{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:01:59Z","timestamp":1787169719187,"version":"build-2736575974"},"reference-count":106,"publisher":"Oxford University Press (OUP)","issue":"17","license":[{"start":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T00:00:00Z","timestamp":1689033600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-GM109086"],"award-info":[{"award-number":["R01-GM109086"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-DC04290"],"award-info":[{"award-number":["R01-DC04290"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Theories of consciousness suggest that brain mechanisms underlying transitions into and out of unconsciousness are conserved no matter the context or precipitating conditions. We compared signatures of these mechanisms using intracranial electroencephalography in neurosurgical patients during propofol anesthesia and overnight sleep and found strikingly similar reorganization of human cortical networks. We computed the \u201ceffective dimensionality\u201d of the normalized resting state functional connectivity matrix to quantify network complexity. Effective dimensionality decreased during stages of reduced consciousness (anesthesia unresponsiveness, N2 and N3 sleep). These changes were not region-specific, suggesting global network reorganization. When connectivity data were embedded into a low-dimensional space in which proximity represents functional similarity, we observed greater distances between brain regions during stages of reduced consciousness, and individual recording sites became closer to their nearest neighbors. These changes corresponded to decreased differentiation and functional integration and correlated with decreases in effective dimensionality. This network reorganization constitutes a neural signature of states of reduced consciousness that is common to anesthesia and sleep. These results establish a framework for understanding the neural correlates of consciousness and for practical evaluation of loss and recovery of consciousness.<\/jats:p>","DOI":"10.1093\/cercor\/bhad249","type":"journal-article","created":{"date-parts":[[2023,6,22]],"date-time":"2023-06-22T18:40:25Z","timestamp":1687459225000},"page":"9850-9866","source":"Crossref","is-referenced-by-count":14,"title":["Analogous cortical reorganization accompanies entry into states of reduced consciousness during anesthesia and sleep"],"prefix":"10.1093","volume":"33","author":[{"given":"Bryan M","family":"Krause","sequence":"first","affiliation":[{"name":"University of Wisconsin Department of Anesthesiology, , Madison, WI , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Declan I","family":"Campbell","sequence":"additional","affiliation":[{"name":"University of Wisconsin Department of Anesthesiology, , Madison, WI , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher K","family":"Kovach","sequence":"additional","affiliation":[{"name":"The University of Iowa Department of Neurosurgery, , Iowa City, IA 52242 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmi N","family":"Mueller","sequence":"additional","affiliation":[{"name":"The University of Iowa Department of Neurosurgery, , Iowa City, IA 52242 , United States"},{"name":"The University of Iowa Department of Anesthesia, , Iowa City, IA 52242 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroto","family":"Kawasaki","sequence":"additional","affiliation":[{"name":"The University of Iowa Department of Neurosurgery, , Iowa City, IA 52242 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirill V","family":"Nourski","sequence":"additional","affiliation":[{"name":"The University of Iowa Department of Neurosurgery, , Iowa 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