{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T18:40:21Z","timestamp":1787856021259,"version":"build-2784847793"},"reference-count":150,"publisher":"Oxford University Press (OUP)","issue":"23","license":[{"start":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T00:00:00Z","timestamp":1646697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH111794"],"award-info":[{"award-number":["R01MH111794"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R21\/R33MH107589"],"award-info":[{"award-number":["R21\/R33MH107589"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,21]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Patients with obsessive\u2013compulsive disorder (OCD) exhibit abnormality in their subjective perception of internal sensation, a process known as interoceptive sensibility (IS), as well as altered functioning of the insula, a key neural structure for interoception. We investigated the multivariate structure of IS in 77 OCD patients and 53 controls and examined associations of IS with resting-state functional connectivity (FC) of the insula within the OCD group. For each group, principal component analysis was performed on 8 subscales of the Multidimensional Assessment of Interoceptive Awareness assessing putatively \u201cadaptive\u201d and \u201cmaladaptive\u201d aspects of IS. Associations between IS components and insula FC in the OCD group were evaluated using seed regions placed in each of 3 subdivisions of the insula (posterior, anterior dorsal, and anterior ventral). Behaviorally, controls showed a 2-component solution broadly categorized into \u201cadaptive\u201d and \u201cmaladaptive\u201d IS, while OCD patients exhibited a 3-component solution. The general tendency to notice or be aware of sensation loaded onto an \u201cadaptive\u201d IS component in controls but loaded onto both \u201cadaptive\u201d and \u201cmaladaptive\u201d IS components in OCD. Within OCD, insula FC was differentially associated with distinct aspects of IS, identifying network connections that could serve as future targets for the modulation of IS in OCD.<\/jats:p>","DOI":"10.1093\/cercor\/bhac014","type":"journal-article","created":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T20:14:47Z","timestamp":1643228087000},"page":"5285-5300","source":"Crossref","is-referenced-by-count":20,"title":["Relationships between interoceptive sensibility and resting-state functional connectivity of the insula in obsessive\u2013compulsive disorder"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7189-2868","authenticated-orcid":false,"given":"Goi Khia","family":"Eng","sequence":"first","affiliation":[{"name":"Department of Psychiatry , New York University School of Medicine, One Park Ave, 8th Floor, New York, NY 10016 , United States"},{"name":"Nathan S. Kline Institute for Psychiatric Research , 140 Old Orangeburg Road, Orangeburg, NY 10962 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine A","family":"Collins","sequence":"additional","affiliation":[{"name":"Nathan S. Kline Institute for Psychiatric Research , 140 Old Orangeburg Road, Orangeburg, NY 10962 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina","family":"Brown","sequence":"additional","affiliation":[{"name":"San Diego State University\/University of California San Diego Joint Doctoral Program in Clinical Psychology , 6363 Alvarado Court, San Diego, CA 92120 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly","family":"Ludlow","sequence":"additional","affiliation":[{"name":"Ferkauf Graduate School of Psychology , 1165 Morris Park Ave, Bronx, NY 10461 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell H","family":"Tobe","sequence":"additional","affiliation":[{"name":"Nathan S. Kline Institute for Psychiatric Research , 140 Old Orangeburg Road, Orangeburg, NY 10962 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan V","family":"Iosifescu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry , New York University School of Medicine, One Park Ave, 8th Floor, New York, NY 10016 , United States"},{"name":"Nathan S. Kline Institute for Psychiatric Research , 140 Old Orangeburg Road, Orangeburg, NY 10962 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily R","family":"Stern","sequence":"additional","affiliation":[{"name":"Department of Psychiatry , New York University School of Medicine, One Park Ave, 8th Floor, New York, NY 10016 , United States"},{"name":"Nathan S. 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