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Although brain abnormalities associated with apathy in clinical disorders have been studied, the organization of brain networks in healthy individuals has yet to be identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We examined properties of intrinsic brain networks in healthy individuals with varied levels of apathy. By using functional magnetic resonance imaging in combination with graph theory analysis and dynamic causal modeling analysis, we tested communications among nodes and modules as well as effective connectivity among brain networks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that the average participation coefficient of the subcortical network, especially the amygdala, was lower in individuals with high than low apathy. Importantly, we observed weaker effective connectivity fromthe hippocampus and parahippocampal gyrus to the amygdala, and from the amygdala to the parahippocampal gyrus and medial frontal cortex in individuals with apathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings suggest that individuals with high apathy exhibit aberrant communication within the cortical-to-subcortical network, characterized by differences in amygdala-related effective connectivity. Our work sheds light on the neural basis of apathy in subclinical populations and may have implications for understanding the development of clinical conditions that feature apathy.<\/jats:p><\/jats:sec>","DOI":"10.1093\/cercor\/bhac267","type":"journal-article","created":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T22:06:12Z","timestamp":1657836372000},"page":"3171-3180","source":"Crossref","is-referenced-by-count":5,"title":["Role of the amygdala in disrupted integration and effective connectivity of cortico-subcortical networks in apathy"],"prefix":"10.1093","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8916-5690","authenticated-orcid":false,"given":"Ningning","family":"Zeng","sequence":"first","affiliation":[{"name":"Shenzhen Key Laboratory of Affective and Social Neuroscience , Magnetic Resonance Imaging Center, Center for Brain Disorders and Cognitive Sciences, , Shenzhen 518060 , China"},{"name":"Shenzhen University , Magnetic Resonance Imaging Center, 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