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From a hierarchical processing perspective, this paper proposed and tested a hypothesis that a domain-general network at the top of the WM hierarchy can interact with distinct domain-preferential intermediate circuits to support WM. Employing a novel N-back task, we first identified the posterior superior temporal gyrus (pSTG), middle temporal area (MT), and postcentral gyrus (PoCG) as intermediate regions for biological motion and shape motion processing, respectively. Using further psychophysiological interaction analyses, we delineated a frontal\u2013parietal network (FPN) as the domain-general network. These results were further verified and extended by a delayed match to sample (DMS) task. Although the WM load-dependent and stimulus-free activations during the DMS delay phase confirm the role of FPN as a domain-general network to maintain information, the stimulus-dependent activations within this network during the DMS encoding phase suggest its involvement in the final stage of the hierarchical processing chains. In contrast, the load-dependent activations of intermediate regions in the N-back task highlight their further roles beyond perception in WM tasks. These results provide empirical evidence for a hierarchical processing model of WM and may have significant implications for WM training.<\/jats:p>","DOI":"10.1093\/cercor\/bhac241","type":"journal-article","created":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T16:52:06Z","timestamp":1654620726000},"page":"2774-2787","source":"Crossref","is-referenced-by-count":12,"title":["A domain-general frontoparietal network interacts with domain-preferential intermediate pathways to support working memory task"],"prefix":"10.1093","volume":"33","author":[{"given":"Hui","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Psychology and Behavioral Science, Zhejiang University , 148 Tianmushan Road, Xihu District, Hangzhou, 310007 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conghui","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Psychology and Behavioral Science, Zhejiang University , 148 Tianmushan Road, Xihu 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