{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T09:23:14Z","timestamp":1767864194613,"version":"3.49.0"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T00:00:00Z","timestamp":1663891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Scientific and Technological Innovation 2030","award":["2021ZD0204300"],"award-info":[{"award-number":["2021ZD0204300"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61827811"],"award-info":[{"award-number":["61827811"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","award":["F2022203050"],"award-info":[{"award-number":["F2022203050"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Low-intensity transcranial ultrasound stimulation (TUS) can modulate the coupling of high-frequency (160\u2013200\u00a0Hz) neural oscillations and cerebral blood oxygen metabolism (BOM); however, the correlation of low-frequency (0\u20132\u00a0Hz) neural oscillations with BOM in temporal and frequency domains under TUS remains unclear. To address this, we monitored the TUS-evoked neuronal calcium oscillations and BOM simultaneously in the mouse visual cortex by using multimodal optical imaging with a high spatiotemporal resolution. We demonstrated that TUS can significantly increase the intensity of the neuronal calcium oscillations and BOM; the peak value, peak time, and duration of calcium oscillations are functionally related to stimulation duration; TUS does not significantly increase the neurovascular coupling strength between calcium oscillations and BOM in the temporal domain; the time differences of the energy peaks between TUS-induced calcium oscillations and BOM depend on their spectral ranges; the frequency differences of the energy peaks between TUS-induced calcium oscillations and BOM depend on their time ranges; and TUS can significantly change the phase of calcium oscillations and BOM from uniform distribution to a more concentrated region. In conclusion, ultrasound stimulation can evoke the time\u2013frequency cross-coupling between the cortical low-frequency neuronal calcium oscillations and BOM in mouse.<\/jats:p>","DOI":"10.1093\/cercor\/bhac370","type":"journal-article","created":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T00:08:50Z","timestamp":1663891730000},"page":"4665-4676","source":"Crossref","is-referenced-by-count":9,"title":["Time\u2013frequency cross-coupling between cortical low-frequency neuronal calcium oscillations and blood oxygen metabolism evoked by ultrasound stimulation"],"prefix":"10.1093","volume":"33","author":[{"given":"Zhaocheng","family":"Su","sequence":"first","affiliation":[{"name":"Yanshan University School of Electrical Engineering, , Qinhuangdao 066004 , China"},{"name":"Yanshan University Key Laboratory of Intelligent Rehabilitation and Neuromodulation of Hebei Province, , Qinhuangdao 066004 , 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