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This study explored the whole-brain functional networks in early-stage PD-M. Forty-one patients with PD classified as cognitively normal (PD-N, n\u2009=\u200917) and PD-M (n\u2009=\u200924) and 24 demographically matched healthy controls (HC) underwent clinical and neuropsychological evaluations and resting-state functional magnetic resonance imaging. The global, regional, and modular topological characteristics were assessed in the brain functional networks, and their relationships to cognitive scores were tested. At the global level, PD-M and PD-N exhibited higher characteristic path length and lower clustering coefficient, local and global efficiency relative to HC. At the regional level, PD-M and PD-N showed lower nodal centrality in sensorimotor regions relative to HC. At the modular level, PD-M showed lower intramodular connectivity in default mode and cerebellum modules, and lower intermodular connectivity between default mode and frontoparietal modules than PD-N, correlated with Montreal Cognitive Assessment scores. Early-stage PD patients showed weaker small-worldization of brain networks. Modular connectivity alterations were mainly observed in patients with PD-M. These findings highlight the shared and distinct brain functional network dysfunctions in PD-M and PD-N, and yield insight into the neurobiology of cognitive decline in PD.<\/jats:p>","DOI":"10.1093\/cercor\/bhab520","type":"journal-article","created":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T12:12:36Z","timestamp":1640088756000},"page":"4857-4868","source":"Crossref","is-referenced-by-count":38,"title":["Brain functional network abnormalities in parkinson\u2019s disease with mild cognitive impairment"],"prefix":"10.1093","volume":"32","author":[{"given":"Xueling","family":"Suo","sequence":"first","affiliation":[{"name":"Huaxi MR Research Center (HMRRC) , Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041 , China"},{"name":"Research Unit of Psychoradiology , Chinese Academy of Medical Sciences, Chengdu, Sichuan 610041 , China"},{"name":"Functional and Molecular Imaging Key Laboratory of Sichuan Province , West China Hospital of Sichuan University, Chengdu, Sichuan 610041 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Du","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Neuroscience , University of Cincinnati, Cincinnati, OH 45227 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nannan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology , West China Hospital of Sichuan University, Chengdu, Sichuan 610041 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Neurology , West China Hospital of Sichuan University, Chengdu, Sichuan 610041 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaolan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology , West China Hospital of Sichuan University, Chengdu, Sichuan 610041 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Li","sequence":"additional","affiliation":[{"name":"Huaxi MR Research Center (HMRRC) , Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Qin","sequence":"additional","affiliation":[{"name":"Huaxi MR Research Center (HMRRC) , Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham J","family":"Kemp","sequence":"additional","affiliation":[{"name":"Liverpool Magnetic Resonance Imaging Centre (LiMRIC) and Institute of Life Course and Medical Sciences , University of Liverpool, Liverpool L69 3GE , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Neurology , 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