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However, it is still unclear whether the same configurations would occur in gray matter (GM) graphs. Structural MRI was performed on 49 patients with SAD and on 51 age- and gender-matched healthy controls (HC). Single-subject GM networks were obtained based on the areal similarities of GM, and network topological properties were analyzed using graph theory. Group differences in each topological metric were compared, and the structure\u2013function coupling was examined. These network measures were further correlated with the clinical characteristics in the SAD group. Compared with controls, the SAD patients demonstrated globally decreased clustering coefficient and characteristic path length. Altered topological properties were found in the fronto-limbic and sensory processing systems. Altered metrics were associated with the illness duration of SAD. Compared with the HC group, the SAD group exhibited significantly decreased structural\u2013functional decoupling. Furthermore, structural\u2013functional decoupling was negatively correlated with the symptom severity in SAD. These findings highlight less-optimized topological configuration of the brain structural networks in SAD, which may provide insights into the neural mechanisms underlying the excessive fear and avoidance of social interactions in SAD.<\/jats:p>","DOI":"10.1093\/cercor\/bhac498","type":"journal-article","created":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T16:42:43Z","timestamp":1671813763000},"page":"3311-3317","source":"Crossref","is-referenced-by-count":3,"title":["Altered single-subject gray matter structural networks in social anxiety disorder"],"prefix":"10.1093","volume":"33","author":[{"given":"Ying","family":"Chen","sequence":"first","affiliation":[{"name":"West China Hospital of Sichuan University Huaxi MR Research Center (HMRRC), Department of Radiology, , Chengdu 640041 , China"},{"name":"Chinese Academy of Medical Sciences Research Unit of Psychoradiology, , Chengdu, Sichuan 640041 , 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