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Despite its promising clinical outcome, the exact mechanism of how ANT-DBS alleviates seizure severity has not been fully understood, especially at the cellular level. To assess effects of DBS, the present study examined electroencephalography (EEG) signals and locomotor behavior changes and conducted immunohistochemical analyses to examine changes in neuronal activity, number of neurons, and neurogenesis of inhibitory neurons in different hippocampal subregions. ANT-DBS alleviated seizure activity, abnormal locomotor behaviors, reduced theta-band, increased gamma-band EEG power in the interictal state, and increased the number of neurons in the dentate gyrus (DG). The number of parvalbumin- and somatostatin-expressing inhibitory neurons was recovered to the level in DG and CA1 of na\u00efve mice. Notably, BrdU-positive inhibitory neurons were increased. In conclusion, ANT-DBS not only could reduce the number of seizures, but also could induce neuronal changes in the hippocampus, which is a key region involved in chronic epileptogenesis. Importantly, our results suggest that ANT-DBS may lead to hippocampal subregion-specific cellular recovery of GABAergic inhibitory neurons.<\/jats:p>","DOI":"10.1093\/cercor\/bhac033","type":"journal-article","created":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T20:12:19Z","timestamp":1643055139000},"page":"5530-5543","source":"Crossref","is-referenced-by-count":14,"title":["Deep brain stimulation of the anterior nuclei of the thalamus can alleviate seizure severity and induce hippocampal GABAergic neuronal changes in a pilocarpine-induced epileptic mouse brain"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3089-0270","authenticated-orcid":false,"given":"Sungjun","family":"Bae","sequence":"first","affiliation":[{"name":"Center for Neuroscience Imaging Research (CNIR) , , Suwon 16419 , South Korea"},{"name":"Institute for Basic Science (IBS) , , Suwon 16419 , South Korea"},{"name":"Department of Biomedical Engineering , , Suwon 16419 , South Korea"},{"name":"Sungkyunkwan University , , Suwon 16419 , South Korea"},{"name":"IMNEWRUN Inc. , N Center Bldg. 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