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Here, we report abnormal developmental dynamics of brain white matter (WM) microstructures and network topological organizations via diffusion tensor imaging. Specifically, disrupted WM microstructural integrity was observed at 9\u00a0months, but recovered thereafter, whereas WM network topological properties showed persistent abnormal dynamics from 9 to 37\u00a0months. Changes in the WM microstructure and WM network topology were correlated well with RTT-associated behavioral abnormalities including sleep latency, environmental exploration, and conflict encounters. Deleterious and protracted early WM myelination process likely lead to abnormal synaptic pruning, resulting in poor functional segregations. Together, this study provides initial evidence for changes in WM microstructure and network topological organization, which may underlie the neuro-patho-etilogy of RTT.<\/jats:p>","DOI":"10.1093\/cercor\/bhab166","type":"journal-article","created":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T19:12:04Z","timestamp":1621883524000},"page":"5396-5410","source":"Crossref","is-referenced-by-count":18,"title":["White Matter Structural and Network Topological Changes Underlying the Behavioral Phenotype of <i>MECP2<\/i> Mutant Monkeys"],"prefix":"10.1093","volume":"31","author":[{"given":"Jiaojian","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory for NeuroInformation of the Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengbo","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key 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650500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming 650500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming 650500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi Eve","family":"Sun","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Stem Cell Research and Clinical Translation, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, 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