{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T13:36:07Z","timestamp":1768743367179,"version":"3.49.0"},"reference-count":70,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T00:00:00Z","timestamp":1614124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["093104"],"award-info":[{"award-number":["093104"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/F021399\/1"],"award-info":[{"award-number":["BB\/F021399\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/P013031\/1"],"award-info":[{"award-number":["MR\/P013031\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Top-down attention, controlled by frontal cortical areas, is a key component of cognitive operations. How different neurotransmitters and neuromodulators flexibly change the cellular and network interactions with attention demands remains poorly understood. While acetylcholine and dopamine are critically involved, glutamatergic receptors have been proposed to play important roles. To understand their contribution to attentional signals, we investigated how ionotropic glutamatergic receptors in the frontal eye field (FEF) of male macaques contribute to neuronal excitability and attentional control signals in different cell types. Broad-spiking and narrow-spiking cells both required N-methyl-D-aspartic acid and \u03b1-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor activation for normal excitability, thereby affecting ongoing or stimulus-driven activity. However, attentional control signals were not dependent on either glutamatergic receptor type in broad- or narrow-spiking cells. A further subdivision of cell types into different functional types using cluster-analysis based on spike waveforms and spiking characteristics did not change the conclusions. This can be explained by a model where local blockade of specific ionotropic receptors is compensated by cell embedding in large-scale networks. It sets the glutamatergic system apart from the cholinergic system in FEF and demonstrates that a reduction in excitability is not sufficient to induce a reduction in attentional control signals.<\/jats:p>","DOI":"10.1093\/cercor\/bhab007","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T20:21:44Z","timestamp":1610742104000},"page":"3266-3284","source":"Crossref","is-referenced-by-count":5,"title":["Contribution of Ionotropic Glutamatergic Receptors to Excitability and Attentional Signals in Macaque Frontal Eye Field"],"prefix":"10.1093","volume":"31","author":[{"given":"Miguel","family":"Dasilva","sequence":"first","affiliation":[{"name":"Institute of Neuroscience, Newcastle University, Newcastle upon Tyne NE2 4HH, UK"},{"name":"College of Medicine and Health, University of Exeter, EX1 2LU, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Brandt","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience, Newcastle University, Newcastle upon Tyne NE2 4HH, UK"},{"name":"Institute of Clinical Research, University of Southern Denmark, DK-5230 Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Alwin Gieselmann","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience, Newcastle University, Newcastle upon Tyne NE2 4HH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Distler","sequence":"additional","affiliation":[{"name":"Allgemeine Zoologie und Neurobiologie, Ruhr-Universit\u00e4t Bochum, Bochum 44801 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4894-0213","authenticated-orcid":false,"given":"Alexander","family":"Thiele","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience, Newcastle University, Newcastle upon Tyne NE2 4HH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,2,24]]},"reference":[{"key":"2021061207382653300_ref1","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1523\/JNEUROSCI.2700-14.2015","article-title":"Mapping of functionally characterized cell classes onto canonical circuit operations in primate prefrontal cortex","volume":"35","author":"Ardid","year":"2015","journal-title":"J Neurosci"},{"key":"2021061207382653300_ref2","doi-asserted-by":"crossref","first-page":"15621","DOI":"10.1523\/JNEUROSCI.4465-09.2009","article-title":"Selection and maintenance of spatial information by frontal eye field neurons","volume":"29","author":"Armstrong","year":"2009","journal-title":"J Neurosci"},{"key":"2021061207382653300_ref3","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.neuron.2015.10.001","article-title":"A source for feature-based attention in the prefrontal cortex","volume":"88","author":"Bichot","year":"2015","journal-title":"Neuron"},{"key":"2021061207382653300_ref4","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1017\/S095252380000715X","article-title":"A relationship between behavioral choice and the visual responses of neurons in macaque MT","volume":"13","author":"Britten","year":"1996","journal-title":"Vis Neurosci"},{"key":"2021061207382653300_ref5","doi-asserted-by":"crossref","first-page":"4745","DOI":"10.1523\/JNEUROSCI.12-12-04745.1992","article-title":"The analysis of visual motion: a comparison of neuronal and psychophysical performance","volume":"12","author":"Britten","year":"1992","journal-title":"J Neurosci"},{"key":"2021061207382653300_ref6","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1152\/jn.1985.54.3.714","article-title":"Primate frontal eye fields. 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