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These interactions may differ across disease subtypes and provide a novel biomarker for diagnosis and treatment. Using a network mapping algorithm based on resting-state functional MRI (rs-fMRI), a method that is readily implemented on conventional MRI scanners, we identified similar disease topographies in hereditary dystonia associated with the DYT1 or DYT6 mutations and in sporadic patients lacking these mutations. Both networks were characterized by contributions from the basal ganglia, cerebellum, thalamus, sensorimotor areas, as well as cortical association regions. Expression levels for the two networks were elevated in hereditary and sporadic dystonia, and in non-manifesting carriers of dystonia mutations. Nonetheless, the distribution of abnormal functional connections differed across groups, as did metrics of network organization and efficiency in key modules. Despite these differences, network expression correlated with dystonia motor ratings, significantly improving the accuracy of predictions based on thalamocortical tract integrity obtained with diffusion tensor MRI (DTI). Thus, in addition to providing unique information regarding the anatomy of abnormal brain circuits, rs-fMRI functional networks may provide a widely accessible method to help in the objective evaluation of new treatments for this disorder.<\/jats:p>","DOI":"10.1093\/cercor\/bhad012","type":"journal-article","created":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T23:25:56Z","timestamp":1673479556000},"page":"6943-6958","source":"Crossref","is-referenced-by-count":15,"title":["Disordered network structure and function in dystonia: pathological connectivity vs. adaptive responses"],"prefix":"10.1093","volume":"33","author":[{"given":"An","family":"Vo","sequence":"first","affiliation":[{"name":"Center for Neurosciences, The Feinstein Institutes for Medical Research , Manhasset, NY 11030 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nha","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Genetics, Albert Einstein College of 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