{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T04:21:27Z","timestamp":1784866887298,"version":"3.55.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"6","funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01 MH60941"],"award-info":[{"award-number":["R01 MH60941"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Discovery grant from Natural Sciences and Engineering Research Council of Canada","award":["A8347"],"award-info":[{"award-number":["A8347"]}]},{"name":"Foundation Grant from Canadian Institutes of Health Research","award":["MOP-143311"],"award-info":[{"award-number":["MOP-143311"]}]},{"name":"Postdoctoral Fellowship Award from the Alzheimer\u2019s Society of Canada","award":["22-08"],"award-info":[{"award-number":["22-08"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Transcranial magnetic stimulation (TMS) delivered to the angular gyrus (AG) affects hippocampal function and associated behaviors (Thakral PP, Madore KP, Kalinowski SE, Schacter DL. Modulation of hippocampal brain networks produces changes in episodic simulation and divergent thinking. 2020a. Proc Natl Acad Sci U S A. 117:12729\u201312740). Here, we examine if functional magnetic resonance imaging (fMRI)-guided TMS disrupts the gradient organization of temporal signal properties, known as the temporal organization, in the hippocampus (HPC) and entorhinal cortex (ERC). For each of 2 TMS sessions, TMS was applied to either a control site (vertex) or to a left AG target region (N\u2009=\u200918; 14 females). Behavioral measures were then administered, and resting-state scans were acquired. Temporal dynamics were measured by tracking change in the fMRI signal (i) \u201cwithin\u201d single voxels over time, termed single-voxel autocorrelation and (ii) \u201cbetween\u201d different voxels over time, termed intervoxel similarity. TMS reduced AG connectivity with the hippocampal target and induced more rapid shifting of activity in single voxels between successive time points, lowering the single-voxel autocorrelation, within the left anteromedial HPC and posteromedial ERC. Intervoxel similarity was only marginally affected by TMS. Our findings suggest that hippocampal-targeted TMS disrupts the functional properties of the target site along the anterior\/posterior axis. Further studies should examine the consequences of altering the temporal dynamics of these medial temporal areas to the successful processing of episodic information under task demand.<\/jats:p>","DOI":"10.1093\/cercor\/bhac273","type":"journal-article","created":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T09:51:19Z","timestamp":1672134679000},"page":"3255-3264","source":"Crossref","is-referenced-by-count":15,"title":["Transcranial magnetic stimulation to the angular gyrus modulates the temporal dynamics of the hippocampus and entorhinal cortex"],"prefix":"10.1093","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1806-702X","authenticated-orcid":false,"given":"Gillian","family":"Coughlan","sequence":"first","affiliation":[{"name":"Rotman Research Institute, Baycrest Health Sciences , 3560 Bathurst St, North York, Ontario M6A 2E1, Canada"},{"name":"Harvard Medical School Department of Neurology, Massachusetts General Hospital, , 15 Parkman St, Boston, MA 02114, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nichole R","family":"Bouffard","sequence":"additional","affiliation":[{"name":"Rotman Research Institute, Baycrest Health Sciences , 3560 Bathurst St, North York, Ontario M6A 2E1, Canada"},{"name":"University of Toronto Department of Psychology, , 27 King's College Cir, Toronto, Ontario M5S 3G3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Golestani","sequence":"additional","affiliation":[{"name":"University of Toronto Department of Psychology, , 27 King's College Cir, Toronto, Ontario M5S 3G3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preston P","family":"Thakral","sequence":"additional","affiliation":[{"name":"Harvard University Department of Psychology, , 33 Kirkland St, Cambridge, MA 02138, United States"},{"name":"Boston College Department of Psychology and Neuroscience, , 140 Commonwealth Ave, Chestnut Hill, MA 02467, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel L","family":"Schacter","sequence":"additional","affiliation":[{"name":"Harvard University Department of Psychology, , 33 Kirkland St, Cambridge, MA 02138, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl","family":"Grady","sequence":"additional","affiliation":[{"name":"Rotman Research Institute, Baycrest Health Sciences , 3560 Bathurst St, North York, Ontario M6A 2E1, Canada"},{"name":"University of Toronto Department of Psychiatry, , 250 College Street, Toronto, Ontario M5T 1R8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morris","family":"Moscovitch","sequence":"additional","affiliation":[{"name":"Rotman Research Institute, Baycrest Health Sciences , 3560 Bathurst St, North York, Ontario M6A 2E1, Canada"},{"name":"University of Toronto Department of Psychology, , 27 King's College Cir, Toronto, Ontario M5S 3G3, 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