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The extent of this shift has been shown to relate to sound localization deficits. In this study, we examined whether cochlear implantation to treat postlingual AHL can restore the normal functional pattern of auditory cortical activity and whether this relates to improved sound localization. The auditory cortical activity was found to be lower in the AHL cochlear implanted (AHL-CI) participants. A cortical asymmetry index was calculated and showed that a normal contralateral dominance was restored in the AHL-CI patients for the nonimplanted ear, but not for the ear with the cochlear implant. It was found that the contralateral dominance for the nonimplanted ear strongly correlated with sound localization performance (rho\u2009=\u20090.8, P\u2009&amp;lt;\u20090.05). We conclude that the reorganization of binaural mechanisms in AHL-CI subjects reverses the abnormal lateralization pattern induced by the deafness, and that this leads to improved spatial hearing. Our results suggest that cochlear implantation enables the reconstruction of the cortical mechanisms of spatial selectivity needed for sound localization.<\/jats:p>","DOI":"10.1093\/cercor\/bhac204","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T17:23:45Z","timestamp":1654017825000},"page":"2229-2244","source":"Crossref","is-referenced-by-count":22,"title":["Auditory cortical plasticity after cochlear implantation in asymmetric hearing loss is related to spatial hearing: a PET H215O study"],"prefix":"10.1093","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4661-1731","authenticated-orcid":false,"given":"Chadlia","family":"Karoui","sequence":"first","affiliation":[{"name":"UMR 5549 , Facult\u00e9 de M\u00e9decine Purpan, Centre National de la Recherche Scientifique, Toulouse, France"},{"name":"Centre de Recherche Cerveau et Cognition , Universit\u00e9 de Toulouse, Universit\u00e9 Paul Sabatier, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6613-2300","authenticated-orcid":false,"given":"Kuzma","family":"Strelnikov","sequence":"additional","affiliation":[{"name":"UMR 5549 , Facult\u00e9 de M\u00e9decine Purpan, Centre National de la Recherche Scientifique, Toulouse, France"},{"name":"Centre de Recherche Cerveau et Cognition , Universit\u00e9 de Toulouse, Universit\u00e9 Paul Sabatier, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1374-1620","authenticated-orcid":false,"given":"Pierre","family":"Payoux","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Department , Purpan University Hospital, Toulouse, France"},{"name":"ToNIC , Toulouse NeuroImaging Center, Universit\u00e9 de Toulouse, Inserm, UPS, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4053-7158","authenticated-orcid":false,"given":"Anne-Sophie","family":"Salabert","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Department , Purpan University Hospital, Toulouse, France"},{"name":"ToNIC , Toulouse NeuroImaging Center, Universit\u00e9 de Toulouse, Inserm, UPS, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris J","family":"James","sequence":"additional","affiliation":[{"name":"Cochlear France SAS , Toulouse, France"},{"name":"Service d'Oto-Rhino-Laryngologie et Oto-Neurologie , CHU Toulouse France, Universit\u00e9 Toulouse 3, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4174-2580","authenticated-orcid":false,"given":"Olivier","family":"Deguine","sequence":"additional","affiliation":[{"name":"UMR 5549 , Facult\u00e9 de M\u00e9decine Purpan, Centre National de la Recherche Scientifique, Toulouse, France"},{"name":"Centre de Recherche Cerveau et Cognition , Universit\u00e9 de Toulouse, Universit\u00e9 Paul Sabatier, Toulouse, France"},{"name":"Service d'Oto-Rhino-Laryngologie et Oto-Neurologie , CHU Toulouse France, Universit\u00e9 Toulouse 3, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0125-7468","authenticated-orcid":false,"given":"Pascal","family":"Barone","sequence":"additional","affiliation":[{"name":"UMR 5549 , Facult\u00e9 de M\u00e9decine Purpan, Centre National de la Recherche Scientifique, Toulouse, France"},{"name":"Centre de Recherche Cerveau et Cognition , Universit\u00e9 de Toulouse, Universit\u00e9 Paul Sabatier, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8295-8885","authenticated-orcid":false,"given":"Mathieu","family":"Marx","sequence":"additional","affiliation":[{"name":"UMR 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