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Numerous studies have revealed abnormal brain activity associated with this disorder during episodic memory, however previous work has only relied on static analysis methods that treat the brain as a static monolithic structure, ignoring the dynamic features at different time scales. Here, we applied dynamic functional connectivity analysis to functional magnetic resonance imaging data during episodic memory and quantify integration and recruitment metrics to reveal abnormal dynamic reconfiguration of brain networks in SCZ. In the specific frequency band of 0.06\u20130.125\u00a0Hz, SCZ showed significantly higher integration during encoding and retrieval, and the abnormalities were mainly in the default mode, frontoparietal, and cingulo-opercular modules. Recruitment of SCZ was significantly higher during retrieval, mainly in the visual module. Interestingly, interactions between groups and task status in recruitment were found in the dorsal attention, visual modules. Finally, we observed that integration was significantly associated with memory performance in frontoparietal regions. Our findings revealed the time-varying evolution of brain networks in SCZ, while improving our understanding of cognitive decline and other pathophysiologies in brain diseases.<\/jats:p>","DOI":"10.1093\/cercor\/bhac331","type":"journal-article","created":{"date-parts":[[2022,8,28]],"date-time":"2022-08-28T06:48:28Z","timestamp":1661669308000},"page":"4135-4144","source":"Crossref","is-referenced-by-count":7,"title":["Abnormal dynamic reconfiguration of the large-scale functional network in schizophrenia during the episodic memory task"],"prefix":"10.1093","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7771-5360","authenticated-orcid":false,"given":"Bin","family":"Wang","sequence":"first","affiliation":[{"name":"Taiyuan University of Technology College of Information and Computer, , Taiyuan, 030024 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Pan","sequence":"additional","affiliation":[{"name":"Taiyuan University of 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