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Intratelencephalic (IT) cells in layer 5 (L5) contribute feedback projections to diverse cortical areas. Here we show that L5 IT cells participating in feedback connections to layer 1 (L1) exhibit distinct projection patterns, genetic profiles, and electrophysiological properties relative to other L5 IT cells. An analysis of the MouseLight database found that L5 IT cells preferentially targeting L1 project broadly to more cortical regions, including the perirhinal and auditory cortices, and innervate a larger volume of striatum than the other L5 IT cells. We found experimentally that in upper L5 (L5a), ER81 (ETV1) was found more often in L1-preferring IT cells, and in IT cells projecting to perirhinal\/auditory regions than those projecting to primary motor or somatosensory regions. The perirhinal region-projecting L5a IT cells were synaptically connected to each other and displayed lower input resistance than contra-M2 projecting IT cells including L1-preferring and nonpreferring cells. Our findings suggest that M2-L5a IT L1-preferring cells exhibit stronger ER81 expression and broader cortical\/striatal projection fields than do cells that do not preferentially target L1.<\/jats:p>","DOI":"10.1093\/cercor\/bhac052","type":"journal-article","created":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T20:13:25Z","timestamp":1643314405000},"page":"50-67","source":"Crossref","is-referenced-by-count":8,"title":["Corticocortical innervation subtypes of layer 5 intratelencephalic cells in the murine secondary motor cortex"],"prefix":"10.1093","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3416-4903","authenticated-orcid":false,"given":"Sanghun","family":"Im","sequence":"first","affiliation":[{"name":"National Institute for Physiological Sciences (NIPS) , Okazaki 444-8787 , Japan"},{"name":"Department of Physiological Sciences , , Okazaki 444-8787 , Japan"},{"name":"The Graduate University for Advanced Studies (SOKENDAI) , , Okazaki 444-8787 , Japan"},{"name":"Brain Science Institute , Tamagawa University, Machida, Tokyo 194-8610 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3073-9899","authenticated-orcid":false,"given":"Yoshifumi","family":"Ueta","sequence":"additional","affiliation":[{"name":"Department of Physiology , Division of Neurophysiology, , Tokyo 162-8666 , Japan"},{"name":"School of Medicine, Tokyo Women's Medical University , Division of Neurophysiology, , Tokyo 162-8666 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Otsuka","sequence":"additional","affiliation":[{"name":"National Institute for Physiological Sciences (NIPS) , Okazaki 444-8787 , Japan"},{"name":"Department of Physiological Sciences , , Okazaki 444-8787 , Japan"},{"name":"The Graduate University for Advanced Studies (SOKENDAI) , , Okazaki 444-8787 , 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