{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:53:04Z","timestamp":1790646784050,"version":"4.1.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T00:00:00Z","timestamp":1618531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["268479"],"award-info":[{"award-number":["268479"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Eating habits leading to obesity may reflect nonhomeostatic behavior based on excessive immediate-reward seeking. However, it is currently unknown to what extent excess weight is associated with functional alterations in the brain\u2019s reward system in children. We tested the integrity of reward circuits using resting-state functional connectivity magnetic resonance imaging in a population of 230 children aged 8\u201312\u00a0years. The major components of the reward system were identified within the ventral striatum network defined on the basis of the nucleus accumbens connectivity pattern. The functional structure of the cerebral cortex was characterized using a combination of local functional connectivity measures. Higher body mass index was associated with weaker connectivity between the cortical and subcortical elements of the reward system, and enhanced the integration of the sensorimotor cortex to superior parietal areas relevant to body image formation. Obese children, unlike WHO-defined overweight condition, showed functional structure alterations in the orbitofrontal cortex and amygdala region similar to those previously observed in primary obsessive\u2013compulsive disorder and Prader\u2013Willi syndrome associated with obsessive eating behavior. Results further support the view that childhood obesity is not simply a deviant habit with restricted physical health consequences but is associated with reward system dysfunction characterizing behavioral control disorders.<\/jats:p>","DOI":"10.1093\/cercor\/bhab092","type":"journal-article","created":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T12:30:03Z","timestamp":1616675403000},"page":"4376-4385","source":"Crossref","is-referenced-by-count":20,"title":["Dysfunctional Brain Reward System in Child Obesity"],"prefix":"10.1093","volume":"31","author":[{"given":"Jesus","family":"Pujol","sequence":"first","affiliation":[{"name":"MRI Research Unit, Department of Radiology, Hospital del Mar, 08003 Barcelona, Spain"},{"name":"Centro Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental, CIBERSAM, 08003 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Blanco-Hinojo","sequence":"additional","affiliation":[{"name":"MRI Research Unit, Department of Radiology, Hospital del Mar, 08003 Barcelona, Spain"},{"name":"Centro Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental, CIBERSAM, 08003 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Mart\u00ednez-Vilavella","sequence":"additional","affiliation":[{"name":"MRI Research Unit, Department of Radiology, Hospital del Mar, 08003 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Deus","sequence":"additional","affiliation":[{"name":"MRI Research Unit, Department of Radiology, Hospital del Mar, 08003 Barcelona, Spain"},{"name":"Department of Clinical and Health Psychology, Autonomous University of Barcelona, 08193 Catalonia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00edctor","family":"P\u00e9rez-Sola","sequence":"additional","affiliation":[{"name":"Centro Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental, CIBERSAM, 08003 Barcelona, Spain"},{"name":"Institute of Neuropsychiatry and Addictions, Hospital del Mar\u2013IMIM, 08003 Barcelona, Spain"},{"name":"Department of Psychiatry, Autonomous University of Barcelona, 08193 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Sunyer","sequence":"additional","affiliation":[{"name":"ISGlobal, 08003 Barcelona, Spain"},{"name":"Pompeu Fabra University, 08002 Barcelona, Catalonia, Spain"},{"name":"Ciber on Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,4,16]]},"reference":[{"issue":"1","key":"2021080216505650300_ref1","first-page":"95","article-title":"A fast diffeomorphic image registration algorithm","volume":"38","author":"Ashburner","year":"2007","journal-title":"Neuro Image"},{"issue":"4","key":"2021080216505650300_ref2","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1017\/S0033291716002646","article-title":"Disrupted resting-state brain network properties in obesity: decreased global and putaminal cortico-striatal network efficiency","volume":"47","author":"Baek","year":"2017","journal-title":"Psychol Med"},{"issue":"Suppl 4","key":"2021080216505650300_ref3","doi-asserted-by":"crossref","first-page":"S164","DOI":"10.1542\/peds.2007-2329C","article-title":"Expert committee. 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