{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T17:19:20Z","timestamp":1793812760250,"version":"4.6.1"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T00:00:00Z","timestamp":1652832000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["2625\/10-1"],"award-info":[{"award-number":["2625\/10-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["249425"],"award-info":[{"award-number":["249425"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Human Brain Project","award":["6 720270"],"award-info":[{"award-number":["6 720270"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>It is unknown whether impaired brain structure after congenital blindness is reversible if sight is restored later in life. Using structural magnetic resonance imaging, visual cortical surface area and cortical thickness were assessed in a large group of 21 sight-recovery individuals who had been born blind and who months or years later gained sight through cataract removal surgery. As control groups, we included 27 normally sighted individuals, 10 individuals with permanent congenital blindness, and 11 sight-recovery individuals with a late onset of cataracts. Congenital cataract-reversal individuals had a lower visual cortical surface area and a higher visual cortical thickness than normally sighted controls. These results corresponded to those of congenitally permanently blind individuals suggesting that impaired brain structure did not recover. Crucially, structural brain alterations in congenital-cataract reversal individuals were associated with a lower post-surgery visual acuity. No significant changes in visual cortex structure were observed in sight-recovery individuals with late onset cataracts. The results demonstrate that impaired structural brain development due to visual deprivation from birth is not fully reversible and limits functional recovery. Additionally, they highlight the crucial importance of prevention measures in the context of other types of aberrant childhood environments including low socioeconomic status and adversity.<\/jats:p>","DOI":"10.1093\/cercor\/bhac197","type":"journal-article","created":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T07:14:54Z","timestamp":1651734894000},"page":"2152-2161","source":"Crossref","is-referenced-by-count":25,"title":["Sight restoration in congenitally blind humans does not restore visual brain structure"],"prefix":"10.1093","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8626-5186","authenticated-orcid":false,"given":"Cordula","family":"H\u00f6lig","sequence":"first","affiliation":[{"name":"Biological Psychology and Neuropsychology , , 20146 Hamburg, Germany"},{"name":"University of Hamburg , , 20146 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria J S","family":"Guerreiro","sequence":"additional","affiliation":[{"name":"Biological Psychology and Neuropsychology , , 20146 Hamburg, Germany"},{"name":"University of Hamburg , , 20146 Hamburg, Germany"},{"name":"Biological Psychology , , 26111 Oldenburg, Germany"},{"name":"Carl von Ossietzky University of Oldenburg , , 26111 Oldenburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunitha","family":"Lingareddy","sequence":"additional","affiliation":[{"name":"Lucid Medical Diagnostics, Banjara Hills , 50034 Hyderabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramesh","family":"Kekunnaya","sequence":"additional","affiliation":[{"name":"Jasti V Ramanamma Children's Eye Care Center , , 50034 Hyderabad, India"},{"name":"Child Sight Institute, LV Prasad Eye Institute , , 50034 Hyderabad, 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