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Microgravity effects are well-replicated in head-down tilt bed rest (HDBR). Artificial gravity (AG) is a potential countermeasure to mitigate the effects of microgravity on human physiology and performance. We examined the effectiveness of daily AG for mitigating brain and\/or behavioral changes in 60\u00a0days of HDBR. One group received AG for 30\u00a0minutes daily (AG; n\u2009=\u200916) and a control group spent the same time in HDBR but received no AG (CTRL; n\u2009=\u20098). All participants performed a sensorimotor adaptation task five times during fMRI scanning: twice prior to HDBR, twice during HDBR, and once following HDBR. The AG group showed similar behavioral adaptation effects compared with the CTRLs. We identified decreased brain activation in the AG group from pre to late HDBR in the cerebellum for the task baseline portion and in the thalamus, calcarine, cuneus, premotor cortices, and superior frontal gyrus in the AG group during the early adaptation phase. The two groups also exhibited differential brain-behavior correlations. Together, these results suggest that AG may result in a reduced recruitment of brain activity for basic motor processes and sensorimotor adaptation. These effects may stem from the somatosensory and vestibular stimulation that occur with AG.<\/jats:p>","DOI":"10.1093\/cercor\/bhad094","type":"journal-article","created":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T14:08:39Z","timestamp":1678802919000},"page":"8011-8023","source":"Crossref","is-referenced-by-count":10,"title":["Daily artificial gravity is associated with greater neural efficiency during sensorimotor adaptation"],"prefix":"10.1093","volume":"33","author":[{"given":"Grant D","family":"Tays","sequence":"first","affiliation":[{"name":"Department of Applied Physiology and Kinesiology, University of Florida , Gainesville, FL 32603 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen E","family":"Hupfeld","sequence":"additional","affiliation":[{"name":"Department of Applied Physiology and Kinesiology, University of Florida , Gainesville, FL 32603 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather 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