine exposure leading to sensitization, cue-induced seeking, and incubation of craving","volume":"41","author":"Terrier","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"2021031013283163300_ref126","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/S0028-3908(02)00059-X","article-title":"Enhancement of long-term potentiation in the rat hippocampus following cocaine exposure","volume":"42","author":"Thompson","year":"2002","journal-title":"Neuropharmacology"},{"key":"2021031013283163300_ref127","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s00213-003-1734-1","article-title":"Effects of persistent cocaine self-administration on amygdala-dependent and dorsal striatum-dependent learning in rats","volume":"174","author":"Udo","year":"2004","journal-title":"Psychopharmacology (Berl)"},{"key":"2021031013283163300_ref128","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1146\/annurev.psych.093008.100523","article-title":"Hippocampal-neocortical interactions in memory formation, consolidation, and reconsolidation","volume":"61","author":"Wang","year":"2010","journal-title":"Annu Rev Psychol"},{"key":"2021031013283163300_ref129","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1126\/science.1128134","article-title":"Learning induces long-term potentiation in the hippocampus","volume":"313","author":"Whitlock","year":"2006","journal-title":"Science"},{"key":"2021031013283163300_ref130","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0006-8993(94)90508-8","article-title":"Amygdala dopamine levels are markedly elevated after self- but not passive-administration of cocaine","volume":"668","author":"Wilson","year":"1994","journal-title":"Brain Res"},{"key":"2021031013283163300_ref131","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1016\/j.euroneuro.2016.08.013","article-title":"Response contingency directs long-term cocaine-induced neuroplasticity in prefrontal and striatal dopamine terminals","volume":"26","author":"Wiskerke","year":"2016","journal-title":"Eur Neuropsychopharmacol"},{"key":"2021031013283163300_ref132","first-page":"5463","article-title":"Enduring loss of serotonergic control of orbitofrontal cortex function following contingent and noncontingent cocaine exposure","volume":"27","author":"Wright","year":"2017","journal-title":"Cereb Cortex"},{"key":"2021031013283163300_ref133","doi-asserted-by":"crossref","first-page":"e48373","DOI":"10.7554\/eLife.48373","article-title":"Ultrastructural heterogeneity of layer 4 excitatory synaptic boutons in the adult human temporal lobe neocortex","volume":"8","author":"Yakoubi","year":"2019","journal-title":"Elife"}],"container-title":["Cerebral Cortex"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cercor\/article-pdf\/31\/4\/1927\/36458437\/bhaa331.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/cercor\/article-pdf\/31\/4\/1927\/36458437\/bhaa331.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T08:31:19Z","timestamp":1615365079000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cercor\/article\/31\/4\/1927\/6012767"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,30]]},"references-count":134,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,11,30]]},"published-print":{"date-parts":[[2021,3,5]]}},"URL":"https:\/\/doi.org\/10.1093\/cercor\/bhaa331","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.04.23.050575","asserted-by":"object"}]},"ISSN":["1047-3211","1460-2199"],"issn-type":[{"value":"1047-3211","type":"print"},{"value":"1460-2199","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,4,1]]},"published":{"date-parts":[[2020,11,30]]}}}