{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T03:48:27Z","timestamp":1793245707449,"version":"4.5.0"},"reference-count":66,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T00:00:00Z","timestamp":1617753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/M00693X\/1"],"award-info":[{"award-number":["BB\/M00693X\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015504","name":"Simons Initiative for the Developing Brain","doi-asserted-by":"publisher","award":["529085"],"award-info":[{"award-number":["529085"]}],"id":[{"id":"10.13039\/501100015504","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Joint Medical Research Council","award":["MR\/R006237\/1"],"award-info":[{"award-number":["MR\/R006237\/1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The 593 kbp 16p11.2 copy number variation (CNV) affects the gene dosage of 29 protein coding genes, with heterozygous 16p11.2 microduplication or microdeletion implicated in about 1% of autism spectrum disorder (ASD) cases. The 16p11.2 CNV is frequently associated with macrocephaly or microcephaly indicating early defects of neurogenesis may contribute to subsequent ASD symptoms, but it is unknown which 16p11.2 transcripts are expressed in progenitors and whose levels are likely, therefore, to influence neurogenesis. Analysis of human fetal gene expression data revealed that KIF22, ALDOA, HIRIP3, PAGR1, and MAZ transcripts are expressed in neural progenitors with ALDOA and KIF22 significantly enriched compared to post-mitotic cells. To investigate the possible roles of ALDOA and KIF22 proteins in human cerebral cortex development we used immunohistochemical staining to describe their expression in late first and early second trimester human cerebral cortex. KIF22 protein is restricted to proliferating cells with its levels increasing during the cell cycle and peaking at mitosis. ALDOA protein is expressed in all cell types and does not vary with cell-cycle phase. Our expression analysis suggests the hypothesis that altered neurogenesis in the cerebral cortex contributes to ASD in 16p11.2 CNV patients.<\/jats:p>","DOI":"10.1093\/cercor\/bhab067","type":"journal-article","created":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T20:11:09Z","timestamp":1614888669000},"page":"4038-4052","source":"Crossref","is-referenced-by-count":21,"title":["Expression of Genes in the <i>16p11.2<\/i> Locus during Development of the Human Fetal Cerebral Cortex"],"prefix":"10.1093","volume":"31","author":[{"given":"Sarah","family":"Morson","sequence":"first","affiliation":[{"name":"Simons Initiative for the Developing Brain, Hugh Robson Building, Edinburgh Medical School Biomedical Sciences, The University of Edinburgh, Edinburgh EH8 9XD, UK"},{"name":"Centre for Discovery Brain Sciences, Hugh Robson Building, Edinburgh Medical School Biomedical Sciences, The University of Edinburgh, Edinburgh EH8 9XD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Yang","sequence":"additional","affiliation":[{"name":"Simons Initiative for the Developing Brain, Hugh Robson Building, Edinburgh Medical School Biomedical Sciences, The University of Edinburgh, Edinburgh EH8 9XD, UK"},{"name":"Centre for Discovery Brain Sciences, Hugh Robson Building, Edinburgh Medical School Biomedical Sciences, The University of Edinburgh, Edinburgh EH8 9XD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J","family":"Price","sequence":"additional","affiliation":[{"name":"Simons Initiative for the Developing Brain, Hugh Robson Building, Edinburgh Medical School Biomedical Sciences, The University of Edinburgh, Edinburgh EH8 9XD, UK"},{"name":"Centre for Discovery Brain Sciences, Hugh Robson Building, Edinburgh Medical School Biomedical Sciences, The University of Edinburgh, Edinburgh EH8 9XD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Pratt","sequence":"additional","affiliation":[{"name":"Simons Initiative for the Developing Brain, Hugh Robson Building, Edinburgh Medical School Biomedical Sciences, The University of Edinburgh, Edinburgh EH8 9XD, UK"},{"name":"Centre for Discovery Brain Sciences, Hugh Robson Building, Edinburgh Medical School Biomedical Sciences, The University of Edinburgh, Edinburgh EH8 9XD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,4,7]]},"reference":[{"key":"2021080216411189700_ref1","volume-title":"The Human Brain During the Late First Trimester","author":"Bayer","year":"2002"},{"key":"2021080216411189700_ref2","doi-asserted-by":"crossref","DOI":"10.1201\/9780203507483","volume-title":"The Human Brain During The Second Trimester","author":"Bayer","year":"2005"},{"key":"2021080216411189700_ref3","doi-asserted-by":"crossref","first-page":"3414","DOI":"10.1002\/pmic.200500069","article-title":"Proteomic analysis of the anterior cingulate cortex in the major psychiatric disorders: evidence for disease-associated changes","volume":"6","author":"Beasley","year":"2006","journal-title":"Proteomics"},{"key":"2021080216411189700_ref4","first-page":"154","article-title":"Red cell aldolase deficiency and hemolytic anemia: a new syndrome","volume":"86","author":"Beutler","year":"1973","journal-title":"Trans Assoc Am Physicians"},{"key":"2021080216411189700_ref5","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ejmg.2009.03.006","article-title":"Extending the phenotype of recurrent rearrangements of 16p11.2: deletions in mentally retarded patients without autism and in normal individuals","volume":"52","author":"Bijlsma","year":"2009","journal-title":"Eur J Med Genet"},{"key":"2021080216411189700_ref6","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1093\/cercor\/bhx143","article-title":"Focal cortical anomalies and language impairment in 16p11.2 deletion and duplication syndrome","volume":"28","author":"Blackmon","year":"2018","journal-title":"Cereb Cortex"},{"key":"2021080216411189700_ref7","first-page":"834","article-title":"Zebrafish homologs of genes within 16p11.2, a genomic region associated with brain disorders, are active during brain development, and include two deletion dosage sensor genes","volume":"5","author":"Blaker-Lee","year":"2012","journal-title":"Dis Model Mech"},{"key":"2021080216411189700_ref8","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.ajhg.2014.05.004","article-title":"Transcriptional consequences of 16p11.2 deletion and duplication in mouse cortex and multiplex autism families","volume":"94","author":"Blumenthal","year":"2014","journal-title":"Am J Hum Genet"},{"key":"2021080216411189700_ref9","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.neures.2014.04.004","article-title":"Mechanisms of brain evolution: regulation of neural progenitor cell diversity and cell cycle length","volume":"86","author":"Borrell","year":"2014","journal-title":"Neurosci Res"},{"key":"2021080216411189700_ref10","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3389\/fncel.2015.00257","article-title":"Physical biology of human brain development","volume":"9","author":"Budday","year":"2015","journal-title":"Front Cell Neurosci"},{"key":"2021080216411189700_ref11","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1074\/jbc.M506346200","article-title":"Characterization of an aldolase-binding site in the Wiskott-Aldrich syndrome protein","volume":"281","author":"Buscaglia","year":"2006","journal-title":"J Biol Chem"},{"key":"2021080216411189700_ref12","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/nrn2252","article-title":"Development of the human cerebral cortex: boulder committee revisited","volume":"9","author":"Bystron","year":"2008","journal-title":"Nat Rev Neurosci"},{"key":"2021080216411189700_ref13","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/j.1469-7580.2010.01281.x","article-title":"Renewed focus on the developing human neocortex","volume":"217","author":"Clowry","year":"2010","journal-title":"J Anat"},{"key":"2021080216411189700_ref14","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1038\/nn.3141","article-title":"Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex","volume":"15","author":"Anda","year":"2012","journal-title":"Nat Neurosci"},{"key":"2021080216411189700_ref15","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nature24470","article-title":"Kctd 13 deletion reduces synaptic transmission via increased rho a","volume":"551","author":"Escamilla","year":"2017","journal-title":"Nature"},{"key":"2021080216411189700_ref16","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s40880-018-0290-3","article-title":"Aldolase a promotes proliferation and G1\/S transition via the EGFR\/MAPK pathway in non-small cell lung cancer","volume":"38","author":"Fu","year":"2018","journal-title":"Cancer Commun"},{"key":"2021080216411189700_ref17","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1111\/joa.12959","article-title":"The potential contribution of impaired brain glucose metabolism to congenital Zika syndrome","volume":"235","author":"Gilbert-Jaramillo","year":"2019","journal-title":"J Anat"},{"key":"2021080216411189700_ref18","doi-asserted-by":"crossref","first-page":"R176","DOI":"10.1093\/hmg\/ddq366","article-title":"Phenotypic variability and genetic susceptibility to genomic disorders","volume":"19","author":"Girirajan","year":"2010","journal-title":"Hum Mol Genet"},{"key":"2021080216411189700_ref19","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/nature11091","article-title":"KCTD13 is a major driver of mirrored neuroanatomical phenotypes of the 16p11.2 copy number variant","volume":"485","author":"Golzio","year":"2012","journal-title":"Nature"},{"key":"2021080216411189700_ref20","first-page":"618","article-title":"Neonatal energy substrate production","volume":"130","author":"Gustafsson","year":"2009","journal-title":"Indian J Med Res"},{"key":"2021080216411189700_ref21","doi-asserted-by":"crossref","first-page":"17076","DOI":"10.1073\/pnas.1114042108","article-title":"Dosage-dependent phenotypes in models of 16p11.2 lesions found in autism","volume":"108","author":"Horev","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2021080216411189700_ref22","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/S1097-2765(03)00113-8","article-title":"Aldolase forms a bridge between cell surface adhesins and the actin cytoskeleton in apicomplexan parasites","volume":"11","author":"Jewett","year":"2003","journal-title":"Mol Cell"},{"key":"2021080216411189700_ref23","doi-asserted-by":"crossref","first-page":"17742","DOI":"10.1074\/jbc.274.25.17742","article-title":"Aldolase mediates the association of F-actin with the insulin-responsive glucose transporter GLUT4","volume":"274","author":"Kao","year":"1999","journal-title":"J Biol Chem"},{"key":"2021080216411189700_ref24","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1056\/NEJM199604253341705","article-title":"Brief report: inherited metabolic myopathy and hemolysis due to a mutation in aldolase a","volume":"334","author":"Kreuder","year":"1996","journal-title":"N Engl J Med"},{"key":"2021080216411189700_ref25","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1093\/hmg\/ddm376","article-title":"Recurrent 16p11.2 microdeletions in autism","volume":"17","author":"Kumar","year":"2008","journal-title":"Hum Mol Genet"},{"key":"2021080216411189700_ref26","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.neuron.2011.05.015","article-title":"Rare de novo and transmitted copy-number variation in autistic spectrum disorders","volume":"70","author":"Levy","year":"2011","journal-title":"Neuron"},{"key":"2021080216411189700_ref27","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1038\/nn.3536","article-title":"Subcortical origins of human and monkey neocortical interneurons","volume":"16","author":"Ma","year":"2013","journal-title":"Nat Neurosci"},{"key":"2021080216411189700_ref28","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.cell.2015.05.002","article-title":"Highly parallel genome-wide expression profiling of individual cells using Nanoliter droplets","volume":"161","author":"Macosko","year":"2015","journal-title":"Cell"},{"key":"2021080216411189700_ref29","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/j.cell.2012.02.039","article-title":"CNVs: harbingers of a rare variant revolution in psychiatric genetics","volume":"148","author":"Malhotra","year":"2012","journal-title":"Cell"},{"key":"2021080216411189700_ref30","doi-asserted-by":"crossref","first-page":"799","DOI":"10.18388\/abp.2008_3043","article-title":"Aldolase a is present in smooth muscle cell nuclei","volume":"55","author":"Mamczur","year":"2008","journal-title":"Acta Biochim Pol"},{"key":"2021080216411189700_ref31","doi-asserted-by":"crossref","first-page":"2812","DOI":"10.1016\/j.bbamcr.2013.07.013","article-title":"Nuclear localization of aldolase a correlates with cell proliferation","volume":"1833","author":"Mamczur","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"2021080216411189700_ref32","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s00441-010-1008-2","article-title":"Ubiquitous presence of gluconeogenic regulatory enzyme, fructose-1,6-bisphosphatase, within layers of rat retina","volume":"341","author":"Mamczur","year":"2010","journal-title":"Cell Tissue Res"},{"key":"2021080216411189700_ref33","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1038\/ng.474","article-title":"Microduplications of 16p11.2 are associated with schizophrenia","volume":"41","author":"Wellcome Trust Case Control Consortium, Wellcome Trust Case Control Consortium","year":"2009","journal-title":"Nat Genet"},{"key":"2021080216411189700_ref34","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.celrep.2018.06.110","article-title":"Ki67 is a graded rather than a binary marker of proliferation versus quiescence","volume":"24","author":"Miller","year":"2018","journal-title":"Cell Rep"},{"key":"2021080216411189700_ref35","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/978-1-4615-4253-7_10","article-title":"Cell cycle regulation by the Cdc25 phosphatase family","volume":"4","author":"Nilsson","year":"2000","journal-title":"Prog Cell Cycle Res"},{"key":"2021080216411189700_ref36","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nature19075","article-title":"Emergence of a Homo sapiens-specific gene family and chromosome 16p11.2 CNV susceptibility","volume":"536","author":"Nuttle","year":"2016","journal-title":"Nature"},{"key":"2021080216411189700_ref37","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1093\/emboj\/cdg208","article-title":"Cdc2-mediated phosphorylation of kid controls its distribution to spindle and chromosomes","volume":"22","author":"Ohsugi","year":"2003","journal-title":"EMBO J"},{"key":"2021080216411189700_ref38","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0167-4838(88)90286-5","article-title":"Modulation of phosphofructokinase action by macromolecular interactions. Quantitative analysis of the phosphofructokinase-aldolase-calmodulin system","volume":"957","author":"Orosz","year":"1988","journal-title":"Biochim Biophys Acta"},{"key":"2021080216411189700_ref39","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1083\/jcb.118.4.859","article-title":"2-Deoxyglucose and cytochalasin D modulate aldolase mobility in living 3T3 cells","volume":"118","author":"Pagliaro","year":"1992","journal-title":"J Cell Biol"},{"key":"2021080216411189700_ref40","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.cell.2019.01.017","article-title":"Establishing cerebral organoids as models of human-specific brain evolution","volume":"176","author":"Pollen","year":"2019","journal-title":"Cell"},{"key":"2021080216411189700_ref41","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.cell.2015.09.004","article-title":"Molecular identity of human outer radial glia during cortical development","volume":"163","author":"Pollen","year":"2015","journal-title":"Cell"},{"key":"2021080216411189700_ref42","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1093\/bioinformatics\/btp184","article-title":"Globally optimal stitching of tiled 3D microscopic image acquisitions","volume":"25","author":"Preibisch","year":"2009","journal-title":"Bioinformatics"},{"key":"2021080216411189700_ref43","doi-asserted-by":"crossref","first-page":"6640","DOI":"10.1523\/JNEUROSCI.0515-17.2018","article-title":"Pharmacological inhibition of ERK Signaling rescues pathophysiology and Behavioral phenotype associated with 16p11.2 chromosomal deletion in mice","volume":"38","author":"Pucilowska","year":"2018","journal-title":"J Neurosci"},{"key":"2021080216411189700_ref44","doi-asserted-by":"crossref","first-page":"3190","DOI":"10.1523\/JNEUROSCI.4864-13.2015","article-title":"The 16p11.2 deletion mouse model of autism exhibits altered cortical progenitor proliferation and brain cytoarchitecture linked to the ERK MAPK pathway","volume":"35","author":"Pucilowska","year":"2015","journal-title":"J Neurosci"},{"key":"2021080216411189700_ref45","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nmeth.4150","article-title":"Single-cell mRNA quantification and differential analysis with census","volume":"14","author":"Qiu","year":"2017","journal-title":"Nat Methods"},{"key":"2021080216411189700_ref46","doi-asserted-by":"crossref","first-page":"11199","DOI":"10.1523\/JNEUROSCI.1366-14.2014","article-title":"Opposing brain differences in 16p11.2 deletion and duplication carriers","volume":"34","author":"Qureshi","year":"2014","journal-title":"J Neurosci"},{"key":"2021080216411189700_ref47","first-page":"82","article-title":"The complexity of the calretinin-expressing progenitors in the human cerebral cortex","volume":"8","author":"Radonji\u0107","year":"2014","journal-title":"Front Neuroanat"},{"key":"2021080216411189700_ref48","doi-asserted-by":"crossref","first-page":"10142","DOI":"10.1073\/pnas.1808066115","article-title":"Metabolic regulation and glucose sensitivity of cortical radial glial cells","volume":"115","author":"Rash","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2021080216411189700_ref49","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1038\/s41380-018-0025-5","article-title":"Altered TAOK2 activity causes autism-related neurodevelopmental and cognitive abnormalities through RhoA signaling","volume":"24","author":"Richter","year":"2019","journal-title":"Mol Psychiatry"},{"key":"2021080216411189700_ref50","doi-asserted-by":"crossref","first-page":"42554","DOI":"10.1074\/jbc.M112.405969","article-title":"Targeting of several glycolytic enzymes using RNA interference reveals aldolase affects cancer cell proliferation through a non-glycolytic mechanism","volume":"287","author":"Ritterson Lew","year":"2012","journal-title":"J Biol Chem"},{"key":"2021080216411189700_ref51","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s11689-009-9037-4","article-title":"Speech delays and behavioral problems are the predominant features in individuals with developmental delays and 16p11.2 microdeletions and microduplications","volume":"2","author":"Rosenfeld","year":"2010","journal-title":"J Neurodev Disord"},{"key":"2021080216411189700_ref52","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.neuron.2011.05.002","article-title":"Multiple recurrent de novo CNVs, including duplications of the 7q11.23 Williams syndrome region, are strongly associated with autism","volume":"70","author":"Sanders","year":"2011","journal-title":"Neuron"},{"key":"2021080216411189700_ref53","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/(SICI)1097-4652(200003)182:3<311::AID-JCP1>3.0.CO;2-9","article-title":"The Ki-67 protein: from the known and the unknown","volume":"182","author":"Scholzen","year":"2000","journal-title":"J Cell Physiol"},{"key":"2021080216411189700_ref54","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1136\/jmg.2009.073015","article-title":"Recurrent reciprocal 16p11.2 rearrangements associated with global developmental delay, behavioural problems, dysmorphism, epilepsy, and abnormal head size","volume":"47","author":"Shinawi","year":"2010","journal-title":"J Med Genet"},{"key":"2021080216411189700_ref55","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/nrn3707","article-title":"Growth and folding of the mammalian cerebral cortex: from molecules to malformations","volume":"15","author":"Sun","year":"2014","journal-title":"Nat Rev Neurosci"},{"key":"2021080216411189700_ref56","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nn.4235","article-title":"Engineering microdeletions and microduplications by targeting segmental duplications with CRISPR","volume":"19","author":"Tai","year":"2016","journal-title":"Nat Neurosci"},{"key":"2021080216411189700_ref57","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1126\/science.aad0501","article-title":"Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq","volume":"352","author":"Tirosh","year":"2016","journal-title":"Science"},{"key":"2021080216411189700_ref58","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/j.1460-2075.1996.tb00378.x","article-title":"Kid, a novel kinesin-like DNA binding protein, is localized to chromosomes and the mitotic spindle","volume":"15","author":"Tokai","year":"1996","journal-title":"EMBO J"},{"key":"2021080216411189700_ref59","doi-asserted-by":"crossref","first-page":"5455","DOI":"10.1091\/mbc.e05-03-0244","article-title":"The chromokinesin kid is required for maintenance of proper metaphase spindle size","volume":"16","author":"Tokai-Nishizumi","year":"2005","journal-title":"Mol Biol Cell"},{"key":"2021080216411189700_ref60","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/nbt.2859","article-title":"The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells","volume":"32","author":"Trapnell","year":"2014","journal-title":"Nat Biotechnol"},{"key":"2021080216411189700_ref61","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.neuron.2014.10.025","article-title":"MST3 kinase phosphorylates TAO1\/2 to enable myosin Va function in promoting spine synapse development","volume":"84","author":"Ultanir","year":"2014","journal-title":"Neuron"},{"key":"2021080216411189700_ref62","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1056\/NEJMoa075974","article-title":"Association between microdeletion and microduplication at 16p11.2 and autism","volume":"358","author":"Weiss","year":"2008","journal-title":"N Engl J Med"},{"key":"2021080216411189700_ref63","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.neuron.2016.12.006","article-title":"TAOK2 kinase mediates PSD95 stability and dendritic spine maturation through Septin 7 phosphorylation","volume":"93","author":"Yadav","year":"2017","journal-title":"Neuron"},{"key":"2021080216411189700_ref64","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1093\/carcin\/bgu065","article-title":"Inhibition of KIF22 suppresses cancer cell proliferation by delaying mitotic exit through upregulating CDC25C expression","volume":"35","author":"Yu","year":"2014","journal-title":"Carcinogenesis"},{"key":"2021080216411189700_ref65","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/nature25980","article-title":"A single-cell RNA-seq survey of the developmental landscape of the human prefrontal cortex","volume":"555","author":"Zhong","year":"2018","journal-title":"Nature"},{"key":"2021080216411189700_ref66","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1136\/jmedgenet-2012-101203","article-title":"A 600 kb deletion syndrome at 16p11.2 leads to energy imbalance and neuropsychiatric disorders","volume":"49","author":"Zufferey","year":"2012","journal-title":"J Med Genet"}],"container-title":["Cerebral Cortex"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cercor\/article-pdf\/31\/9\/4038\/39377132\/bhab067.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/cercor\/article-pdf\/31\/9\/4038\/39377132\/bhab067.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T19:30:40Z","timestamp":1627932640000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cercor\/article\/31\/9\/4038\/6213405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,7]]},"references-count":66,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2021,4,7]]},"published-print":{"date-parts":[[2021,7,29]]}},"URL":"https:\/\/doi.org\/10.1093\/cercor\/bhab067","relation":{},"ISSN":["1047-3211","1460-2199"],"issn-type":[{"value":"1047-3211","type":"print"},{"value":"1460-2199","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,9]]},"published":{"date-parts":[[2021,4,7]]}}}