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In response, brain antioxidant levels may also increase with age, although this has not been well investigated. Here, we used edited magnetic resonance spectroscopy to quantify endogenous levels of glutathione (GSH, one of the most abundant brain antioxidants) in 37 young [mean: 21.8 (2.5) years; 19\u00a0female] and 23 older adults [mean: 72.8 (8.9) years; 19\u00a0female]. Accounting for age-related atrophy, we identified higher frontal and sensorimotor GSH levels for the older compared with the younger adults. For the older adults only, higher sensorimotor (but not frontal) GSH was correlated with poorer balance and gait. This suggests a regionally specific relationship between higher brain oxidative stress levels and motor performance declines with age. We suggest these findings reflect an upregulation of GSH in response to increasing brain oxidative stress with normal aging. Together, these results provide insight into age differences in brain antioxidant levels and implications for motor function.<\/jats:p>","DOI":"10.1093\/cercor\/bhab107","type":"journal-article","created":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T15:13:15Z","timestamp":1619709195000},"page":"4576-4594","source":"Crossref","is-referenced-by-count":41,"title":["In Vivo Brain Glutathione is Higher in Older Age and Correlates with Mobility"],"prefix":"10.1093","volume":"31","author":[{"given":"K E","family":"Hupfeld","sequence":"first","affiliation":[{"name":"Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32603, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H W","family":"Hyatt","sequence":"additional","affiliation":[{"name":"Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32603, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Alvarez Jerez","sequence":"additional","affiliation":[{"name":"Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32603, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Mikkelsen","sequence":"additional","affiliation":[{"name":"Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA"},{"name":"F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C J","family":"Hass","sequence":"additional","affiliation":[{"name":"Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32603, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R A E","family":"Edden","sequence":"additional","affiliation":[{"name":"Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA"},{"name":"F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R D","family":"Seidler","sequence":"additional","affiliation":[{"name":"Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32603, USA"},{"name":"Department of Neurology, University of Florida, Gainesville, FL 32611, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E C","family":"Porges","sequence":"additional","affiliation":[{"name":"Department of Clinical and Health Psychology, University of Florida, Gainesville, FL 32603, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,5,6]]},"reference":[{"issue":"6","key":"2021090106314544900_ref1","doi-asserted-by":"crossref","first-page":"635","DOI":"10.3109\/10715761003692529","article-title":"Specific oxidative stress profile associated with partial 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