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In this study, we estimated and compared the gray matter volume of the LC and its structural covariance (SC) with the whole brain among 161 normal healthy controls (HCs), 99 individuals with significant memory concern (SMC) and 131 patients with mild cognitive impairment (MCI). We found that SC decreased in MCI groups, which mainly involved the salience network and default mode network. These results imply that seeding from LC, the gray matter network disruption and disconnection appears early in the MCI group. The altered SC network seeding from the LC can serve as an imaging biomarker for discriminating the patients in the potential predementia phase of AD from the normal subjects.<\/jats:p>","DOI":"10.1093\/cercor\/bhad137","type":"journal-article","created":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T02:49:57Z","timestamp":1683082197000},"page":"8523-8533","source":"Crossref","is-referenced-by-count":13,"title":["Altered structural covariance of locus coeruleus in individuals with significant memory concern and patients with mild cognitive impairment"],"prefix":"10.1093","volume":"33","author":[{"given":"Yingmei","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University , No.107 Yanjiang Road West, Guangzhou 510120, Guangdong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghui","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University , No.107 Yanjiang Road West, Guangzhou 510120, Guangdong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunhua","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University , No.107 Yanjiang Road West, Guangzhou 510120, Guangdong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Psychology, Key Laboratory of Brain, Cognition and Education Sciences (South China Normal University), Ministry of Education, Center for Studies of Psychological Application, and Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University , No.55 Zhongshan Avenue West, Guangzhou 510631, Guangdong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Psychology, Key Laboratory of Brain, Cognition and Education Sciences (South China Normal University), Ministry of Education, Center for Studies of Psychological Application, and Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University , No.55 Zhongshan Avenue West, Guangzhou 510631, Guangdong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiwei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University , No.107 Yanjiang Road West, Guangzhou 510120, Guangdong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Alzheimer\u2019s Disease Neuroimaging 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