{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:13:36Z","timestamp":1788347616803,"version":"build-2803163510"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,3,6]],"date-time":"2022-03-06T00:00:00Z","timestamp":1646524800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100004784","name":"Novartis Foundation for Medical-Biological Research","doi-asserted-by":"publisher","award":["17C195"],"award-info":[{"award-number":["17C195"]}],"id":[{"id":"10.13039\/501100004784","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Gottried and Julia Bangerter-Rhyner foundation","award":["20\/8472"],"award-info":[{"award-number":["20\/8472"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The role hemispheric lateralization in the prefrontal cortex plays for episodic memory formation in general, and for emotionally valenced information in particular, is debated. In a randomized, double-blind, and sham-controlled design, healthy young participants (n\u2009=\u2009254) performed 2 runs of encoding to categorize the perceptual, semantic, or emotionally valenced (positive or negative) features of words followed by a free recall and a recognition task. To resolve competing hypotheses about the contribution of each hemisphere, we modulated left or right dorsolateral prefrontal cortex (DLPFC) activity using transcranial direct current stimulation during encoding (1\u00a0mA, 20\u00a0min). With stimulation of the left DLPFC, but not the right DLPFC, encoding and free recall performance improved particularly for words that were processed semantically. In addition, enhancing left DLPFC activity increased memory formation for positive content while reducing that for negative content. In contrast, promoting right DLPFC activity increased memory formation for negative content. The left DLPFC assesses semantic properties of new memory content at encoding and thus influences how successful new episodic memories are established. Hemispheric laterlization\u2014more active left DLPFC and less active right DLPFC\u2014at the encoding stage shifts the formation of memory traces in favor of positively valenced content.<\/jats:p>","DOI":"10.1093\/cercor\/bhac088","type":"journal-article","created":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T12:08:49Z","timestamp":1644581329000},"page":"612-621","source":"Crossref","is-referenced-by-count":20,"title":["The left prefrontal cortex determines relevance at encoding and governs episodic memory formation"],"prefix":"10.1093","volume":"33","author":[{"given":"Michael","family":"Orth","sequence":"first","affiliation":[{"name":"University Hospital of Old Age Psychiatry and Psychotherapy, Bern University , 3000 Bern , Switzerland"},{"name":"Neurozentrum Siloah , 3073 G\u00fcmligen , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Wagnon","sequence":"additional","affiliation":[{"name":"University Hospital of Old Age 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