{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:39:37Z","timestamp":1790710777346,"version":"4.1.0"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T00:00:00Z","timestamp":1634601600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971202"],"award-info":[{"award-number":["81971202"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81790653"],"award-info":[{"award-number":["81790653"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671367"],"award-info":[{"award-number":["81671367"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We aim to explore the microscopic neurophysiology of focal cortical dysplasia (FCD) induced epileptogenesis in specific macroscopic brain regions, therefore mapping a micro\u2013macro neuronal network that potentially indicates the epileptogenic mechanism. Epileptic and relatively non-epileptic temporal neocortex specimens were resected from FCD and mesial temporal lobe epilepsy (mTLE) patients, respectively. Whole-cell patch-clamping was performed on cells from the seizure onset zone (SOZ) and non-SOZ inside the epileptogenic zone (EZ) of FCD patients, as well as the non-epileptic neocortex of mTLE patients. Microscopic data were recorded, including membrane characteristics, spontaneous synaptic activities, and evoked action potentials. Immunohistochemistry was also performed on parvalbumin-positive (PV+) interneurons. We found that SOZ interneurons exhibited abnormal neuronal expression and distribution as well as reduced overall function compared with non-SOZ and mTLE interneurons. The SOZ pyramidal cells experienced higher excitation but lower inhibition than the mTLE controls, whereas the non-SOZ pyramidal cells exhibited intermediate excitability. Action potential properties of both types of neurons also suggested more synchronized neuronal activity inside the EZ, particularly inside the SOZ. Together, our research provides evidence for a potential neurocircuit underlying SOZ epileptogenesis and non-SOZ seizure susceptibility. Further investigation of this microscopic network may promote understanding of the mechanism of FCD-induced epileptogenesis.<\/jats:p>","DOI":"10.1093\/cercor\/bhab350","type":"journal-article","created":{"date-parts":[[2021,10,16]],"date-time":"2021-10-16T00:09:54Z","timestamp":1634342994000},"page":"2216-2230","source":"Crossref","is-referenced-by-count":18,"title":["Mechanistic Analysis of Micro-Neurocircuits Underlying the Epileptogenic Zone in Focal Cortical Dysplasia Patients"],"prefix":"10.1093","volume":"32","author":[{"given":"Lipeng","family":"Cheng","sequence":"first","affiliation":[{"name":"Center of Epilepsy, Beijing Institute of Brain Disorders, Capital Medical University, Beijing 100069, China"},{"name":"Fundamental Research Department, Guangzhou Laboratory, Guangzhou 510700, China"},{"name":"Neuroelectrophysiological Laboratory, Xuanwu Hospital, Capital Medical University, Beijing 100053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Xing","sequence":"additional","affiliation":[{"name":"Center of Epilepsy, Beijing Institute of Brain Disorders, Capital Medical University, Beijing 100069, China"},{"name":"Fundamental Research Department, Guangzhou Laboratory, Guangzhou 510700, China"},{"name":"Neuroelectrophysiological Laboratory, Xuanwu Hospital, Capital Medical University, Beijing 100053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Fundamental Research Department, Guangzhou Laboratory, Guangzhou 510700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru","family":"Liu","sequence":"additional","affiliation":[{"name":"Center of Epilepsy, Beijing Institute of Brain Disorders, Capital Medical University, Beijing 100069, China"},{"name":"Fundamental Research Department, Guangzhou Laboratory, Guangzhou 510700, 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Beijing 100053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaonan","family":"Li","sequence":"additional","affiliation":[{"name":"Center of Epilepsy, Beijing Institute of Brain Disorders, Capital Medical University, Beijing 100069, China"},{"name":"Fundamental Research Department, Guangzhou Laboratory, Guangzhou 510700, China"},{"name":"Neuroelectrophysiological Laboratory, Xuanwu Hospital, Capital Medical University, Beijing 100053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaoyang","family":"Wang","sequence":"additional","affiliation":[{"name":"Center of Epilepsy, Beijing Institute of Brain Disorders, Capital Medical University, Beijing 100069, China"},{"name":"Fundamental Research 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