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The present study examined the LGI alterations in first-episode antipsychotic-naive schizophrenia compared with controls (235 patients and 214 controls); transcription-neuroimaging association analysis was used to evaluate the relationship between LGI deficits and specific risk genes. The expression profiles of 232 schizophrenia risk genes were extracted from six donated normal brains from the Allen Human Brain Atlas database. The correlation between LGI alterations and clinical symptoms was also tested. We found lower LGI values involved in frontotemporal regions and limbic systems. Nonparametric correlation analysis showed that 83 risk genes correlated with the hypogyrification pattern in schizophrenia. These identified risk genes were functionally enriched for the development of the central nervous system. The LGI in the left superior temporal gyrus was negatively associated with Positive and Negative Syndrome Scale negative symptoms. In summary, the present study provides a set of risk genes possibly related to the hypogyrification pattern in antipsychotic-naive first-episode schizophrenia, which could help to unveil the neurobiological underpinnings of cortical impairments in early-stage schizophrenia.<\/jats:p>","DOI":"10.1093\/cercor\/bhad065","type":"journal-article","created":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T13:58:26Z","timestamp":1678802306000},"page":"7619-7626","source":"Crossref","is-referenced-by-count":11,"title":["The cortical hypogyrification pattern in antipsychotic-naive first-episode schizophrenia"],"prefix":"10.1093","volume":"33","author":[{"given":"Xin","family":"Gao","sequence":"first","affiliation":[{"name":"Huaxi MR Research Center (HMRRC) , Department of Radiology, , Chengdu, Sichuan 610041 , China"},{"name":"West China Hospital of Sichuan University , Department of Radiology, , Chengdu, Sichuan 610041 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Yao","sequence":"additional","affiliation":[{"name":"Huaxi MR Research Center (HMRRC) , Department of Radiology, , Chengdu, Sichuan 610041 , China"},{"name":"West China Hospital of Sichuan University , Department of Radiology, , Chengdu, Sichuan 610041 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4737-5710","authenticated-orcid":false,"given":"Fei","family":"Li","sequence":"additional","affiliation":[{"name":"Huaxi MR Research Center (HMRRC) , Department of Radiology, , Chengdu, Sichuan 610041 , China"},{"name":"West China Hospital of Sichuan University , Department of Radiology, , Chengdu, Sichuan 610041 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengmin","family":"Yang","sequence":"additional","affiliation":[{"name":"Huaxi MR Research Center (HMRRC) , Department of Radiology, , Chengdu, Sichuan 610041 , 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