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However, the underlying disrupted brain connectome and the neural basis remain unclear. In our current study, 38 first-episode, treatment-naive patients with DMD and 22 matched healthy controls (HC) were enrolled and received resting-sate functional magnetic resonance imaging scans. Voxel-based degree centrality (DC), seed-based functional connectivity (FC), and clinical correlation were performed. Relative to HC, DMD patients had lower height, full Intellectual Quotients (IQ), and IQ-verbal comprehension. Significant increment of DC of DMD patients were found in the left dorsolateral prefrontal cortex (DLPFC.L) and right dorsomedial prefrontal cortex (DMPFC.R), while decreased DC were found in right cerebellum posterior lobe (CPL.R), right precentral\/postcentral gyrus (Pre\/Postcentral G.R). DMD patients had stronger FC in CPL.R-bilateral lingual gyrus, Pre\/Postcentral G.R-Insular, and DMPFC.R-Precuneus.R, had attenuated FC in DLPFC.L-Insular. These abnormally functional couplings were closely associated with the extent of cognitive impairment, suggested an over-activation of default mode network and executive control network, and a suppression of primary sensorimotor cortex and cerebellum-visual circuit. The findings collectively suggest the distributed brain connectome disturbances maybe a neuroimaging biomarker in DMD patients with mild cognitive impairment.<\/jats:p>","DOI":"10.1093\/cercor\/bhac542","type":"journal-article","created":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T16:07:48Z","timestamp":1672675668000},"page":"6785-6791","source":"Crossref","is-referenced-by-count":19,"title":["Connectomic disturbances in Duchenne muscular dystrophy with mild cognitive impairment"],"prefix":"10.1093","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9923-5509","authenticated-orcid":false,"given":"Bochao","family":"Cheng","sequence":"first","affiliation":[{"name":"West China Second University Hospital, Sichuan University Department of Radiology, , South Renmin Road, Wuhou District, Chengdu, 610041 , China"},{"name":"Huaxi MR Research Center (HMRRC), West China Hospital of Sichuan University Department of Radiology, , Guoxue Street, Wuhou District, Chengdu, 610041 , 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejing","family":"Ma","sequence":"additional","affiliation":[{"name":"The First People's Hospital of Zunyi, Zunyi Medical University Department of Radiology, , Fenghuang Road, Huichuan District, Zunyi, 563099 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotang","family":"Cai","sequence":"additional","affiliation":[{"name":"West China Second University Hospital, Sichuan University Department of Rehabilitation Medicine, , South Renmin Road, Wuhou District, Chengdu, 610041 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingkun","family":"Guo","sequence":"additional","affiliation":[{"name":"West China Second University Hospital, Sichuan University Department of Radiology, , South Renmin Road, Wuhou District, Chengdu, 610041 , China"},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education , 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