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Despite its candidacy for influencing language development, few preclinical studies have examined the role of CNTNAP2 in auditory processing. Using in vivo and in vitro electrophysiological recordings in a rat model with translational validity, we report that a loss of the Cntnap2 gene function caused immature-like cortical evoked potentials, delayed multiunit response latencies to acoustic stimuli, impaired temporal processing, and led to a pattern of hyperexcitability in both multiunit and single cell recordings in adulthood. These collective results provide direct evidence that a constitutive loss of Cntnap2 gene function in rats can cause auditory processing impairments similar to those seen in language-related human disorders, indicating that its contribution in maintaining cortical neuron excitability may underlie the cortical activity alterations observed in Cntnap2\u2212\/\u2212 rats.<\/jats:p>","DOI":"10.1093\/cercor\/bhab517","type":"journal-article","created":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T12:13:14Z","timestamp":1643199194000},"page":"4797-4817","source":"Crossref","is-referenced-by-count":20,"title":["Hyperexcitable and immature-like neuronal activity in the auditory cortex of adult rats lacking the language-linked <i>CNTNAP2<\/i> gene"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5707-6231","authenticated-orcid":false,"given":"Kaela E","family":"Scott","sequence":"first","affiliation":[{"name":"Department of Anatomy and Cell Biology , Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajkamalpreet S","family":"Mann","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology , Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley L","family":"Schormans","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology , Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5366-8061","authenticated-orcid":false,"given":"Susanne","family":"Schmid","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology , Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian L","family":"Allman","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology , Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,2,1]]},"reference":[{"issue":"24","key":"2022110204483358400_ref1a","doi-asserted-by":"crossref","first-page":"4665","DOI":"10.1042\/BCJ20160668","article-title":"Differential effects of pannexins on noise-induced hearing loss","volume":"473","year":"2016","journal-title":"Biochem J"},{"issue":"4","key":"2022110204483358400_ref1","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.neuron.2018.12.026","article-title":"Increased excitation-inhibition ratio stabilizes synapse and circuit excitability in four autism mouse 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