{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T16:07:15Z","timestamp":1777565235202,"version":"3.51.4"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,5,3]],"date-time":"2022-05-03T00:00:00Z","timestamp":1651536000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471372"],"award-info":[{"award-number":["81471372"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004761","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"crossref","award":["2019JJ40369"],"award-info":[{"award-number":["2019JJ40369"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004761","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"crossref","award":["2018JJ3635"],"award-info":[{"award-number":["2018JJ3635"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Hunan Graduate Scientific Research Innovation Project","award":["CX20190141"],"award-info":[{"award-number":["CX20190141"]}]},{"name":"Project of Graduate Independent Exploration and Innovation Plan of Central South University of China","award":["2019zzts085"],"award-info":[{"award-number":["2019zzts085"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,20]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Exposure therapy is the most effective approach of behavioral therapy for anxiety and post-traumatic stress disorder (PTSD). But fear is easy to reappear even after successful extinction. So, identifying novel strategies for augmenting exposure therapy is rather important. It was reported that exercise had beneficial effects on cognitive and memory deficits. However, whether exercise could affect fear memory, especially for fear extinction remained elusive. Here, our results showed that exposure to acute mild exercise 1 or 2\u00a0h before extinction training can augment recent fear extinction retention and 2\u00a0h for the remote fear extinction retention. These beneficial effects could be attributed to increased YTHDF1 expression in medial prefrontal cortex (mPFC). Furthermore, by using an AAV-shRNA-based approach to silence YTHDF1 expression via stereotactic injection in prelimbic cortex (PL) or infralimbic cortex (IL), respectively, we demonstrated that silence YTHDF1 in IL, but not in PL, blunted augmentation of exposure therapy induced by acute mild exercise and accompanied with decreased NR2B and GluR1 expression. Moreover, YTHDF1 modulated dendritic spines remodeling of pyramidal neuron in IL. Collectively, our findings suggested that acute mild exercise acted as an effective strategy in augmenting exposure therapy with possible implications for understanding new treatment underlying PTSD.<\/jats:p>","DOI":"10.1093\/cercor\/bhac174","type":"journal-article","created":{"date-parts":[[2022,4,16]],"date-time":"2022-04-16T11:07:34Z","timestamp":1650107254000},"page":"1814-1825","source":"Crossref","is-referenced-by-count":8,"title":["Infralimbic YTHDF1 is necessary for the beneficial effects of acute mild exercise on auditory fear extinction retention"],"prefix":"10.1093","volume":"33","author":[{"given":"Song-Ji","family":"Li","sequence":"first","affiliation":[{"name":"Department of Anatomy and Neurobiology , School of Basic Medical Science, , Changsha, Hunan Province 410013, China"},{"name":"Central South University , School of Basic Medical Science, , Changsha, Hunan Province 410013, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin-Xuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology , School of Basic Medical Science, , Changsha, Hunan Province 410013, China"},{"name":"Central South University , School of Basic Medical Science, , Changsha, Hunan Province 410013, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang-Jing","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology , School of Basic Medical Science, , Changsha, Hunan Province 410013, China"},{"name":"Central South University , School of Basic Medical Science, , Changsha, Hunan Province 410013, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min-Hui","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology , School of Basic Medical Science, , Changsha, Hunan Province 410013, China"},{"name":"Central South University , School of Basic Medical Science, , Changsha, Hunan Province 410013, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi-Fen","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology , School of Basic Medical Science, , Changsha, Hunan Province 410013, China"},{"name":"Central South University , School of Basic Medical Science, , Changsha, Hunan Province 410013, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Yu","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology , School of Basic Medical Science, , Changsha, Hunan Province 410013, China"},{"name":"Central South University , School of Basic Medical Science, , Changsha, Hunan Province 410013, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology , School of Basic Medical Science, , Changsha, Hunan Province 410013, China"},{"name":"Central South University , School of Basic Medical Science, , Changsha, Hunan Province 410013, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Qi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology , School of Basic Medical Science, , Changsha, Hunan Province 410013, China"},{"name":"Central South University , School of Basic Medical Science, , Changsha, Hunan Province 410013, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,5,3]]},"reference":[{"key":"2023030120391134400_","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.lfs.2016.02.016","article-title":"Anaerobic threshold employed on exercise training prescription and performance assessment for laboratory rodents: A short 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