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However, the genetic mechanisms underlying structural and functional changes remain largely unknown. Based on the structural and resting-state functional magnetic resonance imaging data of 22 drug-na\u00efve children with BECTS and 33 healthy controls, we conducted voxel-based morphology (VBM) and fractional amplitude of low-frequency fluctuation (fALFF) analyses to compare cortical morphology and spontaneous brain activity between the 2 groups. In combination with the Allen Human Brain Atlas, transcriptome-neuroimaging spatial correlation analyses were applied to explore gene expression profiles associated with gray matter volume (GMV) and fALFF changes in BECTS. VBM analysis demonstrated significantly increased GMV in the right brainstem and right middle cingulate gyrus in BECTS. Moreover, children with BECTS exhibited significantly increased fALFF in left temporal pole, while decreased fALFF in right thalamus and left precuneus. These brain structural and functional alterations were closely related to behavioral and cognitive deficits, and the fALFF-linked gene expression profiles were enriched in voltage-gated ion channel and synaptic activity as well as neuron projection. Our findings suggest that brain morphological and functional abnormalities in children with BECTS involve complex polygenic genetic mechanisms.<\/jats:p>","DOI":"10.1093\/cercor\/bhac458","type":"journal-article","created":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T10:00:26Z","timestamp":1669716026000},"page":"5774-5782","source":"Crossref","is-referenced-by-count":13,"title":["Structural and functional changes in drug-na\u00efve benign childhood epilepsy with centrotemporal spikes and their associated gene expression profiles"],"prefix":"10.1093","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8346-262X","authenticated-orcid":false,"given":"Yu","family":"Yin","sequence":"first","affiliation":[{"name":"Department of Radiology, Affiliated Hospital of Zunyi Medical University, Medical Imaging Center of Guizhou Province , Zunyi 563003 , 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