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However, the relation between FoG and pure locomotor control as well as its underlying mechanism remain unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 56 PD subjects were recruited and allocated to PD-FoG and PD-noFoG subgroups, and 34 age-matched heathy adults were included as heathy control (HC). Functional near-infrared spectroscopy was used to measure their prefrontal activation in a sitting lower-limb movement task, wherein subjects were asked to sit and tap their right toes as big and as fast as possible.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Result of one-way ANOVA (Group: PD-FoG vs. PD-noFoG vs. HC) revealed greater activation in the right prefrontal cortex in the PD-FoG group than in the other 2 groups. Linear mixed-effects model showed consistent result. Furthermore, the right prefrontal activation positively correlated with the severity of FoG symptoms in PD-FoG patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings suggested that PD patients with FoG require additional cognitive resources to compensate their damaged automaticity in locomotor control, which is more pronounced in severe FoG patients than milder ones.<\/jats:p><\/jats:sec>","DOI":"10.1093\/cercor\/bhac114","type":"journal-article","created":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T12:17:21Z","timestamp":1647605841000},"page":"959-968","source":"Crossref","is-referenced-by-count":8,"title":["Greater prefrontal activation during sitting toe tapping predicts severer freezing of gait in Parkinson\u2019s disease: an fNIRS study"],"prefix":"10.1093","volume":"33","author":[{"given":"Lanlan","family":"Pu","sequence":"first","affiliation":[{"name":"Department of Neurology , , Zhongshan Road, Dalian, Liaoning 116011 , 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