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The goal of these studies was to address the direct impact of Zika virus on fetal development by inoculating early gestation fetal rhesus monkeys using an ultrasound-guided approach (intraperitoneal vs. intraventricular). Growth and development were monitored across gestation, maternal samples collected, and fetal tissues obtained in the second trimester or near term. Although normal growth and anatomical development were observed, significant morphologic changes were noted in the cerebral cortex at 3-weeks post-Zika virus inoculation including massive alterations in the distribution, density, number, and morphology of microglial cells in proliferative regions of the fetal cerebral cortex; an altered distribution of Tbr2+ neural precursor cells; increased diameter and volume of blood vessels in the cortical proliferative zones; and a thinner cortical plate. At 3-months postinoculation, alterations in morphology, distribution, and density of microglial cells were also observed with an increase in blood vessel volume; and a thinner cortical plate. Only transient maternal viremia was observed but sustained maternal immune activation was detected. Overall, these studies suggest persistent changes in cortical structure result from early gestation Zika virus exposure with durable effects on microglial cells.<\/jats:p>","DOI":"10.1093\/cercor\/bhaa336","type":"journal-article","created":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T11:21:54Z","timestamp":1603192914000},"page":"2309-2321","source":"Crossref","is-referenced-by-count":12,"title":["Fetal Rhesus Monkey First Trimester Zika Virus Infection Impacts Cortical Development in the Second and Third Trimesters"],"prefix":"10.1093","volume":"31","author":[{"given":"Alice F","family":"Tarantal","sequence":"first","affiliation":[{"name":"Department of Pediatrics, School of Medicine, University of California, Davis, Davis, CA 95616, USA"},{"name":"Department of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis, Davis, CA 95616, USA"},{"name":"California National Primate Research Center, University of California, Davis, Davis, CA 95616, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis J","family":"Hartigan-O\u2019Connor","sequence":"additional","affiliation":[{"name":"California National Primate Research Center, University of California, Davis, Davis, CA 95616, USA"},{"name":"Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, Davis, CA 95616, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7057-3566","authenticated-orcid":false,"given":"Elisa","family":"Penna","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Science, School of Medicine, University of California, Davis, Davis, CA 95817, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Kreutz","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Science, School of Medicine, University of California, Davis, Davis, CA 95817, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele L","family":"Martinez","sequence":"additional","affiliation":[{"name":"California National Primate Research Center, University of California, Davis, Davis, CA 95616, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen C","family":"Noctor","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Science, School of Medicine, University of California, Davis, Davis, CA 95817, USA"},{"name":"MIND Institute, School of Medicine, University of California, Davis, Davis, CA 95817, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,12,21]]},"reference":[{"key":"2021040620011364300_ref1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.antiviral.2017.06.001","article-title":"Zika in the Americas in year 2: what have we learned? 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