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Steep discounting of delayed outcome is related to a variety of maladaptive behaviors and is considered as a transdiagnostic process across psychiatric disorders. Previous studies have investigated the association between brain structure (e.g. gray matter volume) and DD; however, it is unclear whether the intracortical myelin (ICM) influences DD. Here, based on a sample of 951 healthy young adults drawn from the Human Connectome Project, we examined the relationship between ICM, which was measured by the contrast of T1w and T2w images, and DD and further tested whether the identified associations were mediated by the regional homogeneity (ReHo) of brain spontaneous activity. Vertex-wise regression analyses revealed that steeper DD was significantly associated with lower ICM in the left temporoparietal junction (TPJ) and right middle-posterior cingulate cortex. Region-of-interest analysis revealed that the ReHo values in the left TPJ partially mediated the association of its myelin content with DD. Our findings provide the first evidence that cortical myelination is linked with individual differences in decision impulsivity and suggest that the myelin content affects cognitive performances partially through altered local brain synchrony.<\/jats:p>","DOI":"10.1093\/cercor\/bhad028","type":"journal-article","created":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T19:38:10Z","timestamp":1675798690000},"page":"7163-7174","source":"Crossref","is-referenced-by-count":4,"title":["The intracortical myelin content of impulsive choices: results from T1- and T2-weighted MRI myelin mapping"],"prefix":"10.1093","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3167-6348","authenticated-orcid":false,"given":"Yiqun","family":"Guo","sequence":"first","affiliation":[{"name":"School of Innovation and Entrepreneurship education, Chongqing University of Posts and Telecommunications , Chongqing , China"},{"name":"Research Center of Biomedical Engineering, Chongqing University of Posts and Telecommunications , Chongqing , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debo","family":"Dong","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cognition and Personality, Ministry of Education , Chongqing , China"},{"name":"Faculty of Psychology, Southwest University , Chongqing , China"},{"name":"Institute of Neuroscience and Medicine (INM-7: Brain and Behaviour), Research Centre J\u00fclich , J\u00fclich , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huimin","family":"Wu","sequence":"additional","affiliation":[{"name":"Faculty of Psychology, Southwest University , Chongqing , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyuan","family":"Xue","sequence":"additional","affiliation":[{"name":"School of Humanities and Management, Heilongjiang University of Chinese Medicine , Harbin , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Faculty of Psychology, Southwest University , Chongqing , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le","family":"Zhao","sequence":"additional","affiliation":[{"name":"Faculty of Psychology, Beijing Normal University , Zhuhai , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhangyong","family":"Li","sequence":"additional","affiliation":[{"name":"Research Center of Biomedical Engineering, Chongqing University of Posts and Telecommunications , Chongqing , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingyong","family":"Feng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cognition and Personality, Ministry of Education , Chongqing , China"},{"name":"Faculty of Psychology, Southwest University , Chongqing , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,2,7]]},"reference":[{"key":"2023081212465973700_ref1","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.brainres.2008.07.084","article-title":"Thinking about the future versus the past in personal and non-personal contexts","volume":"1233","author":"Abraham","year":"2008","journal-title":"Brain Res"},{"issue":"3","key":"2023081212465973700_ref2","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0376-6357(03)00150-5","article-title":"Pathological gambling severity is associated with impulsivity in a delay discounting procedure","volume":"64","author":"Alessi","year":"2003","journal-title":"Behav Process"},{"issue":"2","key":"2023081212465973700_ref3","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1007\/s00429-013-0698-0","article-title":"Definition and characterization of an extended social-affective default network","volume":"220","author":"Amft","year":"2015","journal-title":"Brain Struct Funct"},{"issue":"4","key":"2023081212465973700_ref4","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1111\/j.1530-0277.2011.01656.x","article-title":"Is talk \u201ccheap\u201d? 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