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We analyzed data from two independent datasets, including 166 participants (103\u00a0AD\/63 controls) from the DZNE-longitudinal cognitive impairment and dementia study and 151 participants (121\u00a0AD\/30 controls) from the AD neuroimaging initiative cohorts, aiming to identify differences between AD atrophy subtypes in resting-state functional magnetic resonance imaging intra-network connectivity (INC) and global and nodal network properties. Using a data-driven clustering approach, we identified four AD atrophy subtypes with differences in functional connectivity, accompanied by clinical and biomarker alterations, including a medio-temporal-predominant (S-MT), a limbic-predominant (S-L), a diffuse (S-D), and a mild-atrophy (S-MA) subtype. S-MT and S-D showed INC reduction in the default mode, dorsal attention, visual and limbic network, and a pronounced reduction of \u201cglobal efficiency\u201d and decrease of the \u201cclustering coefficient\u201d in parietal and temporal lobes. Despite severe atrophy in limbic areas, the S-L exhibited only marginal global network but substantial nodal network failure. S-MA, in contrast, showed limited impairment in clinical and cognitive scores but pronounced global network failure. Our results contribute toward a better understanding of heterogeneity in AD with the detection of distinct differences in functional connectivity networks accompanied by CSF biomarker and cognitive differences in AD subtypes.<\/jats:p>","DOI":"10.1093\/cercor\/bhab130","type":"journal-article","created":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T15:17:03Z","timestamp":1621523823000},"page":"4901-4915","source":"Crossref","is-referenced-by-count":21,"title":["Resting-State Network Alterations Differ between Alzheimer\u2019s Disease Atrophy Subtypes"],"prefix":"10.1093","volume":"31","author":[{"given":"Boris-Stephan","family":"Rauchmann","sequence":"first","affiliation":[{"name":"Department of Radiology, University Hospital, LMU, Munich 81377, Germany"},{"name":"Department of Psychiatry and Psychotherapy, University Hospital, LMU, Munich 80336, 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