{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T16:05:21Z","timestamp":1785945921954,"version":"3.56.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"15","license":[{"start":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T00:00:00Z","timestamp":1686009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["RO1NS111029"],"award-info":[{"award-number":["RO1NS111029"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["T32GM136651"],"award-info":[{"award-number":["T32GM136651"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["F30HD106694"],"award-info":[{"award-number":["F30HD106694"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Hydrocephalus is classically considered to be a disorder of altered cerebrospinal fluid (CSF) circulation, leading to the dilation of cerebral ventricles. Here, we report a clinical case of a patient who presented with fetal-onset hydrocephalus with diffusely reduced cortical and white matter volumes resulting from a genetic mutation in L1CAM, a well-known hydrocephalus disease gene involved in neuronal cell adhesion and axon development. After CSF was drained from the ventricle intraoperatively, the patient\u2019s cortical mantle collapsed and exhibited a \u201cfloppy\u201d appearance on neuroimaging, suggesting an inability of the hydrocephalic brain to maintain its structural integrity. The case provides clinical support for altered brain biomechanical properties in human hydrocephalus and adds to the emerging hypothesis that altered brain development with secondary impact on brain structural stability may contribute to ventricular enlargement in some subsets of hydrocephalus.<\/jats:p>","DOI":"10.1093\/cercor\/bhad206","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T13:54:05Z","timestamp":1686318845000},"page":"9339-9342","source":"Crossref","is-referenced-by-count":5,"title":["\u201cFloppy brain\u201d in congenital hydrocephalus"],"prefix":"10.1093","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4513-7348","authenticated-orcid":false,"given":"Phan Q","family":"Duy","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Yale University School of Medicine , New Haven, CT 06510 , United States"},{"name":"Medical Scientist Training Program, Yale University School of Medicine , New Haven, CT 06510 , United States"},{"name":"Department of Neurosurgery, Yale University School of Medicine , New Haven, CT 06510 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5922-7547","authenticated-orcid":false,"given":"Kristopher T","family":"Kahle","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Massachusetts General Hospital , Boston, MA 02114 , United States"},{"name":"Broad Institute of MIT and Harvard , Cambridge, MA 02142 , United States"},{"name":"Harvard Center for Hydrocephalus and Neurodevelopmental Disorders, Massachusetts General Hospital , Boston, MA 02114 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,6,6]]},"reference":[{"issue":"10","key":"2023080122592698900_ref1","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1002\/acn3.51448","article-title":"L1CAM variants cause two distinct imaging phenotypes on 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