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Can disease-differential alterations be captured across such dimensions using naturalistic stimuli? To address this question, we assessed comprehension of four naturalistic stories, highlighting action, nonaction, social, and nonsocial events, in Parkinson\u2019s disease (PD) and behavioral variant frontotemporal dementia (bvFTD) relative to Alzheimer\u2019s disease patients and healthy controls. Text-specific correlates were evaluated via voxel-based morphometry, spatial (fMRI), and temporal (hd-EEG) functional connectivity. PD patients presented action\u2013text deficits related to the volume of action\u2013observation regions, connectivity across motor-related and multimodal-semantic hubs, and frontal hd-EEG hypoconnectivity. BvFTD patients exhibited social\u2013text deficits, associated with atrophy and spatial connectivity patterns along social-network hubs, alongside right frontotemporal hd-EEG hypoconnectivity. Alzheimer\u2019s disease patients showed impairments in all stories, widespread atrophy and spatial connectivity patterns, and heightened occipitotemporal hd-EEG connectivity. Our framework revealed disease-specific signatures across behavioral, neuroanatomical, and neurofunctional dimensions, highlighting the sensitivity and specificity of a single naturalistic task. This investigation opens a translational agenda combining ecological approaches and multimodal cognitive neuroscience for the study of neurodegeneration.<\/jats:p>","DOI":"10.1093\/cercor\/bhab421","type":"journal-article","created":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T04:09:08Z","timestamp":1635826148000},"page":"3377-3391","source":"Crossref","is-referenced-by-count":39,"title":["Multimodal neurocognitive markers of naturalistic discourse typify diverse neurodegenerative diseases"],"prefix":"10.1093","volume":"32","author":[{"given":"Agustina","family":"Birba","sequence":"first","affiliation":[{"name":"Centro de Neurociencias Cognitivas , Universidad de San Andr\u00e9s, B1644BID Buenos Aires, Argentina"},{"name":"National Scientific and Technical Research Council (CONICET) , C1425FQD Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sol","family":"Fittipaldi","sequence":"additional","affiliation":[{"name":"Centro de Neurociencias 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