{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T09:07:44Z","timestamp":1747300064414,"version":"3.37.3"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2023,3,4]],"date-time":"2023-03-04T00:00:00Z","timestamp":1677888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Independent Investigator Award"},{"DOI":"10.13039\/100000874","name":"Brain and Behavior Research Foundation","doi-asserted-by":"publisher","award":["22200"],"award-info":[{"award-number":["22200"]}],"id":[{"id":"10.13039\/100000874","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Alternative Funding Plan Innovations Award"},{"name":"Department of Psychiatry and Behavioral Neurosciences"},{"DOI":"10.13039\/100009776","name":"McMaster University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009776","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Canadian Institutes for Health Research Frederick Banting and Charles Best Canada Graduate Scholarships Doctoral Award"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Age-related changes of intracortical myelin in bipolar disorder (BD) have been observed to deviate from the quadratic age curve observed in healthy controls (HC), but it is unclear if this holds at varying cortical depths. From BD (n\u2009=\u200944; age range\u2009=\u200917.6\u201345.5\u00a0years) and HC (n\u2009=\u200960; age range\u2009=\u200917.1\u201345.8\u00a0years) participants, we collected 3T T1-weighted (T1w) images with strong intracortical contrast. Signal values were sampled from 3 equivolume cortical depths. Linear mixed models were used to compare age-related changes in the T1w signal between depths and between groups at each depth. In HC, the age-related changes were significantly different between the superficial one-fourth depth and the deeper depths in the right ventral somatosensory (t\u2009=\u2009\u22124.63; FDRp\u2009=\u20090.00025), left dorsomedial somatosensory (t\u2009=\u2009\u22123.16; FDRp\u2009=\u20090.028), left rostral ventral premotor (t\u2009=\u2009\u22123.16; FDRp\u2009=\u20090.028), and right ventral inferior parietal cortex (t\u2009=\u2009\u22123.29; FDRp\u2009=\u20090.028). BD participants exhibited no differences in the age-related T1w signal between depths. Illness duration was negatively correlated with the T1w signal at the one-fourth depth in the right anterior cingulate cortex (rACC; rho\u2009=\u2009\u22120.50; FDRp =\u20090.029). Physiological age-related and depth-specific variation in the T1w signal were not observed in BD. The T1w signal in the rACC may reflect lifetime disease burden in the disorder.<\/jats:p>","DOI":"10.1093\/cercor\/bhad052","type":"journal-article","created":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T05:24:46Z","timestamp":1678166686000},"page":"7468-7476","source":"Crossref","is-referenced-by-count":2,"title":["Loss of age-related laminar differentiation of intracortical myelin in bipolar disorder"],"prefix":"10.1093","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7428-6628","authenticated-orcid":false,"given":"Jee Su","family":"Suh","sequence":"first","affiliation":[{"name":"Mood Disorders Program, St. Joseph\u2019s Healthcare Hamilton , 100 West 5th Street, Hamilton, Ontario L8N 3K7 , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9107-6972","authenticated-orcid":false,"given":"Christopher D","family":"Rowley","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University , 3801 University Street, Montreal, Quebec, H3A 2B4 , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manpreet","family":"Sehmbi","sequence":"additional","affiliation":[{"name":"Mood Disorders Program, St. Joseph\u2019s Healthcare Hamilton , 100 West 5th Street, Hamilton, Ontario L8N 3K7 , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8356-6808","authenticated-orcid":false,"given":"Christine L","family":"Tardif","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University , 3801 University Street, Montreal, Quebec, H3A 2B4 , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7532-1851","authenticated-orcid":false,"given":"Luciano","family":"Minuzzi","sequence":"additional","affiliation":[{"name":"Mood Disorders Program, St. Joseph\u2019s Healthcare Hamilton , 100 West 5th Street, Hamilton, Ontario L8N 3K7 , Canada"},{"name":"Department of Psychiatry and Behavioural Neurosciences, McMaster University , 100 West 5th Street, Hamilton, Ontario, L8N 3K7 , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas A","family":"Bock","sequence":"additional","affiliation":[{"name":"Department of Psychology , Neuroscience and Behaviour, , 1280 Main Street West, Hamilton, Ontario, L8S 4K1 , Canada"},{"name":"McMaster University , Neuroscience and Behaviour, , 1280 Main Street West, Hamilton, Ontario, L8S 4K1 , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8267-943X","authenticated-orcid":false,"given":"Benicio N","family":"Frey","sequence":"additional","affiliation":[{"name":"Mood Disorders Program, St. Joseph\u2019s Healthcare Hamilton , 100 West 5th Street, Hamilton, Ontario L8N 3K7 , Canada"},{"name":"Department of Psychiatry and Behavioural Neurosciences, McMaster University , 100 West 5th Street, Hamilton, Ontario, L8N 3K7 , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,3,4]]},"reference":[{"issue":"4","key":"2023061506405781700_ref1","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1002\/hbm.23121","article-title":"MarsAtlas: a cortical parcellation atlas for functional mapping","volume":"37","author":"Auzias","year":"2016","journal-title":"Hum Brain Mapp"},{"issue":"9 Supplement","key":"2023061506405781700_ref2","doi-asserted-by":"crossref","first-page":"S364","DOI":"10.1016\/j.biopsych.2021.02.907","article-title":"Aberrant levels of cortical myelin distinguish individuals with unipolar depression from healthy controls","volume":"89","author":"Baranger","year":"2021","journal-title":"Biol 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