{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T16:59:32Z","timestamp":1773248372429,"version":"3.50.1"},"reference-count":102,"publisher":"Oxford University Press (OUP)","issue":"15","license":[{"start":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T00:00:00Z","timestamp":1686096000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"publisher","award":["2020HXBH092"],"award-info":[{"award-number":["2020HXBH092"]}],"id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018525","name":"Key Research and Development Program of Sichuan Province","doi-asserted-by":"publisher","award":["2023YFS0084"],"award-info":[{"award-number":["2023YFS0084"]}],"id":[{"id":"10.13039\/501100018525","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"publisher","award":["2022YFC2009900"],"award-info":[{"award-number":["2022YFC2009900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82027808"],"award-info":[{"award-number":["82027808"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81820108018"],"award-info":[{"award-number":["81820108018"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81761128023"],"award-info":[{"award-number":["81761128023"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81621003"],"award-info":[{"award-number":["81621003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31800963"],"award-info":[{"award-number":["31800963"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The COVID-19 pandemic has been increasingly documented to cause negative impacts on mental health outcomes, e.g. posttraumatic stress symptoms (PTSS). Dispositional optimism (\u201coptimism\u201d hereinafter), a crucial psychological characteristic defined by positive expectancies for future outcomes, is considered to provide remarkable protection against PTSS. Accordingly, this study was designed to identify neuroanatomical signatures of optimism and further examine the mechanism through which optimism protects against COVID-19-specific PTSS. Here, 115 volunteers from a general population of university students completed MRI scans and optimism tests before (October 2019\u2013January 2020) and after (February\u2013April 2020) the onset of the COVID-19 pandemic. Whole-brain voxel-based morphometry analysis showed that a region from the dorsal anterior cingulate cortex (dACC) to the dorsomedial prefrontal cortex (dmPFC) was associated with optimism. Further seed-based structural covariance network (SCN) analysis using partial least-squares correlation found an optimism-linked SCN covarying with the combined dACC and dmPFC (the dACC-dmPFC). Additionally, mediation analyses revealed that the dACC-dmPFC volume and its SCN impacted COVID-19-specific PTSS through optimism. Our findings deepen the understanding of optimism and have the potential to identify vulnerable individuals during the COVID-19 pandemic or similar future events, as well as to guide optimism-related neural interventions to prevent and alleviate PTSS.<\/jats:p>","DOI":"10.1093\/cercor\/bhad211","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T07:58:33Z","timestamp":1686211113000},"page":"9387-9398","source":"Crossref","is-referenced-by-count":21,"title":["Neuroanatomical signatures associated with dispositional optimism predict COVID-19-related posttraumatic stress symptoms"],"prefix":"10.1093","volume":"33","author":[{"given":"Han","family":"Lai","sequence":"first","affiliation":[{"name":"Department of Radiology and Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital , Sichuan University, Chengdu 610041 , China"},{"name":"Army Medical University Department of Medical Psychology, , Chongqing 400038 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yajun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Southwest Minzu University School of Education and Psychology, , Chengdu 610041 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingguang","family":"Li","sequence":"additional","affiliation":[{"name":"Dali University College of Education, , Dali 671000 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiyong","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Radiology and Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital, Sichuan University , Chengdu 610041 , China"},{"name":"West China Xiamen Hospital of Sichuan University Department of Radiology, , Xiamen 361000 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology and Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital, Sichuan University , Chengdu 610041 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,6,7]]},"reference":[{"issue":"10","key":"2023080122591340400_ref1","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1038\/s41593-021-00902-9","article-title":"Probing neural codes with two-photon holographic optogenetics","volume":"24","author":"Adesnik","year":"2021","journal-title":"Nat Neurosci"},{"issue":"6","key":"2023080122591340400_ref2","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1037\/0278-6133.19.6.586","article-title":"Relationship of subjective and objective social status with psychological and physiological 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