{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T03:06:01Z","timestamp":1781924761580,"version":"3.54.5"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T00:00:00Z","timestamp":1624492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81700088"],"award-info":[{"award-number":["81700088"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070091"],"award-info":[{"award-number":["82070091"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"International Cooperation and Exchange of the National Natural Science Foundation of China","award":["82020108001"],"award-info":[{"award-number":["82020108001"]}]},{"DOI":"10.13039\/100010097","name":"China Association for Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010097","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Morphological changes in the cortex of narcolepsy patients were investigated by surface-based morphometry analysis in this study. Fifty-one type 1 narcolepsy patients and 60 demographically group-matched healthy controls provided resting-state functional and high-resolution 3T anatomical magnetic resonance imaging scans. Vertex-level cortical thickness (CT), gyrification, and voxel-wise functional connectivity were calculated. Adolescent narcolepsy patients showed decreased CT in bilateral frontal cortex and left precuneus. Adolescent narcolepsy demonstrated increased gyrification in left occipital lobe, left precuneus, and right fusiform but decreased gyrification in left postcentral gyrus, whereas adult narcolepsy exhibited increased gyrification in left temporal lobe and right frontal cortex. Furthermore, sleepiness severity was associated with altered CT and gyrification. Increased gyrification was associated with reduced long-range functional connectivity. In adolescent patients, those with more severe sleepiness showed increased right postcentral gyrification. Decreased frontal and occipital gyrification was found in cases with hallucination. In adult patients, a wide range of regions showed reduced gyrification in those with adolescence-onset compared adult-onset narcolepsy patients. Particularly the frontal lobes showed altered brain morphology, being a thinner cortex and more gyri. The impact of narcolepsy on age-related brain morphological changes may remain from adolescence to young adulthood, and it was especially exacerbated in adolescence.<\/jats:p>","DOI":"10.1093\/cercor\/bhab171","type":"journal-article","created":{"date-parts":[[2021,5,29]],"date-time":"2021-05-29T13:37:04Z","timestamp":1622295424000},"page":"5460-5469","source":"Crossref","is-referenced-by-count":7,"title":["Morphological and Age-Related Changes in the Narcolepsy Brain"],"prefix":"10.1093","volume":"31","author":[{"given":"Xiao","family":"Fulong","sequence":"first","affiliation":[{"name":"Department of General Internal Medicine, Peking University People\u2019s Hospital, Beijing 100044, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Spruyt","sequence":"additional","affiliation":[{"name":"Lyon Neuroscience Research Center, INSERM, U1028-CNRS UMR 5292, School of Medicine, University Claude Bernard, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Xiaosong","sequence":"additional","affiliation":[{"name":"Sleep Medicine Center, Department of Respiratory and Critical Care Medicine, Peking University People\u2019s Hospital, Beijing 100044, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cao","family":"Zhaolong","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine, Peking University People\u2019s Hospital, Beijing 100044, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Jun","sequence":"additional","affiliation":[{"name":"Department of Neurology, Peking University People\u2019s Hospital, Beijing 100044, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Fang","sequence":"additional","affiliation":[{"name":"Sleep Medicine Center, Department 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