{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T12:29:04Z","timestamp":1793449744578,"version":"4.5.0"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T00:00:00Z","timestamp":1666051200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"STEVIG, Oostrum, the Netherlands"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Triple X syndrome is a sex chromosomal aneuploidy characterized by the presence of a supernumerary X chromosome, resulting in a karyotype of 47,XXX in affected females. It has been associated with a variable cognitive, behavioral, and psychiatric phenotype, but little is known about its effects on brain function. We therefore conducted 7\u00a0T resting-state functional magnetic resonance imaging and compared data of 19 adult individuals with 47,XXX and 21 age-matched healthy control women using independent component analysis and dual regression. Additionally, we examined potential relationships between social cognition and social functioning scores, and IQ, and mean functional connectivity values. The 47,XXX group showed significantly increased functional connectivity of the fronto-parietal resting-state network with the right postcentral gyrus. Resting-state functional connectivity (rsFC) variability was not associated with IQ and social cognition and social functioning deficits in the participants with 47,XXX. We thus observed an effect of a supernumerary X chromosome in adult women on fronto-parietal rsFC. These findings provide additional insight into the role of the X chromosome on functional connectivity of the brain. Further research is needed to understand the clinical implications of altered rsFC in 47,XXX.<\/jats:p>","DOI":"10.1093\/cercor\/bhac410","type":"journal-article","created":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T14:08:51Z","timestamp":1666102131000},"page":"5210-5217","source":"Crossref","is-referenced-by-count":4,"title":["Resting-state functional connectivity in adults with 47,XXX: a 7 Tesla MRI study"],"prefix":"10.1093","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5310-6859","authenticated-orcid":false,"given":"Chaira","family":"Serrarens","sequence":"first","affiliation":[{"name":"Maastricht University Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, , Maastricht, 6200 MD , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sriranga","family":"Kashyap","sequence":"additional","affiliation":[{"name":"Maastricht University Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, , Maastricht, 6229 EV , The Netherlands"},{"name":"University Health Network Techna Institute, , Toronto, M5G 2C4 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Riveiro-Lago","sequence":"additional","affiliation":[{"name":"Maastricht University Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, , Maastricht, 6200 MD , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten","family":"Otter","sequence":"additional","affiliation":[{"name":"Maastricht University Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, , Maastricht, 6200 MD , The Netherlands"},{"name":"Medical Department, SIZA , Arnhem, 6800 AM , The Netherlands"},{"name":"Trajectum Department of Community Mental Health in Mild Intellectual Disabilities, , Zutphen, 7202 AG , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bea C M","family":"Campforts","sequence":"additional","affiliation":[{"name":"Maastricht University Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, , Maastricht, 6200 MD , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constance T R M","family":"Stumpel","sequence":"additional","affiliation":[{"name":"Maastricht University Medical Centre Department of Clinical Genetics and School for Oncology and Developmental Biology, , Maastricht, 6229 ER , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henk","family":"Jansma","sequence":"additional","affiliation":[{"name":"Maastricht University Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, , Maastricht, 6229 EV , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E 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