{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:35:56Z","timestamp":1772138156820,"version":"3.50.1"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T00:00:00Z","timestamp":1618790400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","award":["C14\/18\/100"],"award-info":[{"award-number":["C14\/18\/100"]}],"id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fonds voor Wetenschappelijk Onderzoek Vlaanderen","award":["G0A8516N"],"award-info":[{"award-number":["G0A8516N"]}]},{"name":"Fonds voor Wetenschappelijk Onderzoek Vlaanderen","award":["G.0007.12"],"award-info":[{"award-number":["G.0007.12"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Efficient object grasping requires the continuous control of arm and hand movements based on visual information. Previous studies have identified a network of parietal and frontal areas that is crucial for the visual control of prehension movements. Electrical microstimulation of 3D shape-selective clusters in AIP during functional magnetic resonance imaging activates areas F5a and 45B, suggesting that these frontal areas may represent important downstream areas for object processing during grasping, but the role of area F5a and 45B in grasping is unknown. To assess their causal role in the frontal grasping network, we reversibly inactivated 45B, F5a, and F5p during visually guided grasping in macaque monkeys. First, we recorded single neuron activity in 45B, F5a, and F5p to identify sites with object responses during grasping. Then, we injected muscimol or saline to measure the grasping deficit induced by the temporary disruption of each of these three nodes in the grasping network. The inactivation of all three areas resulted in a significant increase in the grasping time in both animals, with the strongest effect observed in area F5p. These results not only confirm a clear involvement of F5p, but also indicate causal contributions of area F5a and 45B in visually guided object grasping.<\/jats:p>","DOI":"10.1093\/cercor\/bhab085","type":"journal-article","created":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T11:34:32Z","timestamp":1618313672000},"page":"4274-4288","source":"Crossref","is-referenced-by-count":3,"title":["The Causal Role of Three Frontal Cortical Areas in Grasping"],"prefix":"10.1093","volume":"31","author":[{"given":"I","family":"Caprara","sequence":"first","affiliation":[{"name":"Laboratorium voor Neuro-en Psychofysiologie, Katholieke Universiteit Leuven, 3000 Leuven, Belgium"},{"name":"Division of Biology and Biological Engineering, Computation and Neural Systems, Caltech, Pasadena, CA 91125, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Janssen","sequence":"additional","affiliation":[{"name":"Laboratorium voor Neuro-en Psychofysiologie, Katholieke 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