{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:49:39Z","timestamp":1791485379989,"version":"4.3.4"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T00:00:00Z","timestamp":1647820800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Human Brain Project Specific Grant Agreement 3","award":["945539"],"award-info":[{"award-number":["945539"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Understanding the brain changes occurring during aging can provide new insights for developing treatments that alleviate or reverse cognitive decline. Neurostimulation techniques have emerged as potential treatments for brain disorders and to improve cognitive functions. Nevertheless, given the ethical restrictions of neurostimulation approaches, in silico perturbation protocols based on causal whole-brain models are fundamental to gaining a mechanistic understanding of brain dynamics. Furthermore, this strategy could serve to identify neurophysiological biomarkers differentiating between age groups through an exhaustive exploration of the global effect of all possible local perturbations. Here, we used a resting-state fMRI dataset divided into middle-aged (N =310, &amp;lt;65 years) and older adults (N =310, $\\geq $65) to characterize brain states in each group as a probabilistic metastable substate (PMS) space. We showed that the older group exhibited a reduced capability to access a metastable substate that overlaps with the rich club. Then, we fitted the PMS to a whole-brain model and applied in silico stimulations in each node to force transitions from the brain states of the older- to the middle-aged group. We found that the precuneus was the best stimulation target. Overall, these findings could have important implications for designing neurostimulation interventions for reversing the effects of aging on whole-brain dynamics.<\/jats:p>","DOI":"10.1093\/cercor\/bhac064","type":"journal-article","created":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T08:35:56Z","timestamp":1644914156000},"page":"235-245","source":"Crossref","is-referenced-by-count":29,"title":["The effect of external stimulation on functional networks in the aging healthy human brain"],"prefix":"10.1093","volume":"33","author":[{"given":"Anira","family":"Escrichs","sequence":"first","affiliation":[{"name":"Computational Neuroscience Group , Center for Brain and Cognition, Department of Information and Communication Technologies, Universitat Pompeu Fabra, Barcelona, Catalonia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonatan","family":"Sanz Perl","sequence":"additional","affiliation":[{"name":"Computational Neuroscience Group , Center for Brain and Cognition, Department of Information and Communication Technologies, Universitat Pompeu Fabra, Barcelona, Catalonia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noelia","family":"Mart\u00ednez-Molina","sequence":"additional","affiliation":[{"name":"Computational Neuroscience Group , Center for Brain and Cognition, Department of Information and Communication Technologies, Universitat Pompeu Fabra, Barcelona, Catalonia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carles","family":"Biarnes","sequence":"additional","affiliation":[{"name":"Department of Radiology (IDI) , Hospital Universitari de Girona Dr Josep Trueta, Girona, Spain"},{"name":"Girona Biomedical Research Institute (IDIBGI) , Hospital Universitari de Girona Dr Josep Trueta, Girona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Garre-Olmo","sequence":"additional","affiliation":[{"name":"Girona Biomedical Research Institute (IDIBGI) , Hospital Universitari de Girona Dr Josep Trueta, Girona, Spain"},{"name":"Department of Medical Sciences , School of Medicine, University of Girona, Girona, Spain"},{"name":"Institut d\u2019Assist\u00e8ncia Sanit\u00e0ria , Salt, Girona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Manuel","family":"Fern\u00e1ndez-Real","sequence":"additional","affiliation":[{"name":"Girona Biomedical Research Institute (IDIBGI) , Hospital Universitari de Girona Dr Josep Trueta, Girona, Spain"},{"name":"Department of Medical Sciences , School of Medicine, University of Girona, Girona, Spain"},{"name":"Department of Diabetes , Endocrinology and Nutrition, IDIBGI, Hospital Universitari de Girona Dr Josep Trueta, and CIBER Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBERobn), Girona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafel","family":"Ramos","sequence":"additional","affiliation":[{"name":"Girona Biomedical Research Institute (IDIBGI) , Hospital Universitari de Girona Dr Josep Trueta, Girona, Spain"},{"name":"Department of Medical Sciences , School of Medicine, University of Girona, Girona, Spain"},{"name":"Vascular Health Research Group of Girona (ISV-Girona) , Institut Universitari d\u2019Investigaci\u00f3 en Atenci\u00f3 Prim\u00e0ria Jordi Gol (IDIAP Jordi Gol), Girona, Spain"},{"name":"Primary Care Services , Catalan Institute of Health (ICS), Girona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Mart\u00ed","sequence":"additional","affiliation":[{"name":"Girona Biomedical Research Institute (IDIBGI) , Hospital Universitari de Girona Dr Josep Trueta, Girona, Spain"},{"name":"Vascular Health Research Group of Girona (ISV-Girona) , Institut Universitari d\u2019Investigaci\u00f3 en Atenci\u00f3 Prim\u00e0ria Jordi Gol (IDIAP Jordi Gol), Girona, Spain"},{"name":"Primary Care Services , Catalan Institute of Health (ICS), Girona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinald","family":"Pamplona","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine , Faculty of Medicine, University of Lleida-IRBLleida, Lleida, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramon","family":"Brugada","sequence":"additional","affiliation":[{"name":"Girona Biomedical Research Institute (IDIBGI) , Hospital Universitari de Girona Dr Josep Trueta, Girona, Spain"},{"name":"Department of Medical Sciences , School of Medicine, University of Girona, Girona, Spain"},{"name":"Cardiovascular Genetics Center , IDIBGI, CIBER-CV, Girona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquin","family":"Serena","sequence":"additional","affiliation":[{"name":"Girona Biomedical Research Institute (IDIBGI) , Hospital Universitari de Girona Dr Josep Trueta, Girona, Spain"},{"name":"Department of Medical Sciences , School of Medicine, University of Girona, Girona, Spain"},{"name":"Department of Neurology , Hospital Universitari de Girona Dr Josep Trueta, Girona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Llu\u00eds","family":"Rami\u00f3-Torrent\u00e0","sequence":"additional","affiliation":[{"name":"Girona Biomedical Research Institute (IDIBGI) , Hospital Universitari de Girona Dr Josep Trueta, Girona, Spain"},{"name":"Department of Medical Sciences , School of Medicine, University of Girona, Girona, Spain"},{"name":"Department of Neurology , Hospital Universitari de Girona Dr Josep Trueta, Girona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Coll-De-Tuero","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences , School of Medicine, University of Girona, Girona, Spain"},{"name":"Vascular Health Research Group of Girona (ISV-Girona) , Institut Universitari d\u2019Investigaci\u00f3 en Atenci\u00f3 Prim\u00e0ria Jordi Gol (IDIAP Jordi Gol), Girona, Spain"},{"name":"CIBER of Epidemiology and Public Health (CIBERESP) , Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00eds","family":"Gallart","sequence":"additional","affiliation":[{"name":"Biobanc, Girona Biomedical Research Institute (IDIBGI) , Girona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Barretina","sequence":"additional","affiliation":[{"name":"Girona Biomedical Research Institute (IDIBGI) , Hospital Universitari de Girona Dr Josep Trueta, Girona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan C","family":"Vilanova","sequence":"additional","affiliation":[{"name":"Department of Radiology (IDI) , Hospital Universitari de Girona Dr Josep Trueta, Girona, Spain"},{"name":"Girona Biomedical Research Institute (IDIBGI) , Hospital Universitari de Girona Dr Josep Trueta, Girona, Spain"},{"name":"Department of Medical Sciences , School of Medicine, University of Girona, Girona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Mayneris-Perxachs","sequence":"additional","affiliation":[{"name":"Girona Biomedical Research Institute (IDIBGI) , Hospital Universitari de Girona Dr Josep Trueta, Girona, Spain"},{"name":"Department of Diabetes , Endocrinology and Nutrition, IDIBGI, Hospital Universitari de Girona Dr Josep Trueta, and CIBER Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBERobn), Girona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Saba","sequence":"additional","affiliation":[{"name":"Department of Radiology , AOU Cagliari, University of Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvador","family":"Pedraza","sequence":"additional","affiliation":[{"name":"Department of Radiology (IDI) , Hospital Universitari de Girona Dr Josep Trueta, Girona, Spain"},{"name":"Girona Biomedical Research Institute (IDIBGI) , Hospital Universitari de Girona Dr Josep Trueta, Girona, Spain"},{"name":"Department of Medical Sciences , School of Medicine, University of Girona, Girona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten L","family":"Kringelbach","sequence":"additional","affiliation":[{"name":"Centre for Eudaimonia and Human Flourishing , University of Oxford, Oxford, UK"},{"name":"Department of Psychiatry , University of Oxford, Oxford, UK"},{"name":"Center for Music in the Brain , Department of Clinical Medicine, Aarhus University, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Puig","sequence":"additional","affiliation":[{"name":"Department of Radiology (IDI) , Hospital Universitari de Girona Dr Josep Trueta, Girona, Spain"},{"name":"Girona Biomedical Research Institute (IDIBGI) , Hospital Universitari de Girona Dr Josep Trueta, Girona, Spain"},{"name":"Department of Medical Sciences , School of Medicine, University of Girona, Girona, Spain"},{"name":"Institut d\u2019Assist\u00e8ncia Sanit\u00e0ria , Salt, Girona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Deco","sequence":"additional","affiliation":[{"name":"Computational Neuroscience Group , Center for Brain and Cognition, Department of Information and Communication Technologies, Universitat Pompeu Fabra, Barcelona, Catalonia, Spain"},{"name":"Instituci\u00f3 Catalana de la Recerca i Estudis Avancats (ICREA) , Barcelona, Catalonia , Spain"},{"name":"Department of Neuropsychology , Max Planck Institute for human Cognitive and Brain Sciences, Leipzig, Germany"},{"name":"Turner Institute for Brain and Mental Health , Monash University, Melbourne, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,3,21]]},"reference":[{"key":"2022121707564689700_ref1","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.neuroimage.2015.10.019","article-title":"An integrated approach to correction for off-resonance effects and subject movement in diffusion MR imaging","volume":"125","author":"Andersson","year":"2016","journal-title":"NeuroImage"},{"key":"2022121707564689700_ref2","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.apmr.2013.09.002","article-title":"Transcranial direct current stimulation effects in disorders of consciousness","volume":"95","author":"Angelakis","year":"2014","journal-title":"Arch Phys Med Rehabil"},{"key":"2022121707564689700_ref3","doi-asserted-by":"crossref","DOI":"10.3410\/B3-22","article-title":"Secrets of aging: what does a normally aging brain look like?","volume":"3","author":"Barnes","year":"2011","journal-title":"F1000 Biol Rep"},{"key":"2022121707564689700_ref4","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1002\/mrm.10609","article-title":"Characterization and propagation of uncertainty in diffusion-weighted MR imaging","volume":"50","author":"Behrens","year":"2003","journal-title":"Magn Reson Med"},{"key":"2022121707564689700_ref5","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.neuroimage.2006.09.018","article-title":"Probabilistic diffusion tractography with multiple fibre orientations: What can we gain?","volume":"34","author":"Behrens","year":"2007","journal-title":"NeuroImage"},{"key":"2022121707564689700_ref6","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.neuroimage.2007.04.042","article-title":"A component based noise correction method (CompCor) for BOLD and perfusion based fMRI","volume":"37","author":"Behzadi","year":"2007","journal-title":"NeuroImage"},{"key":"2022121707564689700_ref7","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/nyas.12110","article-title":"Combined neurostimulation and neuroimaging in cognitive neuroscience: Past, present, and future","volume":"1296","author":"Bestmann","year":"2013","journal-title":"Ann N Y Acad Sci"},{"key":"2022121707564689700_ref8","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.neuroimage.2014.07.067","article-title":"Changes in structural and functional connectivity among resting-state networks across the human lifespan","volume":"102","author":"Betzel","year":"2014","journal-title":"NeuroImage"},{"key":"2022121707564689700_ref9","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.tins.2020.06.005","article-title":"Tapping into Multi-Faceted Human Behavior and Psychopathology Using fMRI Brain Dynamics","volume":"43","author":"Bolton","year":"2020","journal-title":"Trends Neurosci"},{"key":"2022121707564689700_ref10","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/s41583-018-0068-2","article-title":"Maintenance, reserve and compensation: the cognitive neuroscience of healthy ageing","volume":"19","author":"Cabeza","year":"2018","journal-title":"Nat Rev Neurosci"},{"key":"2022121707564689700_ref11","doi-asserted-by":"crossref","first-page":"5135","DOI":"10.1038\/s41598-017-05425-7","article-title":"Cognitive performance in healthy older adults relates to spontaneous switching between states of functional connectivity during rest","volume":"7","author":"Cabral","year":"2017","journal-title":"Sci Rep"},{"key":"2022121707564689700_ref12","doi-asserted-by":"crossref","first-page":"10676","DOI":"10.1523\/JNEUROSCI.4793-12.2013","article-title":"Probabilistic diffusion tractography and graph theory analysis reveal abnormal white matter structural connectivity networks in drug-naive boys with attention deficit\/hyperactivity disorder","volume":"33","author":"Cao","year":"2013","journal-title":"J Neurosci"},{"key":"2022121707564689700_ref13","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.dcn.2013.11.004","article-title":"Topological organization of the human brain functional connectome across the lifespan","volume":"7","author":"Cao","year":"2014","journal-title":"Dev Cogn Neurosci"},{"key":"2022121707564689700_ref14","doi-asserted-by":"crossref","first-page":"198ra105","DOI":"10.1126\/scitranslmed.3006294","article-title":"A theoretically based index of consciousness independent of sensory processing and behavior","volume":"5","author":"Casali","year":"2013","journal-title":"Sci Transl Med"},{"key":"2022121707564689700_ref15","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1093\/brain\/awl004","article-title":"The precuneus: a review of its functional anatomy and behavioural correlates","volume":"129","author":"Cavanna","year":"2006","journal-title":"Brain"},{"key":"2022121707564689700_ref16","first-page":"13","article-title":"DPARSF: A MATLAB toolbox for \"pipeline\" data analysis of resting-state fMRI","volume":"4","author":"Chao-Gan","year":"2010","journal-title":"Front Syst Neurosci"},{"key":"2022121707564689700_ref17","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.neuroimage.2013.08.071","article-title":"Neuroenhancement: enhancing brain and mind in health and in disease","volume":"85","author":"Clark","year":"2014","journal-title":"NeuroImage"},{"key":"2022121707564689700_ref18","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.neuroimage.2017.01.077","article-title":"Effects of aging on functional and structural brain connectivity","volume":"160","author":"Damoiseaux","year":"2017","journal-title":"NeuroImage"},{"key":"2022121707564689700_ref19","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1093\/cercor\/bhm155","article-title":"Que PASA? The posterior-anterior shift in aging","volume":"18","author":"Davis","year":"2008","journal-title":"Cereb Cortex"},{"key":"2022121707564689700_ref20","article-title":"Meditation-induced effects on whole-brain structural and effective connectivity","author":"De Filippi","year":"2021","journal-title":"bioRxiv"},{"key":"2022121707564689700_ref21","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1038\/s41598-017-03073-5","article-title":"The dynamics of resting fluctuations in the brain: metastability and its dynamical cortical core","volume":"7","author":"Deco","year":"2017","journal-title":"Sci Rep"},{"key":"2022121707564689700_ref22","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.neuroimage.2017.12.009","article-title":"Perturbation of whole-brain dynamics in silico reveals mechanistic differences between brain states","volume":"169","author":"Deco","year":"2018","journal-title":"NeuroImage"},{"key":"2022121707564689700_ref23","doi-asserted-by":"crossref","first-page":"18088","DOI":"10.1073\/pnas.1905534116","article-title":"Awakening: predicting external stimulation to force transitions between different brain states","volume":"116","author":"Deco","year":"2019","journal-title":"Proc Natl Acad Sci"},{"key":"2022121707564689700_ref24","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1093\/cercor\/bhaa367","article-title":"Whole-brain dynamics in aging: disruptions in functional connectivity and the role of the rich club","volume":"31","author":"Escrichs","year":"2021","journal-title":"Cereb Cortex"},{"key":"2022121707564689700_ref25","article-title":"Unifying turbulent dynamics framework distinguishes different brain states","author":"Escrichs","year":"2021","journal-title":"bioRxiv"},{"key":"2022121707564689700_ref26","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.neubiorev.2013.01.017","article-title":"Resting-state functional connectivity in normal brain aging","volume":"37","author":"Ferreira","year":"2013","journal-title":"Neurosci Biobehav Rev"},{"key":"2022121707564689700_ref27","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.1002\/hbm.24559","article-title":"Altered ability to access a clinically relevant control network in patients remitted from major depressive disorder","volume":"40","author":"Figueroa","year":"2019","journal-title":"Hum Brain Mapp"},{"key":"2022121707564689700_ref28","first-page":"2303","article-title":"The disconnected brain and executive function decline in aging","volume":"27","author":"Fjell","year":"2017","journal-title":"Cereb Cortex"},{"key":"2022121707564689700_ref29","doi-asserted-by":"crossref","first-page":"E4367","DOI":"10.1073\/pnas.1405003111","article-title":"Resting-state networks link invasive and noninvasive brain stimulation across diverse psychiatric and neurological diseases","volume":"111","author":"Fox","year":"2014","journal-title":"Proc Natl Acad Sci"},{"key":"2022121707564689700_ref30","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1093\/cercor\/bhu012","article-title":"A brain-wide study of age-related changes in functional connectivity","volume":"25","author":"Geerligs","year":"2015","journal-title":"Cereb Cortex"},{"key":"2022121707564689700_ref31","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1089\/brain.2011.0068","article-title":"Functional magnetic resonance imaging phase synchronization as a measure of dynamic functional connectivity","volume":"2","author":"Glerean","year":"2012","journal-title":"Brain Connect"},{"key":"2022121707564689700_ref32","doi-asserted-by":"crossref","first-page":"15684","DOI":"10.1523\/JNEUROSCI.2308-09.2009","article-title":"Age- and gender-related differences in the cortical anatomical network","volume":"29","author":"Gong","year":"2009","journal-title":"J Neurosci"},{"key":"2022121707564689700_ref33","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.neurobiolaging.2016.02.020","article-title":"Age differences in the functional interactions among the default, frontoparietal control, and dorsal attention networks","volume":"41","author":"Grady","year":"2016","journal-title":"Neurobiol Aging"},{"key":"2022121707564689700_ref34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.0060159","article-title":"Mapping the structural core of human cerebral cortex","volume":"6","author":"Hagmann","year":"2008","journal-title":"PLoS Biol"},{"key":"2022121707564689700_ref35","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.trci.2017.04.008","article-title":"Combined mnemonic strategy training and high-definition transcranial direct current stimulation for memory deficits in mild cognitive impairment. Alzheimer\u2019s dement","volume":"3","author":"Hampstead","year":"2017","journal-title":"Transl Res Clin Interv"},{"key":"2022121707564689700_ref36","doi-asserted-by":"crossref","first-page":"15775","DOI":"10.1523\/JNEUROSCI.3539-11.2011","article-title":"Rich-club organization of the human connectome","volume":"31","author":"Heuvel","year":"2011","journal-title":"J Neurosci"},{"key":"2022121707564689700_ref37","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2020.116833","article-title":"Modeling regional changes in dynamic stability during sleep and wakefulness","volume":"215","author":"Ipi\u00f1a","year":"2020","journal-title":"NeuroImage"},{"key":"2022121707564689700_ref38","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108128","article-title":"Brain states and transitions: insights from computational neuroscience","volume":"32","author":"Kringelbach","year":"2020","journal-title":"Cell Rep"},{"key":"2022121707564689700_ref39","doi-asserted-by":"crossref","first-page":"9566","DOI":"10.1073\/pnas.1921475117","article-title":"Dynamic coupling of whole-brain neuronal and neurotransmitter systems","volume":"117","author":"Kringelbach","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2022121707564689700_ref40","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.neuroimage.2016.02.015","article-title":"Transcranial direct current stimulation changes resting state functional connectivity: a large-scale brain network modeling study","volume":"140","author":"Kunze","year":"2016","journal-title":"NeuroImage"},{"key":"2022121707564689700_ref41","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1002\/mrm.21890","article-title":"The B -matrix must be rotated when correcting for subject motion in DTI data","volume":"61","author":"Leemans","year":"2009","journal-title":"Magn Reson Med"},{"key":"2022121707564689700_ref42","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.neubiorev.2015.08.013","article-title":"Putting age-related task activation into large-scale brain networks: a meta-analysis of 114 fMRI studies on healthy aging","volume":"57","author":"Li","year":"2015","journal-title":"Neurosci Biobehav Rev"},{"key":"2022121707564689700_ref43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s42003-021-02537-9","article-title":"Loss of consciousness reduces the stability of brain hubs and the heterogeneity of brain dynamics","volume":"4","author":"L\u00f3pez-Gonz\u00e1lez","year":"2021","journal-title":"Commun Biol"},{"key":"2022121707564689700_ref44","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.neuroimage.2019.05.060","article-title":"Dynamical exploration of the repertoire of brain networks at rest is modulated by psilocybin","volume":"199","author":"Lord","year":"2019","journal-title":"NeuroImage"},{"key":"2022121707564689700_ref45","doi-asserted-by":"crossref","first-page":"1005076","DOI":"10.1371\/journal.pcbi.1005076","article-title":"Stimulation-based control of dynamic brain networks","volume":"12","author":"Muldoon","year":"2016","journal-title":"PLoS Comput Biol"},{"key":"2022121707564689700_ref46","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3389\/fnins.2016.00014","article-title":"Structural brain network characteristics can differentiate CIS from early RRMS","volume":"10","author":"Muthuraman","year":"2016","journal-title":"Front Neurosci"},{"key":"2022121707564689700_ref47","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.plrev.2019.05.002","article-title":"Is temporo-spatial dynamics the \u201ccommon currency\u201d of brain and mind? in quest of \u201cspatiotemporal neuroscience\u201d","volume":"33","author":"Northoff","year":"2020","journal-title":"Phys Life Rev"},{"key":"2022121707564689700_ref48","doi-asserted-by":"crossref","first-page":"8115","DOI":"10.1073\/pnas.1911240117","article-title":"Individualized perturbation of the human connectome reveals reproducible biomarkers of network dynamics relevant to cognition","volume":"117","author":"Ozdemir","year":"2020","journal-title":"Proc Natl Acad Sci"},{"key":"2022121707564689700_ref49","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1016\/j.neurobiolaging.2014.03.012","article-title":"Longitudinal assessment of default-mode brain function in aging","volume":"35","author":"Persson","year":"2014","journal-title":"Neurobiol Aging"},{"key":"2022121707564689700_ref50","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2020.111257","article-title":"The aging imageomics study: rationale, design and baseline characteristics of the study population","volume":"189","author":"Puig","year":"2020","journal-title":"Mech Ageing Dev"},{"key":"2022121707564689700_ref51","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1467-8721.2008.00570.x","article-title":"Neurocognitive aging and the compensation hypothesis","volume":"17","author":"Reuter-Lorenz","year":"2008","journal-title":"Curr Dir Psychol Sci"},{"key":"2022121707564689700_ref52","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1009139","article-title":"Perturbations in dynamical models of whole-brain activity dissociate between the level and stability of consciousness","volume":"17","author":"Sanz Perl","year":"2021","journal-title":"PLoS Comput Biol"},{"key":"2022121707564689700_ref53","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.neuroimage.2013.05.081","article-title":"Groupwise whole-brain parcellation from resting-state fMRI data for network node identification","volume":"82","author":"Shen","year":"2013","journal-title":"NeuroImage"},{"key":"2022121707564689700_ref54","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/hbm.10062","article-title":"Fast robust automated brain extraction","volume":"17","author":"Smith","year":"2002","journal-title":"Hum Brain Mapp"},{"key":"2022121707564689700_ref55","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0068-16.2016","article-title":"Selective activation of resting-state networks following focal stimulation in a connectome-based network model of the human brain","volume":"3","author":"Spiegler","year":"2016","journal-title":"Eneuro"},{"key":"2022121707564689700_ref56","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.conb.2012.11.015","article-title":"Network attributes for segregation and integration in the human brain","volume":"23","author":"Sporns","year":"2013","journal-title":"Curr Opin Neurobiol"},{"key":"2022121707564689700_ref57","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.neurobiolaging.2016.05.020","article-title":"Attenuated anticorrelation between the default and dorsal attention networks with aging: evidence from task and rest","volume":"45","author":"Spreng","year":"2016","journal-title":"Neurobiol Aging"},{"key":"2022121707564689700_ref58","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1212\/WNL.0000000000000260","article-title":"TDCS in patients with disorders of consciousness: Sham-controlled randomized double-blind study","volume":"82","author":"Thibaut","year":"2014","journal-title":"Neurology"},{"key":"2022121707564689700_ref59","volume-title":"World population ageing 2019","author":"United Nations","year":"2019"},{"key":"2022121707564689700_ref60","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1523\/JNEUROSCI.4227-13.2014","article-title":"Precuneus is a functional core of the default-mode network","volume":"34","author":"Utevsky","year":"2014","journal-title":"J Neurosci"},{"key":"2022121707564689700_ref61","doi-asserted-by":"crossref","first-page":"11372","DOI":"10.1073\/pnas.1203593109","article-title":"High-cost, high-capacity backbone for global brain communication","volume":"109","author":"Van Den Heuvel","year":"2012","journal-title":"Proc Natl Acad Sci"},{"key":"2022121707564689700_ref62","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.neuroimage.2010.02.046","article-title":"Intrinsic connectivity between the hippocampus and posteromedial cortex predicts memory performance in cognitively intact older individuals","volume":"51","author":"Wang","year":"2010","journal-title":"NeuroImage"},{"key":"2022121707564689700_ref63","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1089\/brain.2012.0073","article-title":"Conn : a functional connectivity toolbox for correlated and anticorrelated brain networks","volume":"2","author":"Whitfield-Gabrieli","year":"2012","journal-title":"Brain Connect"},{"key":"2022121707564689700_ref64","article-title":"WHO | Proposed working definition of an older person in Africa for the MDS Project","author":"WHO","year":"2016","journal-title":"World Heal Organ"},{"key":"2022121707564689700_ref65","first-page":"1","article-title":"Age differences of the hierarchical cognitive control and the frontal rostro-caudal functional brain activation","author":"Yao","year":"2021","journal-title":"Cereb Cortex"},{"key":"2022121707564689700_ref66","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1109\/TBME.2018.2845689","article-title":"Antidepressant-like effect of low-intensity transcranial ultrasound stimulation","volume":"66","author":"Zhang","year":"2019","journal-title":"IEEE Trans Biomed Eng"},{"key":"2022121707564689700_ref67","doi-asserted-by":"crossref","first-page":"3777","DOI":"10.1002\/hbm.22877","article-title":"Age-related changes in the topological organization of the white matter structural connectome across the human lifespan","volume":"36","author":"Zhao","year":"2015","journal-title":"Hum Brain Mapp"}],"container-title":["Cerebral Cortex"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cercor\/article-pdf\/33\/1\/235\/47909509\/bhac064.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cercor\/article-pdf\/33\/1\/235\/47909509\/bhac064.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,17]],"date-time":"2022-12-17T03:10:08Z","timestamp":1671246608000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cercor\/article\/33\/1\/235\/6551113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,21]]},"references-count":67,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,3,21]]},"published-print":{"date-parts":[[2022,12,15]]}},"URL":"https:\/\/doi.org\/10.1093\/cercor\/bhac064","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.11.19.469206","asserted-by":"object"}]},"ISSN":["1047-3211","1460-2199"],"issn-type":[{"value":"1047-3211","type":"print"},{"value":"1460-2199","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,1,1]]},"published":{"date-parts":[[2022,3,21]]}}}