{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:14:12Z","timestamp":1790741652917,"version":"4.1.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T00:00:00Z","timestamp":1663632000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NHMRC Career Development Fellowship"},{"name":"NHMRC Career Development Fellowship","award":["1124472"],"award-info":[{"award-number":["1124472"]}]},{"name":"NHMRC Career Development Fellowship","award":["1061757"],"award-info":[{"award-number":["1061757"]}]},{"name":"National Health and Medical Research Council of Australia","award":["1064643"],"award-info":[{"award-number":["1064643"]}]},{"name":"National Health and Medical Research Council of Australia","award":["1024570"],"award-info":[{"award-number":["1024570"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Suppression of the brain\u2019s default mode network (DMN) during external goal-directed cognitive tasks has been consistently observed in neuroimaging studies. However, emerging insights suggest the DMN is not a monolithic \u201ctask-negative\u201d network but is comprised of subsystems that show functional heterogeneity. Despite considerable research interest, no study has investigated the consistency of DMN activity suppression across multiple cognitive tasks within the same individuals. In this study, 85 healthy 15- to 25-year-olds completed three functional magnetic resonance imaging tasks that were designed to reliably map DMN suppression from a resting baseline. Our findings revealed a distinct suppression subnetwork across the three tasks that comprised traditional DMN and adjacent regions. Specifically, common suppression was observed in the medial prefrontal cortex, the dorsal-to-mid posterior cingulate cortex extending to the precuneus, and the posterior insular cortex and parietal operculum. Further, we found the magnitude of suppression of these regions were significantly correlated within participants across tasks. Overall, our findings indicate that externally oriented cognitive tasks elicit common suppression of a distinct subnetwork of the broader DMN. The consistency to which the DMN is suppressed within individuals suggests a domain-general mechanism that may reflect a stable feature of cognitive function that optimizes external goal-directed behavior.<\/jats:p>","DOI":"10.1093\/cercor\/bhac361","type":"journal-article","created":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T02:48:05Z","timestamp":1661395685000},"page":"4553-4561","source":"Crossref","is-referenced-by-count":17,"title":["A distinct intra-individual suppression subnetwork in the brain\u2019s default mode network across cognitive tasks"],"prefix":"10.1093","volume":"33","author":[{"given":"Christine A","family":"Leonards","sequence":"first","affiliation":[{"name":"Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne , Parkville, Victoria, 3010 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben J","family":"Harrison","sequence":"additional","affiliation":[{"name":"Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne , Parkville, Victoria, 3010 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alec J","family":"Jamieson","sequence":"additional","affiliation":[{"name":"Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne , Parkville, Victoria, 3010 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor","family":"Steward","sequence":"additional","affiliation":[{"name":"Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne , Parkville, Victoria, 3010 , Australia"},{"name":"Melbourne School of Psychological Sciences, The University of Melbourne , Parkville, Victoria, 3010 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke","family":"Lux","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University of Bonn , Bonn, 53127 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Philipsen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University of Bonn , Bonn, 53127 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher G","family":"Davey","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, The University of Melbourne , Parkville, Victoria, 3010 , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,9,20]]},"reference":[{"issue":"4","key":"2023041801502920900_","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.neuron.2010.02.005","article-title":"Functional-anatomic fractionation of the brain\u2019s default network","volume":"65","author":"Andrews-Hanna","year":"2010","journal-title":"Neuron"},{"issue":"1","key":"2023041801502920900_","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1162\/089892999563265","article-title":"Conceptual processing during the conscious resting state: a functional MRI study","volume":"11","author":"Binder","year":"1999","journal-title":"J Cogn Neurosci"},{"issue":"10","key":"2023041801502920900_","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/s41583-019-0212-7","article-title":"The brain\u2019s default network: updated anatomy, physiology and evolving insights","volume":"20","author":"Buckner","year":"2019","journal-title":"Nat Rev Neurosci"},{"issue":"1","key":"2023041801502920900_","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1196\/annals.1440.011","article-title":"The brain\u2019s default network: anatomy, function, and relevance to disease","volume":"1124","author":"Buckner","year":"2008","journal-title":"Ann N Y Acad Sci"},{"issue":"1","key":"2023041801502920900_","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.neuroimage.2006.09.011","article-title":"Biological parametric mapping: a statistical toolbox for multimodality brain image analysis","volume":"34","author":"Casanova","year":"2007","journal-title":"NeuroImage"},{"issue":"4","key":"2023041801502920900_","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/S0959-4388(03)00090-4","article-title":"Interoception: the sense of the physiological condition of the body","volume":"13","author":"Craig","year":"2003","journal-title":"Curr Opin Neurobiol"},{"issue":"1","key":"2023041801502920900_","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nrn2555","article-title":"How do you feel \u2014 now? 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