{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T15:58:38Z","timestamp":1781020718755,"version":"3.54.1"},"reference-count":64,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T00:00:00Z","timestamp":1620950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2016YFC1307000"],"award-info":[{"award-number":["2016YFC1307000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2016YFC1307201"],"award-info":[{"award-number":["2016YFC1307201"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771443"],"award-info":[{"award-number":["81771443"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81825009"],"award-info":[{"award-number":["81825009"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31771186"],"award-info":[{"award-number":["31771186"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81361120395"],"award-info":[{"award-number":["81361120395"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82022035"],"award-info":[{"award-number":["82022035"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61773380"],"award-info":[{"award-number":["61773380"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001450"],"award-info":[{"award-number":["82001450"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Peking University Clinical Scientist Program","award":["BMU2019LCKXJ012"],"award-info":[{"award-number":["BMU2019LCKXJ012"]}]},{"name":"Chinese Institute for Brain Research at Beijing","award":["2020-NKX-XM-12"],"award-info":[{"award-number":["2020-NKX-XM-12"]}]},{"DOI":"10.13039\/501100002858","name":"Postdoctoral Science Foundation","doi-asserted-by":"crossref","award":["BX20200364"],"award-info":[{"award-number":["BX20200364"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Urbanicity has been suggested to affect cognition, but the underlying mechanism remains unknown. We examined whether epigenetic modification (DNA methylation, DNAm), and brain white matter fiber integrity (fractional anisotropy, FA) or local spontaneous brain function activity (regional homogeneity, ReHo) play roles in the association between childhood urbanicity and cognition based on 497 healthy Chinese adults. We found significant correlation between childhood urbanicity and better cognitive performance. Multiset canonical correlation analysis (mCCA) identified an intercorrelated DNAm-FA-ReHo triplet, which showed significant pairwise correlations (DNAm-FA: Bonferroni-adjusted P, Pbon\u2009=\u20094.99E\u221203, rho\u2009=\u20090.216; DNAm-ReHo: Pbon\u2009=\u20094.08E\u221203, rho\u2009=\u20090.239; ReHo-FA: Pbon\u2009=\u20091.68E\u221206, rho\u2009=\u20090.328). Causal mediation analysis revealed that 1) ReHo mediated 10.86% childhood urbanicity effects on the speed of processing and 2) childhood urbanicity alters ReHo through DNA methylation in the cadherin and Wnt signaling pathways (mediated effect: 48.55%). The mediation effect of increased ReHo in the superior temporal gyrus underlying urbanicity impact on a better speed of processing was further validated in an independent cohort. Our work suggests a mediation role for ReHo, particularly increased brain activity in the superior temporal gyrus, in the urbanicity-associated speed of processing.<\/jats:p>","DOI":"10.1093\/cercor\/bhab117","type":"journal-article","created":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T19:06:57Z","timestamp":1618600017000},"page":"4709-4718","source":"Crossref","is-referenced-by-count":10,"title":["DNA Methylation and Resting Brain Function Mediate the Association between Childhood Urbanicity and Better Speed of Processing"],"prefix":"10.1093","volume":"31","author":[{"given":"Weiqiu","family":"Cheng","sequence":"first","affiliation":[{"name":"Peking University Sixth Hospital\/Institute of Mental Health, Beijing 100191, China"},{"name":"NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Luo","sequence":"additional","affiliation":[{"name":"Brainnetome Center and National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyanan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Peking University Sixth Hospital\/Institute of Mental Health, Beijing 100191, China"},{"name":"NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Peking University Sixth Hospital\/Institute of Mental Health, Beijing 100191, China"},{"name":"NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyang","family":"Tan","sequence":"additional","affiliation":[{"name":"Lieber Institute for Brain Development, Baltimore, MD 21205, USA"},{"name":"Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Peking University Sixth Hospital\/Institute of Mental Health, Beijing 100191, China"},{"name":"NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing 100191, China"},{"name":"Tsinghua University-Peking University Joint Center for Life Sciences, Beijing 100871, China"},{"name":"PKU-IDG\/McGovern Institute for Brain Research, Peking University, Beijing 100871, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Sui","sequence":"additional","affiliation":[{"name":"University of Chinese Academy of Sciences, Beijing 100049, China"},{"name":"State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Yue","sequence":"additional","affiliation":[{"name":"Peking University Sixth Hospital\/Institute of Mental Health, Beijing 100191, China"},{"name":"NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing 100191, China"},{"name":"PKU-IDG\/McGovern Institute for Brain Research, Peking University, Beijing 100871, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Yan","sequence":"additional","affiliation":[{"name":"Peking University Sixth Hospital\/Institute of Mental Health, Beijing 100191, China"},{"name":"NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,5,14]]},"reference":[{"key":"2021090106411142300_ref1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1006\/jmrb.1996.0086","article-title":"Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI","volume":"111","author":"Basser","year":"1996","journal-title":"J Magn Reson B"},{"key":"2021090106411142300_ref2","doi-asserted-by":"crossref","DOI":"10.1111\/desc.12579","article-title":"Differences in brain morphology and working memory capacity across childhood","volume":"21","author":"Bathelt","year":"2018","journal-title":"Dev Sci"},{"key":"2021090106411142300_ref3","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1080\/87565640701190841","article-title":"Superior temporal gyrus, language function, and autism","volume":"31","author":"Bigler","year":"2007","journal-title":"Dev Neuropsychol"},{"key":"2021090106411142300_ref4","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41398-019-0376-y","article-title":"Genome-wide DNA methylation comparison between live human brain and peripheral tissues within individuals","volume":"9","author":"Braun","year":"2019","journal-title":"Transl Psychiatry"},{"key":"2021090106411142300_ref5","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.neuroscience.2009.03.081","article-title":"Brain-derived neurotrophic factor as a model system for examining gene by environment interactions across development","volume":"164","author":"Casey","year":"2009","journal-title":"Neuroscience"},{"key":"2021090106411142300_ref6","first-page":"193","article-title":"Cognitive diagnosis of mathematics performance between rural and urban students in Taiwan","volume":"19","author":"Chen","year":"2012","journal-title":"Assess Educ Princ Pol Pract"},{"key":"2021090106411142300_ref7","doi-asserted-by":"crossref","DOI":"10.4324\/9780203771587","volume-title":"Statistical power analysis for the behavioral sciences","author":"Cohen","year":"2013"},{"key":"2021090106411142300_ref8","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.neuroscience.2013.12.044","article-title":"The early development of brain white matter: a review of imaging studies in fetuses, newborns and infants","volume":"276","author":"Dubois","year":"2014","journal-title":"Neuroscience"},{"key":"2021090106411142300_ref9","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1126\/science.1150198","article-title":"Health and urban living","volume":"319","author":"Dye","year":"2008","journal-title":"Science"},{"key":"2021090106411142300_ref10","doi-asserted-by":"crossref","first-page":"e1187","DOI":"10.1038\/tp.2017.171","article-title":"BECon: a tool for interpreting DNA methylation findings from blood in the context of brain","volume":"7","author":"Edgar","year":"2017","journal-title":"Transl Psychiatry"},{"key":"2021090106411142300_ref11","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1523\/JNEUROSCI.21-03-00788.2001","article-title":"DNA hypomethylation perturbs the function and survival of CNS neurons in postnatal animals","volume":"21","author":"Fan","year":"2001","journal-title":"J Neurosci"},{"key":"2021090106411142300_ref12","doi-asserted-by":"crossref","first-page":"3345","DOI":"10.1242\/dev.01912","article-title":"DNA methylation controls the timing of astrogliogenesis through regulation of JAK-STAT signaling","volume":"132","author":"Fan","year":"2005","journal-title":"Development"},{"key":"2021090106411142300_ref13","first-page":"S277","article-title":"A haplotype of the norepinephrine transporter gene modulates intrinsic brain activity, visual memory, and visual attention in children with attention-deficit\/hyperactivity disorder","volume":"43","author":"Gau","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"2021090106411142300_ref14","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1017\/S1355617709090535","article-title":"Examination of processing speed deficits in multiple sclerosis using functional magnetic resonance imaging","volume":"15","author":"Genova","year":"2009","journal-title":"J Int Neuropsychol Soc"},{"key":"2021090106411142300_ref15","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/nrn.2018.1","article-title":"Imaging structural and functional brain development in early childhood","volume":"19","author":"Gilmore","year":"2018","journal-title":"Nat Rev Neurosci"},{"key":"2021090106411142300_ref16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ajhb.20590","article-title":"Early life events and their consequences for later disease: a life history and evolutionary perspective","volume":"19","author":"Gluckman","year":"2007","journal-title":"Am J Hum Biol"},{"key":"2021090106411142300_ref17","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1037\/0894-4105.14.3.353","article-title":"A comparison of rCBF patterns during letter and semantic fluency","volume":"14","author":"Gourovitch","year":"2000","journal-title":"Neuropsychology"},{"key":"2021090106411142300_ref18","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1017\/S1355617710001384","article-title":"Neuropsychological performance in mainland China: the effect of urban\/rural residence and self-reported daily academic skill use","volume":"17","author":"Gupta","year":"2011","journal-title":"J Int Neuropsychol Soc"},{"key":"2021090106411142300_ref19","doi-asserted-by":"crossref","first-page":"2796","DOI":"10.1093\/cercor\/bht135","article-title":"Altered microstructure within social-cognitive brain networks during childhood in Williams syndrome","volume":"24","author":"Haas","year":"2014","journal-title":"Cereb Cortex"},{"key":"2021090106411142300_ref20","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1093\/schbul\/sbu072","article-title":"Brain structure correlates of urban upbringing, an environmental risk factor for schizophrenia","volume":"41","author":"Haddad","year":"2015","journal-title":"Schizophr Bull"},{"key":"2021090106411142300_ref21","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/nn.4194","article-title":"DNA methylation changes in plasticity genes accompany the formation and maintenance of memory","volume":"19","author":"Halder","year":"2016","journal-title":"Nat Neurosci"},{"key":"2021090106411142300_ref22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1007544","article-title":"Characterizing genetic and environmental influences on variable DNA methylation using monozygotic and dizygotic twins","volume":"14","author":"Hannon","year":"2018","journal-title":"PLoS Genet"},{"key":"2021090106411142300_ref23","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1080\/15592294.2015.1100786","article-title":"Interindividual methylomic variation across blood, cortex, and cerebellum: implications for epigenetic studies of neurological and neuropsychiatric phenotypes","volume":"10","author":"Hannon","year":"2015","journal-title":"Epigenetics"},{"key":"2021090106411142300_ref24","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-12921-z","article-title":"Tau deposition is associated with functional isolation of the hippocampus in aging","volume":"10","author":"Harrison","year":"2019","journal-title":"Nat Commun"},{"key":"2021090106411142300_ref25","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1038\/mp.2009.55","article-title":"The heritability of general cognitive ability increases linearly from childhood to young adulthood","volume":"15","author":"Haworth","year":"2010","journal-title":"Mol Psychiatry"},{"key":"2021090106411142300_ref26","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2202-13-98","article-title":"Neural mechanisms underlying the facilitation of naming in aphasia using a semantic task: an fMRI study","volume":"13","author":"Heath","year":"2012","journal-title":"BMC Neurosci"},{"key":"2021090106411142300_ref27","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1152\/physrev.00014.2011","article-title":"Cadherins in brain morphogenesis and wiring","volume":"92","author":"Hirano","year":"2012","journal-title":"Physiol Rev"},{"key":"2021090106411142300_ref28","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0304-3940(01)02566-6","article-title":"Lateralized organization of the cerebellum in a silent verbal fluency task: a functional magnetic resonance imaging study in healthy volunteers","volume":"319","author":"Hubrich-Ungureanu","year":"2002","journal-title":"Neurosci Lett"},{"key":"2021090106411142300_ref29","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1037\/0735-7044.103.3.548","article-title":"Cognitive impairment following frontal lobe damage and its relevance to human amnesia","volume":"103","author":"Janowsky","year":"1989","journal-title":"Behav Neurosci"},{"key":"2021090106411142300_ref30","doi-asserted-by":"crossref","first-page":"433\u2013451","DOI":"10.1093\/biomet\/58.3.433","article-title":"Canonical analysis of several sets of variables","volume":"58","author":"Kettenring","year":"1971","journal-title":"Biometrika"},{"key":"2021090106411142300_ref31","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1162\/0898929042304796","article-title":"Sensitive periods in the development of the brain and behavior","volume":"16","author":"Knudsen","year":"2004","journal-title":"J Cogn Neurosci"},{"key":"2021090106411142300_ref32","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/nature10190","article-title":"City living and urban upbringing affect neural social stress processing in humans","volume":"474","author":"Lederbogen","year":"2011","journal-title":"Nature"},{"key":"2021090106411142300_ref33","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1002\/hbm.20359","article-title":"Estimating the number of independent components for functional magnetic resonance imaging data","volume":"28","author":"Li","year":"2007","journal-title":"Hum Brain Mapp"},{"key":"2021090106411142300_ref34","doi-asserted-by":"crossref","first-page":"3918","DOI":"10.1109\/TSP.2009.2021636","article-title":"Joint blind source separation by multi-set canonical correlation analysis","volume":"57","author":"Li","year":"2009","journal-title":"IEEE Trans Signal Process"},{"key":"2021090106411142300_ref35","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1037\/a0031139","article-title":"Urbanization decreases attentional engagement","volume":"39","author":"Linnell","year":"2013","journal-title":"J Exp Psychol Hum Percept Perform"},{"key":"2021090106411142300_ref36","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1093\/schbul\/sby045","article-title":"Linked 4-way multimodal brain differences in schizophrenia in a large Chinese Han population","volume":"45","author":"Liu","year":"2019","journal-title":"Schizophr Bull"},{"key":"2021090106411142300_ref37","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1006\/nimg.2000.0743","article-title":"Maturation of widely distributed brain function subserves cognitive development","volume":"13","author":"Luna","year":"2001","journal-title":"NeuroImage"},{"key":"2021090106411142300_ref38","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.ebiom.2018.10.009","article-title":"A schizophrenia-related genetic-brain-cognition pathway revealed in a large Chinese population","volume":"37","author":"Luo","year":"2018","journal-title":"EBioMedicine"},{"key":"2021090106411142300_ref39","doi-asserted-by":"crossref","DOI":"10.1016\/j.psychres.2019.112603","article-title":"Decreased regional homogeneity and increased functional connectivity of default network correlated with neurocognitive deficits in subjects with genetic high-risk for schizophrenia: a resting-state fMRI study","volume":"281","author":"Ma","year":"2019","journal-title":"Psychiatry Res"},{"key":"2021090106411142300_ref40","doi-asserted-by":"crossref","first-page":"13057","DOI":"10.1523\/JNEUROSCI.3248-11.2011","article-title":"Wnt signaling in amygdala-dependent learning and memory","volume":"31","author":"Maguschak","year":"2011","journal-title":"J Neurosci"},{"key":"2021090106411142300_ref41","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1098\/rspb.2000.1229","article-title":"Differential effects of word length and visual contrast in the fusiform and lingual gyri during reading","volume":"267","author":"Mechelli","year":"2000","journal-title":"Proc Roy Soc B-Biol Sci"},{"key":"2021090106411142300_ref42","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.biopsych.2020.08.014","article-title":"Multivariate patterns of brain-behavior-environment associations in the adolescent brain and cognitive development study","volume":"89","author":"Modabbernia","year":"2021","journal-title":"Biol Psychiatry"},{"key":"2021090106411142300_ref43","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1093\/schbul\/sbu123","article-title":"Comparing fractional anisotropy in patients with childhood-onset schizophrenia, their healthy siblings, and normal volunteers through DTI","volume":"41","author":"Moran","year":"2015","journal-title":"Schizophr Bull"},{"key":"2021090106411142300_ref44","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1056\/NEJM199902253400803","article-title":"Effects of family history and place and season of birth on the risk of schizophrenia","volume":"340","author":"Mortensen","year":"1999","journal-title":"N Engl J Med"},{"key":"2021090106411142300_ref45","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1098\/rspb.1996.0146","article-title":"Generating \u2018tiger\u2019 as an animal name or a word beginning with T: differences in brain activation","volume":"263","author":"Mummery","year":"1996","journal-title":"Proc Biol Sci"},{"key":"2021090106411142300_ref46","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1176\/appi.ajp.2007.07010042","article-title":"The MATRICS Consensus Cognitive Battery, part 1: test selection, reliability, and validity","volume":"165","author":"Nuechterlein","year":"2008","journal-title":"Am J Psychiatry"},{"key":"2021090106411142300_ref47","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.biopsych.2016.03.2100","article-title":"DNA methylation signatures of early childhood malnutrition associated with impairments in attention and cognition","volume":"80","author":"Peter","year":"2016","journal-title":"Biol Psychiatry"},{"key":"2021090106411142300_ref48","volume-title":"Emotional intelligence","author":"Peter","year":"2010"},{"key":"2021090106411142300_ref49","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/mp.2014.105","article-title":"Genetics and intelligence differences: five special findings","volume":"20","author":"Plomin","year":"2015","journal-title":"Mol Psychiatry"},{"key":"2021090106411142300_ref50","first-page":"213","article-title":"Cognitive control network homogeneity and executive functions in late-life depression","volume":"5","author":"Respino","year":"2020","journal-title":"Biol Psychiatry Cogn Neurosci Neuroimaging"},{"key":"2021090106411142300_ref51","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/j.1469-7610.2010.02282.x","article-title":"Annual research review: epigenetic mechanisms and environmental shaping of the brain during sensitive periods of development","volume":"52","author":"Roth","year":"2011","journal-title":"J Child Psychol Psychiatry"},{"key":"2021090106411142300_ref51a","article-title":"The MATRICS Consensus Cognitive Battery (MCCB): Co-norming and standardization in China","volume":"169","author":"","year":"2015","journal-title":"Schizophr Res"},{"key":"2021090106411142300_ref52","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.neuroimage.2012.10.051","article-title":"Three-way (N-way) fusion of brain imaging data based on mCCA+jICA and its application to discriminating schizophrenia","volume":"66","author":"Sui","year":"2013","journal-title":"NeuroImage"},{"key":"2021090106411142300_ref53","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.biopsych.2015.02.017","article-title":"In search of multimodal neuroimaging biomarkers of cognitive deficits in schizophrenia","volume":"78","author":"Sui","year":"2015","journal-title":"Biol Psychiatry"},{"key":"2021090106411142300_ref54","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1017\/S0954579419000580","article-title":"Pubertal development mediates the association between family environment and brain structure and function in childhood","volume":"32","author":"Thijssen","year":"2020","journal-title":"Dev Psychopathol"},{"key":"2021090106411142300_ref55","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1080\/15248372.2013.797906","article-title":"Working memory differences between children living in rural and urban poverty","volume":"15","author":"Tine","year":"2014","journal-title":"J Cogn Dev"},{"key":"2021090106411142300_ref56","article-title":"Mediation: R package for causal mediation analysis","volume-title":"J Stat Softw.","author":"Tingley","year":"2014"},{"key":"2021090106411142300_ref57","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1038\/nn.4108","article-title":"Environmental influence in the brain, human welfare and mental health","volume":"18","author":"Tost","year":"2015","journal-title":"Nat Neurosci"},{"key":"2021090106411142300_ref58","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.biopsych.2014.11.022","article-title":"Effects of the social environment and stress on glucocorticoid receptor gene methylation: a systematic review","volume":"79","author":"Turecki","year":"2016","journal-title":"Biol Psychiatry"},{"key":"2021090106411142300_ref59","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1093\/jurban\/79.suppl_1.S1","article-title":"Urbanization, urbanicity, and health","volume":"79","author":"Vlahov","year":"2002","journal-title":"J Urban Health"},{"key":"2021090106411142300_ref60","doi-asserted-by":"crossref","first-page":"W130","DOI":"10.1093\/nar\/gkx356","article-title":"Web Gestalt 2017: a more comprehensive, powerful, flexible and interactive gene set enrichment analysis toolkit","volume":"45","author":"Wang","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"2021090106411142300_ref61","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1038\/s41467-017-01261-5","article-title":"Functional mapping and annotation of genetic associations with FUMA","volume":"8","author":"Watanabe","year":"2017","journal-title":"Nat Commun"},{"key":"2021090106411142300_ref62","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.neubiorev.2020.03.007","article-title":"DNA methylation and brain structure and function across the life course: a systematic review","volume":"113","author":"Wheater","year":"2020","journal-title":"Neurosci Biobehav Rev"},{"key":"2021090106411142300_ref63","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.neuroimage.2003.12.030","article-title":"Regional homogeneity approach to fMRI data analysis","volume":"22","author":"Zang","year":"2004","journal-title":"NeuroImage"}],"container-title":["Cerebral Cortex"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/cercor\/article-pdf\/31\/10\/4709\/39955847\/bhab117.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/cercor\/article-pdf\/31\/10\/4709\/39955847\/bhab117.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T06:45:30Z","timestamp":1630478730000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cercor\/article\/31\/10\/4709\/6275467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,14]]},"references-count":64,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2021,5,14]]},"published-print":{"date-parts":[[2021,8,26]]}},"URL":"https:\/\/doi.org\/10.1093\/cercor\/bhab117","relation":{},"ISSN":["1047-3211","1460-2199"],"issn-type":[{"value":"1047-3211","type":"print"},{"value":"1460-2199","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,10]]},"published":{"date-parts":[[2021,5,14]]}}}