{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T02:55:17Z","timestamp":1790996117187,"version":"4.1.0"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"14","license":[{"start":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T00:00:00Z","timestamp":1637107200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004004","name":"University of Trento","doi-asserted-by":"publisher","award":["2018\u20132021"],"award-info":[{"award-number":["2018\u20132021"]}],"id":[{"id":"10.13039\/501100004004","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of Trento and Fondazione CARITRO"},{"name":"Umberto Veronesi Foundation"},{"DOI":"10.13039\/100000874","name":"Brain and Behavior Research Foundation","doi-asserted-by":"publisher","award":["26617"],"award-info":[{"award-number":["26617"]}],"id":[{"id":"10.13039\/100000874","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004004","name":"University of Trento","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004004","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006781","name":"Armenise Harvard Foundation","doi-asserted-by":"publisher","award":["400101"],"award-info":[{"award-number":["400101"]}],"id":[{"id":"10.13039\/100006781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000874","name":"Brain and Behavior Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000874","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["GA802371"],"award-info":[{"award-number":["GA802371"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["1R21MH116473-01A1"],"award-info":[{"award-number":["1R21MH116473-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002426","name":"Telethon Foundation","doi-asserted-by":"publisher","award":["GGP19177"],"award-info":[{"award-number":["GGP19177"]}],"id":[{"id":"10.13039\/501100002426","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Abnormal tactile response is an integral feature of Autism Spectrum Disorders (ASDs), and hypo-responsiveness to tactile stimuli is often associated with the severity of ASDs core symptoms. Patients with Phelan-McDermid syndrome (PMS), caused by mutations in the SHANK3 gene, show ASD-like symptoms associated with aberrant tactile responses. The neural underpinnings of these abnormalities are still poorly understood. Here we investigated, in Shank3b\u2212\/\u2212 adult mice, the neural substrates of whisker-guided behaviors, a key component of rodents\u2019 interaction with the surrounding environment. We assessed whisker-dependent behaviors in Shank3b\u2212\/\u2212 adult mice and age-matched controls, using the textured novel object recognition (tNORT) and whisker nuisance (WN) test. Shank3b\u2212\/\u2212 mice showed deficits in whisker-dependent texture discrimination in tNORT and behavioral hypo-responsiveness to repetitive whisker stimulation in WN. Sensory hypo-responsiveness was accompanied by a significantly reduced activation of the primary somatosensory cortex (S1) and hippocampus, as measured by c-fos mRNA induction, a proxy of neuronal activity following whisker stimulation. Moreover, resting-state fMRI showed a significantly reduced S1-hippocampal connectivity in Shank3b mutants, in the absence of altered connectivity between S1 and other somatosensory areas. Impaired crosstalk between hippocampus and S1 might underlie Shank3b\u2212\/\u2212 hypo-reactivity to whisker-dependent cues, highlighting a potentially generalizable somatosensory dysfunction in ASD.<\/jats:p>","DOI":"10.1093\/cercor\/bhab399","type":"journal-article","created":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T16:15:13Z","timestamp":1633709713000},"page":"3042-3056","source":"Crossref","is-referenced-by-count":55,"title":["Abnormal whisker-dependent behaviors and altered cortico-hippocampal connectivity in\n                    <i>Shank3b<\/i>\n                    \u2212\/\u2212 mice"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5750-8505","authenticated-orcid":false,"given":"Luigi","family":"Balasco","sequence":"first","affiliation":[{"name":"CIMeC - Center for Mind\/Brain Sciences , University of Trento, 38068 Rovereto, TN, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Pagani","sequence":"additional","affiliation":[{"name":"Functional Neuroimaging Laboratory , Center for Neuroscience and Cognitive Systems, Istituto Italiano di Tecnologia, 38068 Rovereto, TN, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Pangrazzi","sequence":"additional","affiliation":[{"name":"CIMeC - Center for Mind\/Brain Sciences , University of Trento, 38068 Rovereto, TN, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Chelini","sequence":"additional","affiliation":[{"name":"CIMeC - Center for Mind\/Brain Sciences , University of Trento, 38068 Rovereto, TN, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra Georgette","family":"Ciancone Chama","sequence":"additional","affiliation":[{"name":"CIMeC - Center for Mind\/Brain Sciences , University of Trento, 38068 Rovereto, TN, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgenia","family":"Shlosman","sequence":"additional","affiliation":[{"name":"CIMeC - Center for Mind\/Brain Sciences , University of Trento, 38068 Rovereto, TN, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Mattioni","sequence":"additional","affiliation":[{"name":"Department of Cellular , Computational, and Integrative Biology (CIBIO), University of Trento, 38123 Trento, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Galbusera","sequence":"additional","affiliation":[{"name":"Functional Neuroimaging Laboratory , Center for Neuroscience and Cognitive Systems, Istituto Italiano di Tecnologia, 38068 Rovereto, TN, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliano","family":"Iurilli","sequence":"additional","affiliation":[{"name":"Systems Neurobiology Laboratory , Center for Neuroscience and Cognitive Systems, Istituto Italiano di Tecnologia, 38068 Rovereto, TN, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Provenzano","sequence":"additional","affiliation":[{"name":"Department of Cellular , Computational, and Integrative Biology (CIBIO), University of Trento, 38123 Trento, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Gozzi","sequence":"additional","affiliation":[{"name":"Functional Neuroimaging Laboratory , Center for Neuroscience and Cognitive Systems, Istituto Italiano di Tecnologia, 38068 Rovereto, TN, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Bozzi","sequence":"additional","affiliation":[{"name":"CIMeC - Center for Mind\/Brain Sciences , University of Trento, 38068 Rovereto, TN, Italy"},{"name":"CNR Neuroscience Institute , 56124 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,11,18]]},"reference":[{"key":"2022082415203906700_ref1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/BF02213989","article-title":"The role of vibrissae in behavior: a status review","volume":"10","author":"Ahl","year":"1986","journal-title":"Vet Res Commun"},{"key":"2022082415203906700_ref2","doi-asserted-by":"crossref","DOI":"10.1176\/appi.books.9780890425596","volume-title":"Diagnostic and statistical manual of mental disorders: DSM-5","author":"American Psychiatric Association DSMTF","year":"2013"},{"key":"2022082415203906700_ref3","doi-asserted-by":"crossref","first-page":"107000","DOI":"10.1016\/j.nlm.2019.02.010","article-title":"Home-cage hypoactivity in mouse genetic models of autism spectrum disorder","volume":"165","author":"Angelakos","year":"2019","journal-title":"Neurobiol Learn 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