{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T21:15:32Z","timestamp":1781817332480,"version":"3.54.5"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"23","license":[{"start":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T00:00:00Z","timestamp":1645574400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171463"],"award-info":[{"award-number":["82171463"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Clinical Technological Innovative Cultivation Project of Army Medical University","award":["CX20109JS210"],"award-info":[{"award-number":["CX20109JS210"]}]},{"name":"Clinical New Technological Project of the Second Affiliated Hospital of Army Medical University","award":["2021JSLC0002"],"award-info":[{"award-number":["2021JSLC0002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Temporal lobe epilepsy (TLE) is the most common drug-resistant epilepsy in adults, with pathological mechanisms remaining to be fully elucidated. Fibroblast Growth Factor 13 (FGF13) encodes an intracellular protein involved in microtubule stabilization and regulation of voltage-gated sodium channels (VGSCs) function. FGF13 mutation has been identified in patients with inherent seizure, suggesting a potential association between FGF13 and the etiology of TLE. Here, we set to explore the pathological role of FGF13 in the etiology of TLE.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We found that the expression of FGF13 was increased in the cortical lesions and CA1 region of sclerotic hippocampus and correlated with the seizure frequency in TLE patients. Also, Fgf13 expression was increased in the hippocampus of chronic TLE mice generated by kainic acid (KA) injection. Furthermore, Fgf13 knockdown or overexpression was respectively found to attenuate or potentiate the effects of KA on axonal length, somatic area and the VGSCs-mediated current in the hippocampal neurons.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Taken together, these findings suggest that FGF13 is involved in the pathogenesis of TLE by modulating microtubule activity and neuronal excitability.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/cercor\/bhac012","type":"journal-article","created":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T12:08:38Z","timestamp":1642075718000},"page":"5259-5272","source":"Crossref","is-referenced-by-count":15,"title":["Fibroblast growth factor 13 is involved in the pathogenesis of temporal lobe epilepsy"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8373-8275","authenticated-orcid":false,"given":"Kai-Feng","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Neurosurgery , Xinqiao Hospital, , 183 Xinqiao Main Street, Shapingba District, Chongqing 400037, China"},{"name":"Army Medical University , Xinqiao Hospital, , 183 Xinqiao Main Street, Shapingba District, Chongqing 400037, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiong","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery , Xinqiao Hospital, , 183 Xinqiao Main Street, Shapingba District, Chongqing 400037, China"},{"name":"Army Medical University , Xinqiao Hospital, , 183 Xinqiao Main Street, Shapingba District, Chongqing 400037, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Feng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pedatrics , Xinqiao Hospital, , 183 Xinqiao Main Street, Shapingba District, Chongqing 400037, China"},{"name":"Army Medical University , Xinqiao Hospital, , 183 Xinqiao Main Street, Shapingba District, Chongqing 400037, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke-Fu","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery , Xinqiao Hospital, , 183 Xinqiao Main Street, Shapingba District, Chongqing 400037, China"},{"name":"Army Medical University , Xinqiao Hospital, , 183 Xinqiao Main Street, Shapingba District, Chongqing 400037, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery , Xinqiao Hospital, , 183 Xinqiao Main Street, Shapingba District, Chongqing 400037, China"},{"name":"Army Medical University , Xinqiao Hospital, , 183 Xinqiao Main Street, Shapingba District, Chongqing 400037, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Lin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery , Xinqiao Hospital, , 183 Xinqiao Main Street, Shapingba District, Chongqing 400037, China"},{"name":"Army Medical University , Xinqiao Hospital, , 183 Xinqiao Main Street, Shapingba District, Chongqing 400037, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong-Ke","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery , Xinqiao Hospital, , 183 Xinqiao Main Street, Shapingba District, Chongqing 400037, China"},{"name":"Army Medical University , Xinqiao Hospital, , 183 Xinqiao Main Street, Shapingba District, Chongqing 400037, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pain Management , Henan Provincial People\u2019s hospital, 7 Weiwu Road, Jinshui District, Zhengzhou 450008, China"},{"name":"Zhongshan Medical School , Sun Yat-sen University, 74 Zhongshan Second Road, Yuexiu District, Guangzhou 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Yong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery , Xinqiao Hospital, , 183 Xinqiao Main Street, Shapingba District, Chongqing 400037, China"},{"name":"Army Medical University , Xinqiao Hospital, , 183 Xinqiao Main Street, Shapingba District, Chongqing 400037, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6484-2328","authenticated-orcid":false,"given":"Hui","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery , Xinqiao Hospital, , 183 Xinqiao Main Street, Shapingba District, Chongqing 400037, China"},{"name":"Army Medical University , Xinqiao Hospital, , 183 Xinqiao Main Street, Shapingba District, Chongqing 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