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Executive function skills have been frequently observed to be decreased among children and adults with CHD compared with peers, but a neuroanatomical basis for the association is yet to be identified. In this study, we quantified sulcal pattern features from brain magnetic resonance imaging data obtained during adolescence among 41 participants with tetralogy of Fallot (ToF) and 49 control participants using a graph-based pattern analysis technique. Among patients with ToF, right-hemispheric sulcal pattern similarity to the control group was decreased (0.7514 vs. 0.7553, P\u2009=\u20090.01) and positively correlated with neuropsychological testing values including executive function (r\u2009=\u20090.48, P\u2009&amp;lt;\u20090.001). Together these findings suggest that sulcal pattern analysis may be a useful marker of neurodevelopmental risk in patients with CHD. Further studies may elucidate the mechanisms leading to different alterations in sulcal patterning.<\/jats:p>","DOI":"10.1093\/cercor\/bhab114","type":"journal-article","created":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T16:04:18Z","timestamp":1618416258000},"page":"4670-4680","source":"Crossref","is-referenced-by-count":16,"title":["Abnormal Right-Hemispheric Sulcal Patterns Correlate with Executive Function in Adolescents with Tetralogy of Fallot"],"prefix":"10.1093","volume":"31","author":[{"given":"Sarah U","family":"Morton","sequence":"first","affiliation":[{"name":"Division of Newborn Medicine , , Boston, MA 02115,","place":["USA"]},{"name":"Boston Children\u2019s Hospital , , Boston, MA 02115,","place":["USA"]},{"name":"Department of Pediatrics , , Boston, MA 02115,","place":["USA"]},{"name":"Harvard Medical School , , Boston, MA 02115,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Maleyeff","sequence":"additional","affiliation":[{"name":"Department of Biostatistics , , Boston, MA 02115,","place":["USA"]},{"name":"Harvard T.H. Chan School of Public Health , , Boston, MA 02115,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Wypij","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , , Boston, MA 02115,","place":["USA"]},{"name":"Harvard Medical School , , Boston, MA 02115,","place":["USA"]},{"name":"Department of Biostatistics , , Boston, MA 02115,","place":["USA"]},{"name":"Harvard T.H. Chan School of Public Health , , Boston, MA 02115,","place":["USA"]},{"name":"Department of Cardiology , , Boston, MA 02115,","place":["USA"]},{"name":"Boston Children\u2019s Hospital , , Boston, MA 02115,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyuk Jin","family":"Yun","sequence":"additional","affiliation":[{"name":"Division of Newborn Medicine , , Boston, MA 02115,","place":["USA"]},{"name":"Boston Children\u2019s Hospital , , Boston, MA 02115,","place":["USA"]},{"name":"Fetal Neonatal Neuroimaging and Developmental Science Center , , Boston, MA 02115,","place":["USA"]},{"name":"Boston Children\u2019s Hospital , , Boston, MA 02115,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin K","family":"Rollins","sequence":"additional","affiliation":[{"name":"Department of Neurology , , Boston, MA 02115,","place":["USA"]},{"name":"Boston Children\u2019s Hospital , , Boston, MA 02115,","place":["USA"]},{"name":"Department of Neurology , , Boston, MA 02115,","place":["USA"]},{"name":"Harvard Medical School , , Boston, MA 02115,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher G","family":"Watson","sequence":"additional","affiliation":[{"name":"Department of Neurology , , Boston, MA 02115,","place":["USA"]},{"name":"Boston Children\u2019s Hospital , , Boston, MA 02115,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane W","family":"Newburger","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , , Boston, MA 02115,","place":["USA"]},{"name":"Harvard Medical School , , Boston, MA 02115,","place":["USA"]},{"name":"Department of Cardiology , , Boston, MA 02115,","place":["USA"]},{"name":"Boston Children\u2019s Hospital , , Boston, MA 02115,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C","family":"Bellinger","sequence":"additional","affiliation":[{"name":"Department of Neurology , , Boston, MA 02115,","place":["USA"]},{"name":"Boston Children\u2019s Hospital , , Boston, MA 02115,","place":["USA"]},{"name":"Department of Neurology , , Boston, MA 02115,","place":["USA"]},{"name":"Harvard Medical School , , Boston, MA 02115,","place":["USA"]},{"name":"Department of Psychiatry , , Boston, MA 02115,","place":["USA"]},{"name":"Boston Children\u2019s Hospital , , Boston, MA 02115,","place":["USA"]},{"name":"Department of Psychiatry , , Boston, MA 02115,","place":["USA"]},{"name":"Harvard Medical School , , Boston, MA 02115,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy E","family":"Roberts","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , , Boston, MA 02115,","place":["USA"]},{"name":"Harvard Medical School , , Boston, MA 02115,","place":["USA"]},{"name":"Department of Cardiology , , Boston, MA 02115,","place":["USA"]},{"name":"Boston Children\u2019s Hospital , , Boston, MA 02115,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J","family":"Rivkin","sequence":"additional","affiliation":[{"name":"Department of Neurology , , Boston, MA 02115,","place":["USA"]},{"name":"Boston Children\u2019s Hospital , , Boston, MA 02115,","place":["USA"]},{"name":"Department of Neurology , , Boston, MA 02115,","place":["USA"]},{"name":"Harvard Medical School , , Boston, MA 02115,","place":["USA"]},{"name":"Department of Psychiatry , , Boston, MA 02115,","place":["USA"]},{"name":"Boston Children\u2019s Hospital , , Boston, MA 02115,","place":["USA"]},{"name":"Division of Radiology , , Boston, MA 02115,","place":["USA"]},{"name":"Boston Children\u2019s Hospital , , Boston, MA 02115,","place":["USA"]},{"name":"Stroke and Cerebrovascular Center , , Boston, MA 02115,","place":["USA"]},{"name":"Boston Children\u2019s Hospital , , Boston, MA 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